Protein Alignment Marcal1 and smrd-1

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_499301.2
• Gene: smrd-1 / 176462
• WormBaseID: WBGene00010845
• Length: 989
• Species: Caenorhabditis elegans
• Alignment Length: 711
• Identity: 162/711 - (22%)
• Similarity: 273/711 - (38%)
• Gaps: 214/711 - (30%)

  Fly   174 VFKNMPTKCY-------DGQTRIWSFDLSDYQSLKTHAAD-LKPYVHMNGIPKKVLDLCG----- 225
            |..|.|.:.|       .|.||            .|:|.: ...::...||..::||.|.
 Worm   318 VLANRPFEIYGAMVAKMKGVTR------------GTNAIEAYMEFLEKRGILSRILDDCKDHAHT 370

  Fly   226 -------------QPPVVPERSVLASIEPKLADQLMPFQQDGVCFAIAQKGR---IMICDEMGLG 274
                         |.|::.|...|..           :|..||.:.|....:   .::.||||||
 Worm   371 VTKDFERCTEGPLQLPLLKEGCTLHD-----------YQLIGVKWLIMMYNKDLNAILGDEMGLG 424

  Fly   275 KTYQALAVADYFKD---DWPLLVCTTASTRDSWAKHIMDLLPKVPIHYVQVLNNNQLYVG---EA 333
            ||.|.:|...|.|.   ..|.|:...:||.::|........|.     :|:|.    |.|   |.
 Worm   425 KTIQIVAFLSYLKQIGKTGPHLIVVPSSTIENWIGEFHKWCPS-----IQLLT----YYGSQDER 480

  Fly   334 K--------------VLITSYNMM-ERHEDKLMQRKF--GFIIFDESHTLKNSKAKCTTTAKR-- 379
            |              |::|:|||: .:.:||...:.|  .::|:||.|.|||    |.:...|
 Worm   481 KHLRHRVKKQKDHIDVILTTYNMVTSKSDDKKFFKNFSLNYVIYDEGHMLKN----CDSERYRGL 541

  Fly   380 LTDQAKRVVLLSGTPALSRPLELFTQLQMIDGKFMNFMEFTTRYCDG--------KQSTFGWDAN 436
            :..:.|:.:||:|||..:..:||.:.:..:..|..|      :||:.        ||.....|..
 Worm   542 MKVKGKKKILLTGTPLQNNLIELISLMYFVLSKVFN------KYCEDITHLLQHFKQLGPALDTK 600

  Fly   437 G-----QSNLEELKVILHLKYMLRRTKVEVLPQLAEKNRETVVLD---------PALVWTNAETK 487
            .     |..:||.|.||. .|:|||.|.:||..|..|:.:.:.::         ..:|....:::
 Worm   601 NKALYQQDRIEEAKAILQ-PYILRRLKNQVLGSLPSKSEQIIEVEMKKPQKQLYDNIVEALQQSE 664

  Fly   488 ETLDAFNKELKTAKGRATEEILLRFYART---------------------------------AEV 519
            |:.|::...::..  :|....|||....|                                 :::
 Worm   665 ESGDSYGSLMRLR--QAANHPLLRRSEYTDQKLDKIAKMLCLREKAYADKKWQHVSEDLAWLSDI 727

  Fly   520 KTRAVCAYL----KTLVKEQ----------------------KKFIIFAHHRVMMDAISDFLSGL 558
            |...:|...    |.|:.||                      .|.:||:....|:|.:..:|:..
 Worm   728 KIHQLCERFRCTSKFLLNEQLALKSGKCEQLDVMLPEIQKKGDKVLIFSQFTSMLDILEVYLNIR 792

  Fly   559 KVHYIRIDGQTRSDHRSDSVDTFQKKSSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQ 623
            ...|.|:||||....|.:.::.|.......|.|||.:|...||.||:|..|:..::|:||....|
 Worm   793 GYSYKRLDGQTPVLDRQEMINEFNLSKDLFVFLLSTRAGGLGINLTSANHIIIHDIDFNPYNDKQ 857

  Fly   624 AESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAENLQKATHTAAPTSSHKI 688
            ||.|.||:||.|||....|::..|.:                ||:.|...:|.          ::
 Worm   858 AEDRCHRMGQEKPVHVTRLVSKGTVE----------------VGMLALAKKKL----------QL 896

  Fly   689 EEYFSPSTSTSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIAAFFNDDDDEA 749
            |:..:......|  :.:::::    :..:|..||....:::|:  ..|.|:..::|.:|::
 Worm   897 EKQVTDGVKGQL--DEDALRE----LKEEEGGEQCGGRDLSKL--LSSAISGRYDDVEDDS 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	9/49 (18%)
		HepA	<233..666	CDD:440319	131/541 (24%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	68/249 (27%)
smrd-1	NP_499301.2	HepA	<393..902	CDD:440319	136/567 (24%)