DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marcal1 and csb-1

DIOPT Version :9

Sequence 1:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_510607.2	Gene:	csb-1 / 181674	WormBaseID:	WBGene00000803	Length:	957	Species:	Caenorhabditis elegans

Alignment Length:	663	Identity:	145/663 - (21%)
Similarity:	250/663 - (37%)	Gaps:	162/663 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 DLSDYQSLKTHAADLKPYVHMNGIPKKVLDLCGQPPVVPERSVLAS----IEPKLADQLMPFQQD 253
            |.:|.::.|.....||        |:...:|.....|..|....:|    :...:.::|..|||:
Worm   144 DDNDSKNFKARIDKLK--------PEATSELVDTRMVTSEEYGKSSKPWKVNAGVWNKLHKFQQE 200

  Fly   254 GVCFAIAQK------GRIMICDEMGLGKTYQAL--------AVADYFKD---DWPLLVCTTASTR 301
            ||.:  .||      |.| :.||||||||.|::        ....::|.   |..|:|| ..|..
Worm   201 GVEW--LQKKTDHRSGGI-LADEMGLGKTIQSVVFLRSIQETARTHYKTTGLDTALIVC-HVSII 261

  Fly   302 DSWAKHIMDLLPKVPI---HYVQVLNNNQLYVG--------------EAKVLITSYNMMERHEDK 349
            ..|.|.:....||..:   |........:.|||              :..:::|:|::..:.:..
Worm   262 AQWIKELNQWFPKARVFLLHSHCSTGRQEDYVGSIFRKLQRRRKEYPDGAIILTTYSLFTKLKKP 326

  Fly   350 LMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMI-DGKF 413
            :::..:..:|.||.|.::|...||:...::|....:  .:|:|||..:|..|.:..:..: .|:.
Worm   327 IVKHLWQVVILDEGHYIRNENTKCSIAMRKLMTTQR--FILTGTPFQNRLSEFWKLVDFVHPGRL 389

  Fly   414 MNFMEFTTRYCDGKQSTFGWDANGQSNLE----------ELKVILHL---KYMLRRTK---VEVL 462
            .:...|        ...|....|..:||.          |..|.||:   ..:|||.:   .|||
Worm   390 SDSATF--------HRNFTHIINAGANLNCSPEAAAKAYECLVALHIAVKPLILRRLQEDHKEVL 446

  Fly   463 PQLAEKNRETVVLD----------------------------PALVWTNAETK--------ETLD 491
             ||.||  :.:||.                            .|.|..|..|.        .:|.
Worm   447 -QLPEK--QEIVLSCELSKRQRRLYMEYGNSHQVNEIIERRLKAFVGINHLTNICNHPGIYRSLS 508

  Fly   492 AFNKELKTAKGRATEEILLRFYARTAEVKTRAVCAYLKTLVKEQKKFIIFAHHRVMMDAISDFLS 556
            ..:.:..:.|.....|:..:.:....:..|..|              |:|...|.::..:..||:
Worm   509 PASPKFGSIKDSGKVEMTFKLFDDWFKSPTNRV--------------ILFTQRRTVITMMEYFLA 559

  Fly   557 GLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTL 621
            ...:..:.:.|...:..|...:..|:...|.||.|::.:|...|:.||.|..::..:.||||...
Worm   560 EKGIKCVSLTGADSAAARPKIIKKFEDDVSIKVFLMTTRAGGLGLNLTCANKVIIFDPDWNPQAD 624

  Fly   622 AQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAENLQKATHTAAPTSSH 686
            .||::|.:|:|||..|....|:::.|.:|     ||           |.:.:||....|....:.
Worm   625 NQAKNRIYRMGQTNDVAIYRLVSNGTIED-----LK-----------FFKQVQKENLAARLLHNA 673

  Fly   687 KIEEYFSPSTSTS---LEP---ERNSIKQYFSTIPAKE--PPEQNNNTEMTKVNKAESDIAAFFN 743
            :|:::...:|...   |:|   |.:.|..|.....|:|  ..::.:..|.....|...:..|.|.
Worm   674 EIDQFVPNNTLADLFRLKPKGLEGSEIGVYLDGEIAREGSKKQKRDKVEKKAAKKRMKNKLAGFE 738

  Fly   744 D--------DDDE 748
            |        |||:
Worm   739 DKKLLLSLFDDDK 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	5/21 (24%)
		DEXDc	239..420	CDD:214692	50/215 (23%)
		DEXDc	265..394	CDD:238005	36/156 (23%)
		Helicase_C	518..632	CDD:278689	27/113 (24%)
csb-1	NP_510607.2	SNF2_N	197..503	CDD:278600	74/322 (23%)
		DEXDc	213..369	CDD:238005	37/159 (23%)
		Helicase_C	520..635	CDD:278689	28/128 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D358051at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920