Protein Alignment Marcal1 and Hel89B

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: XP_321235.5
• Gene: Hel89B / 1281292
• VectorBaseID: AGAMI1_004308
• Length: 2067
• Species: Anopheles gambiae
• Alignment Length: 737
• Identity: 171/737 - (23%)
• Similarity: 286/737 - (38%)
• Gaps: 169/737 - (22%)

  Fly   128 PTLSLSSDKEKPVAVLLGNSITCNLYLISTHRFAAQTSGYHEQLVTVFKNMPTKCYDG------- 185
            |.|...||.::.|.            |:|||.||           |:.:.||   .||
Mosquito  1380 PLLGRMSDPDQSVR------------LVSTHCFA-----------TLIQLMP---LDGLGTSGDG 1418

  Fly   186 --QTRIWSFDLSDYQSLKTHAADLKPYVHMNGIPKKVLDLCGQPPVVPERSVLASIEPKLADQLM 248
              ..|..|.||.. :.:|               .::.|:....|..:|:    ..:..|:..:|.
Mosquito  1419 GASGRHLSDDLRQ-RKMK---------------DRRFLEYLFSPKTIPD----VELPVKINAELR 1463

  Fly   249 PFQQDGV---CFAIAQKGRIMICDEMGLGKTYQALAV--ADYFK-------DDWPLLVCTTASTR 301
            .:||.||   .|....|...::||:||||||.||:.:  ||:.:       ...|.:|....:..
Mosquito  1464 SYQQSGVNWLWFLNRYKLHGILCDDMGLGKTLQAICILAADHHQRSLDRGCAQLPSIVICPPTLT 1528

  Fly   302 DSWAKHIMDLLPK---VPIHYVQVLNNNQLY---VGEAKVLITSYNMMERHEDKLMQRKFGFIIF 360
            ..|...:...||.   .|:|||.:..|.:..   :|...:::.||:::.:..:......:.:.|.
Mosquito  1529 GHWVYEVEKFLPSRFLRPLHYVGLPGNREQLRQKLGTYNLIVASYDIVRKDIEFFSSVNWNYCIL 1593

  Fly   361 DESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMIDGKFMNF-MEFTTRYC 424
            ||.|.:||.:.|.:...|:|.  |...::|||||..:..|||::....:...|:.. .:|:||:.
Mosquito  1594 DEGHIIKNGRTKSSKAIKQLV--ANHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEKQFSTRFS 1656

  Fly   425 -------DGKQSTFGWDANGQSNLEELKVILH---LKYMLRRTKVEVLPQLAEKNRETVV--LDP 477
                   |.|.|....:| |...:|    .||   |.::|||.|.:||..|..|..:.::  |.|
Mosquito  1657 RPILASRDPKSSPKEQEA-GALAME----ALHRQVLPFLLRRVKEDVLTDLPPKITQDLLCELSP 1716

  Fly   478 ----------ALVWTNAETKETLDAFNKELKTAKGRATE-------------------------- 506
                      .:...:::.:|.|:..:.::.....:.|.
Mosquito  1717 LQERLYEDFSRMHLHSSDIRECLENIDGQMAGPANKKTHVFQALRYLQNVCNHPKLVLSPSHPEY 1781

  Fly   507 EILLRFYARTA----EVKTRAVCAYLKTLVKE------------QKKFIIFAHHRVMMDAISDFL 555
            ::::..:.|..    :::..|....||.|:.:            |.:.:||...:.|:|.:.:.|
Mosquito  1782 QMIVGEFTRNGSSMDDIEHSAKLPVLKQLLLDCGIGTNEDVSVNQHRALIFCQLKAMLDIVENDL 1846

  Fly   556 SGLKVH-----YIRIDGQTRSDHRSDSVDTFQKKSSCKVALLSLKACNSGITLTAAEIIVFAELD 615
              ||.|     |:|:||......|...|..|....|..|.||:.:....|:.||.|:.::|.|.|
Mosquito  1847 --LKKHLPAVSYLRLDGSVPPSTRHHIVTKFNGDPSIDVLLLTTQVGGLGLNLTGADTVIFVEHD 1909

  Fly   616 WNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAENLQKAT--- 677
            |||....||..|||||||.|.|....||...:.::.|..:.|.|....:.| :..||....|
Mosquito  1910 WNPMKDLQAMDRAHRIGQKKVVNVYRLITRKSLEEKIMGLQKFKLLTANTV-VSDENASMDTMGT 1973

  Fly   678 ------HTAAPTSSHKIEEYFSPSTSTSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAES 736
                  .|.|..|. |.:.......:|::...|.|::...:...|....|.|.:.....:.....
Mosquito  1974 DQLLDLFTLADDSG-KQQRAGGGGATTAVSDRRGSLRSAAAASNAAAQLEANGSNGGAAIKTVLE 2037

  Fly   737 DIAAFFNDD------DDEAFLE 752
            ::...::|.      |...|||
Mosquito  2038 NLPELWDDSQYHEEYDLSQFLE 2059

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	12/64 (19%)
		HepA	<233..666	CDD:440319	128/520 (25%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	64/237 (27%)
Hel89B	XP_321235.5	HEAT repeat	5..30	CDD:293787
		HEAT repeat	42..70	CDD:293787
		DUF3535	715..1242	CDD:463447
		HepA	<1453..1962	CDD:440319	129/518 (25%)