Protein Alignment Marcal1 and Chd7

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001101376.2
• Gene: Chd7 / 312974
• RGDID: 1311921
• Length: 2985
• Species: Rattus norvegicus
• Alignment Length: 889
• Identity: 199/889 - (22%)
• Similarity: 319/889 - (35%)
• Gaps: 239/889 - (26%)

  Fly     5 SSSEIAEKKRIALAK-------LQAKKSQLLASAPAT-------NGKSTTSATGATQHANNGKSN 55
            |..|..::||..:.|       .:.||......||.|       ..|:.|....:::.::|.|.:
  Rat   629 SQEETKKRKRPKVKKDPKELKEPREKKEPKTPKAPKTPKEPKERKAKTVTPKPKSSKKSSNKKPD 693

  Fly    56 PNQPQAKSPLNFYRSPTGEQKKINRSGP---------TPGDNKSSSFLNALKAIKQT-------S 104
            ......|..:|..::...|...::::.|         .||..|..| ...:|..:.|       |
  Rat   694 SEASALKKKVNKGKTEGSENSDLDKTPPPSPGPEEDEDPGVQKRRS-SRQVKRKRYTEDLEFKIS 757

  Fly   105 NRELSRGAAHPYQRPNGGNERNKPTLSLSSDKEKPVAVLL------------GNSITCNLYLIST 157
            :.|.....|.....|:..::..:..   |.|.|.||...:            |..:....:.:..
  Rat   758 DEEADDADAAGRDSPSNTSQSEQQE---SVDAEGPVVEKIMSSRLVKKQKESGEEVEVEEFYVKY 819

  Fly   158 HRFAAQTSGYHEQLVTV------------FKNMPTKCYDGQTRIWSFDLSDYQSLKTHAADL--K 208
            ..|    |..|.|..:|            .|...:|  .||::..| ::.|         ||  .
  Rat   820 KNF----SYLHCQWASVEDLEKDKRIQQKIKRFKSK--QGQSKFLS-EIED---------DLFNP 868

  Fly   209 PYVHMNGIPKKVLDLC------GQPPV--------------------------VPERSVLASIEP 241
            .||.::    :::|..      |:|..                          :.|...|.|.||
  Rat   869 DYVEVD----RIMDFARSTDDRGEPVTHYLVKWCSLPYEDSTWELRQDLDQAKIEEFEKLMSREP 929

  Fly   242 ----------------------KLADQLMPFQQDGV---CFAIAQKGRIMICDEMGLGKTYQALA 281
                                  |..::|..:|.:||   .|........::.||||||||.|::.
  Rat   930 ETERVERPPADDWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSIT 994

  Fly   282 --VADYFKD-DWPLLVCTTASTRDSWAKHIMDL--LPKVPIHYVQVLNNN-QLY----------- 329
              ...|.|. ..|.||....||..:|.:.....  |..|..|..|..... |||
  Rat   995 FLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRV 1059

  Fly   330 -VGEAK--VLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLS 391
             .|..|  .:||::.|:.....:|....:..::.||:|.|||...|.....|.:..:.|  |||:
  Rat  1060 IKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHK--VLLT 1122

  Fly   392 GTPALSRPLELFTQLQMID-GKFMNFMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHLKYMLR 455
            |||..:...|||:.|..:: .:|.:...|        ...|| |...:..:::|:.||. ..|||
  Rat  1123 GTPLQNTVEELFSLLHFLEPSRFPSETTF--------MQEFG-DLKTEEQVQKLQAILK-PMMLR 1177

  Fly   456 RTKVEVLPQLAEKNRETVVLDPALVWTNAETKETLDAFNKE---LKTAKGRATEEILLRFYARTA 517
            |.|.:|...||.| .||::   .:..||.:.|.......|.   |....|:|....||     ..
  Rat  1178 RLKEDVEKNLAPK-EETII---EVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLL-----NT 1233

  Fly   518 EVKTRAVCAY---------------------------LKTLVKEQKKFIIF---------AHHRV 546
            .::.|..|.:                           |:.:::...|.::.         ..|||
  Rat  1234 MMELRKCCNHPYLINGAEEKILEEFKDAHNADSPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRV 1298

  Fly   547 M--------MDAISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCK-VALLSLKACNSGIT 602
            :        :|.:.|:|...:..|.||||:.|.:.|..::|.|.|..|.: |.||..:|...||.
  Rat  1299 LIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGIN 1363

  Fly   603 LTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVG 667
            ||||:..:..:.||||....||::|.|||||:|.|....||..|:.:..:::      :...|:|
  Rat  1364 LTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFD------KASLKLG 1422

  Fly   668 IFAENLQ------KATHTAAPTSSHKIEEYFSPSTSTSLEPERN 705
            :....||      .||:.....|..:||:........:|..|.:
  Rat  1423 LDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEED 1466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	15/69 (22%)
		HepA	<233..666	CDD:440319	135/526 (26%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	64/232 (28%)
Chd7	NP_001101376.2	Med15	<2..>318	CDD:312941
		Atrophin-1	194..>567	CDD:460830
		CD1_tandem_CHD5-9_like	785..849	CDD:349315	11/67 (16%)
		CD2_tandem_CHD5-9_like	868..925	CDD:349310	6/60 (10%)
		PLN03142	956..>1555	CDD:215601	141/538 (26%)
		BRK	2551..2592	CDD:462196
		BRK	2630..2674	CDD:197800