Protein Alignment Marcal1 and ERCC6

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_000115.1
• Gene: ERCC6 / 2074
• HGNCID: 3438
• Length: 1493
• Species: Homo sapiens
• Alignment Length: 55
• Identity: 13/55 - (23%)
• Similarity: 27/55 - (49%)
• Gaps: 11/55 - (20%)

  Fly    41 DVKEAIRRLPEKLKDERNFRITRALHLSMTKTILPKEQWTKYEEDTKYLEPYLQE 95
            ::::::|.|.|:|.:......|:..||.:: :..|:          |.|.|.||:
Human    41 EMQDSVRNLSEQLPENCETYSTKFYHLGLS-SFTPR----------KLLAPELQK 84

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166
		HepA	<233..666	CDD:440319
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768
ERCC6	NP_000115.1	N-terminal domain, essential for its chromatin remodeling activity. /evidence=ECO:0000269|PubMed:29203878	1..510		13/55 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39
		cc_ERCC-6_N	83..159	CDD:411064	1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..323
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..453
		HepA	391..987	CDD:440319
		DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541	646..649
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1042..1147
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1181..1247
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1318..1384
		CSA-interacting motif (CIM). /evidence=ECO:0000269|PubMed:32355176	1386..1398
		Ubiquitin-binding domain (UBD). /evidence=ECO:0000269|PubMed:20541997	1400..1428
		CSB_WHD	1420..1492	CDD:439329
		Winged-helix domain (WHD). /evidence=ECO:0000305|PubMed:29203878	1429..1493
		Essential for its interaction with RNA polymerase II, transcription-coupled nucleotide excision repair activity, association with chromatin after UV irradiation and for mediating the UV-induced translocation of ERRC8 to the nuclear matrix. /evidence=ECO:0000269|PubMed:26620705	1446..1493