Protein Alignment Marcal1 and chd-7

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_491426.2
• Gene: chd-7 / 172079
• WormBaseID: WBGene00007053
• Length: 2967
• Species: Caenorhabditis elegans
• Alignment Length: 892
• Identity: 195/892 - (21%)
• Similarity: 322/892 - (36%)
• Gaps: 211/892 - (23%)

  Fly     2 STCSSSEIAEKKRIALAKLQAKKSQLLASAPATNGKSTTSATGATQHANNGKSNPNQPQAKSPLN 66
            :|.|..:...:..:.:||.:.||     |...::........|..:....|......|..::.:.
 Worm   899 ATSSKKKSYRRPAVVVAKSRKKK-----SVDDSDDDDFYPQRGRGKKKGGGGKKKADPTDEAGVE 958

  Fly    67 FYRSPTGEQK---KINRSGPTPGDNKSSSFLNAL--KAIKQTSNRELSRGAAHPYQRP------- 119
            ..:|...:.:   ||:...|.|........||..  |..|:....|::.|:....:..
 Worm   959 GAKSDDEDDEFLMKIDTPAPDPNAMVVEKILNMRMGKVEKKVPETEVAEGSEENGEEKSEEKVKK 1023

  Fly   120 -------------NGGNERNKPTLSLSSDKEKPVAVLL----GNSITCNLYLISTHRFAAQTSGY 167
                         ||.:.::|.....:..:|:.|...|    |.|     |:....:.||:....
 Worm  1024 EPKENGENGESVGNGESSKSKTESETNEIEEEEVEQFLIKWKGRS-----YVHCEWKTAAELLEI 1083

  Fly   168 HEQLVTVFKNMPTK---CY------------------------DGQTRIWSFDLSDYQSLKTHAA 205
            .:::....|....|   .|                        |||    .|.|..::||.....
 Worm  1084 DKRVEAKIKRFKVKKMSSYIEDDEDFNSDFVIVDRVVDLITEDDGQ----EFVLIKWKSLGYEEV 1144

  Fly   206 DLKPYVHMNGIPKKVLDLCGQPPVVPERSVLASIEP--------------KLADQLMPFQQDGV- 255
            ..:| :.|  ||...::|..:..|:....:.....|              |..:.|..:|.:||
 Worm  1145 TWEP-IEM--IPADKVELWRERQVIDPAKIREKQRPEPEEWKKMSTSKVWKNGNSLREYQFEGVD 1206

  Fly   256 ----CFAIAQKGRIMICDEMGLGKTYQALAVADYFKD---DWPLLVCTTASTRDSWAK------- 306
                |:..||  ..::.||||||||.|.:.......|   ..|.||....||..:|.:
 Worm  1207 WLLYCYYNAQ--NCILADEMGLGKTVQTITFLSRIYDYGIHGPFLVVVPLSTIQNWVREFETWTD 1269

  Fly   307 ----------HIMDLLPKVPIHYVQ----VLNNNQLYVGEAKVLITSYNMMERHEDKLMQRKFGF 357
                      :..::|.:..:.|.:    ..|..:.:| :...|||::..:....:.|.:..:..
 Worm  1270 MNAIVYHGSAYAREVLQQYEVFYDKRHCGAKNWKKNFV-KIDALITTFETVVSDVEFLKKIPWRV 1333

  Fly   358 IIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMI-DGKFMNFMEFTT 421
            .:.||:|.|||...|..... .|..:.:..|||:|||..:...|||:.|..: ..:|.|...|..
 Worm  1334 CVIDEAHRLKNRNCKLLVNG-LLAFRMEHRVLLTGTPLQNNIDELFSLLNFLHPQQFDNSATFLE 1397

  Fly   422 RYCDGKQSTFGWDANGQSNLEELKVILHLKYMLRRTKVEVLPQLAEKNRETV------------- 473
            ::  |...|       ...:::|:.||. ..||||.|.:|...|..| .||:
 Worm  1398 QF--GSCQT-------DDQVQKLQEILK-PMMLRRLKEDVEKSLGPK-EETIIEVQLSDMQKKFY 1451

  Fly   474 --VLD------------PALVWTNAETKETL----------DAFNKELKTAKGRATEEILLRFYA 514
              :|:            |:|:....|.::..          :|...:.:.|.....||.|.....
 Worm  1452 RAILERNFSHLCKGTSAPSLMNVMMELRKCCNHPFLINGAEEAIMNDFRLAHPDWDEETLAHKAL 1516

  Fly   515 RTAEVKTRAVCAYLKTLVKEQKKFIIFAHHRVMMDAISDFLSGLKVHYIRIDGQTRSDHRSDSVD 579
            ..|..|...:...|..|.|:..|.:||:....::|.:.:||..:...:.||||..|.|.|..::|
 Worm  1517 IQASGKVVLIEKLLPKLRKDGHKVLIFSQMVKVLDLLEEFLISMSYPFERIDGNVRGDLRQAAID 1581

  Fly   580 TFQKKSSCK-VALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLI 643
            .|.|::|.: |.||..:|...||.||||:.::..:.||||....||::|.|||||.|.|....||
 Worm  1582 RFSKENSDRFVFLLCTRAGGLGINLTAADTVIIFDSDWNPQNDLQAQARCHRIGQKKLVKVYRLI 1646

  Fly   644 AHNTADDIIWNMLKNKQEVLSKVGIFAENLQKATHTAA---PTSSHKIEEYFSPSTSTSLEPERN 705
            ..||.:..:::      :...|:|:....||..|...|   ..|...:||........|:..|.|
 Worm  1647 TSNTYEREMFD------KASLKLGLDKAVLQSTTALKAEGTALSKKDVEELLKKGAYGSIMDEEN 1705

  Fly   706 SIKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIAAFFNDDDDEAFLE 752
                                 |.:|           ||::|.|..|:
 Worm  1706 ---------------------ESSK-----------FNEEDIETILQ 1720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	14/82 (17%)
		HepA	<233..666	CDD:440319	128/514 (25%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	59/238 (25%)
chd-7	NP_491426.2	Atrophin-1	<387..>666	CDD:460830
		PRK12323	<582..732	CDD:481241
		CD1_tandem_CHD5-9_like	979..1095	CDD:349315	19/120 (16%)
		CD2_tandem	1112..1162	CDD:349306	12/56 (21%)
		PLN03142	1197..>1803	CDD:215601	145/577 (25%)
		SANT	2073..2133	CDD:197842
		BRK	2672..2716	CDD:197800