DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Marcal1 and smrc-1

DIOPT Version :9

Sequence 1:	NP_608883.1	Gene:	Marcal1 / 33709	FlyBaseID:	FBgn0031655	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_741192.1	Gene:	smrc-1 / 175907	WormBaseID:	WBGene00015806	Length:	690	Species:	Caenorhabditis elegans

Alignment Length:	733	Identity:	242/733 - (33%)
Similarity:	383/733 - (52%)	Gaps:	97/733 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IAEKKRIALAKLQAKKSQLLASAPATNGKSTTSATGATQHANNGKSNPNQPQAKSPLNFYRSPTG 73
            :.:::|.|:||   |:.:.:..|.|...:...:|..||. :.:..:.|..|:...|:.|.::
Worm     3 LTDEQRQAIAK---KREEAIRRAAAYREREMQAAANATA-STSSAAPPAPPKPVIPVMFSQN--- 60

  Fly    74 EQKKINRSGPTPGDN-KSSSFLNALKAIKQTSNRELSRGAAHPYQRPNGGNERNKPTLSLSSDKE 137
             ::......||..:: |.|:..|.:|.:::.....|.                 |||:.:.
Worm    61 -RQNFQPMKPTMNNSTKQSTINNYIKQVQKPEPTSLI-----------------KPTIGVK---- 103

  Fly   138 KPVAVLLGNSITCNLYLISTHRFAAQTSGYHEQLVTVFKNMPTKCYDGQTRIWSFDLSDY---QS 199
              :.:.:|:.|....|            .:|..::.:.|.:|::.||...|.|:...||:   .:
Worm   104 --LKLDIGDRIKIEFY------------PFHSAVIDLIKQVPSRNYDPAKRSWTVASSDHITISN 154

  Fly   200 LKTHAADLKPYVHMNGIPKKVLDLCGQPPVVPERSVLASIEPKLADQLMPFQQDGVCFAIAQKGR 264
            :..:|..:|  |.:..:|:.::.|....|......:...::|.|.::|.|:|::||.||:.:.||
Worm   155 ILKNATAVK--VELEPLPQNIIGLTNFKPKAAPSDLNTVMDPSLIERLFPYQKEGVIFALERDGR 217

  Fly   265 IMICDEMGLGKTYQALAVADYFKDDWPLLVCTTASTRDSWAKHIMDLLPKVPIHYVQVLNNNQLY 329
            |::.|||||||:.|||.:|.|:|.|||||:...||.:.:|.|.:....|  .||.:.:::.:...
Worm   218 ILLADEMGLGKSVQALTIARYYKADWPLLIVCPASVKGAWKKQLNTFFP--IIHRIFIVDKSSDP 280

  Fly   330 VGEA----KVLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLL 390
            :.:.    .|.|.||..|....|.|.:.|:..|||||||.||:.||:.|..|..|:..|..|:||
Worm   281 LPDVCTSNTVAIMSYEQMVLKHDILKKEKYRTIIFDESHMLKDGKARRTKVATDLSKVALHVILL 345

  Fly   391 SGTPALSRPLELFTQLQMIDGK-FMNFMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHLKYML 454
            |||||||||.|||||:::||.| |.||.||..|||||||..|.::|.|.:|.|||..|:..:.|:
Worm   346 SGTPALSRPSELFTQIRLIDHKLFTNFHEFAIRYCDGKQGRFCFEAKGCTNSEELAAIMFKRLMI 410

  Fly   455 RRTKVEVLPQLAEKNRETVVLDPALVWTNAETKETLDAFNKELKTAKG--------RATEEILLR 511
            ||.|.:||..|.||.||.|.:          :..|:||...:|:.|:.        ....|.||.
Worm   411 RRLKADVLKDLPEKRREVVYV----------SGPTIDARMDDLQKARADYEKVNSMERKHESLLE 465

  Fly   512 FYARTAEVKTRAVCAYLKTLVKEQ--------KKFIIFAHHRVMMDAISDFLSGLKVHYIRIDGQ 568
            ||:.|..||..|||.:    :.|.        :|.:|||||::::|.|...::..|:..|||||:
Worm   466 FYSLTGIVKAAAVCEH----ILENYFYPDAPPRKVLIFAHHQIVLDTIQVEVNKRKLGSIRIDGK 526

  Fly   569 TRSDHRSDSVDTFQKKSSCKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQ 633
            |.|..|:...|:||...:.:||:||:.|...|||||||.::||||:.:||..|.|||.||||:||
Worm   527 TPSHRRTALCDSFQTDDNIRVAVLSITAAGVGITLTAASVVVFAEIHFNPGYLVQAEDRAHRVGQ 591

  Fly   634 TKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAENLQKA-------THTAAPTSSHKIEEY 691
            ...|..:||||..||||::|||::.|.:||.:|.:.::..:.|       ...|.|    .|.||
Worm   592 KDSVFVQYLIAKKTADDVMWNMVQQKLDVLGQVSLSSDTFRTADKMHLRFNDAAQP----GIAEY 652

  Fly   692 FSPSTSTSLEPERNSIKQ 709
            ...:..|:::...:.:::
Worm   653 LKKTPDTTIDEWEDPVEE 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..215	CDD:284784	12/57 (21%)
		DEXDc	239..420	CDD:214692	84/185 (45%)
		DEXDc	265..394	CDD:238005	54/132 (41%)
		Helicase_C	518..632	CDD:278689	52/121 (43%)
smrc-1	NP_741192.1	HARP	118..168	CDD:284784	12/51 (24%)
		HepA	<136..629	CDD:223627	204/510 (40%)
		DEXDc	218..349	CDD:238005	54/132 (41%)
		Helicase_C	474..590	CDD:278689	51/119 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165653
Domainoid	1	1.000	179	1.000	Domainoid score	I2112
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8558
Inparanoid	1	1.050	365	1.000	Inparanoid score	I1261
Isobase	1	0.950	-	0	Normalized mean entropy	S4019
OMA	1	1.010	-	-		QHG48755
OrthoDB	1	1.010	-	-		D1082831at2759
OrthoFinder	1	1.000	-	-		FOG0006560
OrthoInspector	1	1.000	-	-		oto20438
orthoMCL	1	0.900	-	-		OOG6_101361
Panther	1	1.100	-	-	LDO	PTHR45766
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4759
SonicParanoid	1	1.000	-	-		X4798
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890