Protein Alignment Marcal1 and Smarcal1

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001101692.1
• Gene: Smarcal1 / 316477
• RGDID: 1306134
• Length: 910
• Species: Rattus norvegicus
• Alignment Length: 773
• Identity: 264/773 - (34%)
• Similarity: 396/773 - (51%)
• Gaps: 109/773 - (14%)

  Fly    19 KLQAKKSQLLASAPATNGKS---TTSATGATQHANNG---KSNPNQPQAKSPLNFYRSPTGEQKK 77
            ||:||     |..|:|:|:|   |..|.|......:|   |:....||..|.|......||::.:
  Rat   155 KLEAK-----AGRPSTSGQSISDTFYALGEKTPKTDGRPAKALQTSPQKASCLRGMCLRTGDRFR 214

  Fly    78 IN-----------RSGPT--------PGDNKSSSFLNALKAIKQTSNRELSRGAAHPYQRPNG-G 122
            :.           :|.|:        ..|...|.:...:||:::     ||..:..|.:..:| |
  Rat   215 VKIGYNKELIEVFKSLPSRRYDSFTKTWDFSMSDYRALMKAVER-----LSTVSLQPLEEVDGTG 274

  Fly   123 NERNKPTL-SLSSDKEKPVAVLLGNSITCNLYLISTHRFAAQTSGYHEQLVTVFKNMPTKCYDGQ 186
            .:.:.|:. ||:             .:|....|||..||.... ||.|.::.:||.|.::.||.:
  Rat   275 GQTSLPSAPSLT-------------FVTGRCMLISRARFEVDI-GYSEVVIALFKQMESRNYDPK 325

  Fly   187 TRIWSFDLSDYQSLKTHAADLKPYVHMNGIPKKV-LDLCGQ--------PPVVPERSVLASIEPK 242
            ||.|:|.|.::..|...:.:|| .|.::.:||.: |....|        ...|||.. |:.::.|
  Rat   326 TRKWNFLLEEHNKLIARSRELK-QVQLDPLPKTLTLAFASQLEKTSLQSKADVPEAD-LSGVDAK 388

  Fly   243 LADQLMPFQQDGVCFAIAQKGRIMICDEMGLGKTYQALAVADYFKDDWPLLVCTTASTRDSWAKH 307
            |...|||||::||.|||:::||:::.|:||||||.||:.:|.:::.:|||||...:|.|.:|.:.
  Rat   389 LVSNLMPFQREGVSFAISKRGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQA 453

  Fly   308 IMDLLPKVPIHYVQVLNNNQLYVGEAKVLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAK 372
            .:..||.:....:.|:...:..:....|.|.|::::.:.| |.::..|..:|.||||.|||.|..
  Rat   454 FLRWLPSLSPEDINVVVTGKGRLTAGLVNIVSFDLLSKLE-KQLKTPFKVVIIDESHFLKNIKTA 517

  Fly   373 CTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMIDGKFM-NFMEFTTRYCDGKQSTFGWDAN 436
            ....|..:...||||:|||||||:|||.||:||:..:...|. .|..|..||||.|:..:|||.:
  Rat   518 RCRAAVPILKVAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRLPWGWDYS 582

  Fly   437 GQSNLEELKVILHLKYMLRRTKVEVLPQLAEKNRETVVLDPALVWTNAETKETLDAFNKELKTAK 501
            |.|||.|||::|....||||.|.:||.||..|.|:.||::|..:.|.|  |..|||..||:...|
  Rat   583 GSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQRKMVVVNPGRISTRA--KAALDAAAKEMTKDK 645

  Fly   502 GRATE-EILLRFYARTAEVKTRAVCAYLKTLVKE-QKKFIIFAHHRVMMDAISDFLSGLKVHYIR 564
            .:..: |.||.|:.||||.|...|..|:..|::. ::||::||||:|::|||:..|....|.:||
  Rat   646 TKQQQKEALLVFFNRTAEAKIPCVIEYILDLLESGREKFLVFAHHKVLLDAIAKELERKNVQHIR 710

  Fly   565 IDGQTRSDHRSDSVDTFQKKSSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAH 629
            |||.|.|..|.|....||......||:||:.|.|.|:|.::|:::|||||.|||..|.|||.|.|
  Rat   711 IDGSTPSADREDLCQQFQLSKGHTVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVH 775

  Fly   630 RIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAENLQKATHTAAPTSSHKIEEYFSP 694
            |||||..|...||:|..||||.:|.:::.|.:||.:.|:...|..:.|...         :|...
  Rat   776 RIGQTNSVGIHYLVAKGTADDYLWPLIQEKIKVLGEAGLSETNFSEMTEAT---------DYLYK 831

  Fly   695 STSTSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIAAFFNDDDDEAFLE 752
                  :|::.:|...|.                          .:|.:|.:|..|||
  Rat   832 ------DPKQKTIYSLFQ--------------------------QSFEDDGNDMEFLE 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	18/55 (33%)
		HepA	<233..666	CDD:440319	187/435 (43%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	88/209 (42%)
Smarcal1	NP_001101692.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..170		8/19 (42%)
		Mediates interaction with RPA2. /evidence=ECO:0000250	2..30
		Mediates interaction with RPA2. /evidence=ECO:0000250|UniProtKB:Q9NZC9	5..30
		HARP	213..267	CDD:462166	8/58 (14%)
		HepA	<323..807	CDD:440319	202/488 (41%)
		DEXHc_HARP_SMARCAL1	393..602	CDD:350768	88/209 (42%)
		DESH box	506..509		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NZC9	601..618		9/16 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..890