DRSC/TRiP Functional Genomics Resources

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Protein Alignment Marcal1 and CHD4

DIOPT Version :10

Sequence 1:NP_608883.1 Gene:Marcal1 / 33709 FlyBaseID:FBgn0031655 Length:755 Species:Drosophila melanogaster
Sequence 2:NP_001264.2 Gene:CHD4 / 1108 HGNCID:1919 Length:1912 Species:Homo sapiens


Alignment Length:746 Identity:169/746 - (22%)
Similarity:291/746 - (39%) Gaps:159/746 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 YQRPN----------GGNE------RNKPTLSLSSDKE------KPVAVLLGNSITCNLYLISTH 158
            |||.|          ||:|      :||.......::.      ||..:::             |
Human   574 YQRKNDMDEPPSGDFGGDEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMI-------------H 625

  Fly   159 RF---AAQTSGYHEQLVTVFKNMPTKCYDGQTRIW---SFDLSDY----QSLKTH-----AADLK 208
            |.   :....|:...|:. ::::|   ||..:  |   ..::.||    ||...|     ..:.:
Human   626 RILNHSVDKKGHVHYLIK-WRDLP---YDQAS--WESEDVEIQDYDLFKQSYWNHRELMRGEEGR 684

  Fly   209 PYVHMNGIPKKVLDLCGQPPVVP--ERSVLASIEPKLAD----QLMPFQQDG---VCFAIAQKGR 264
            |...:..:..:.|:   :||..|  :.:|....:|:..|    .|.|:|.:|   :.|:.||...
Human   685 PGKKLKKVKLRKLE---RPPETPTVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTD 746

  Fly   265 IMICDEMGLGKTYQ-ALAVADYFKD---DWPLLVCTTASTRDSWAKHIMDLLPKV-PIHYV---- 320
            .::.||||||||.| |:.:...:|:   ..|.||....||..:|.:......|.: .:.||    
Human   747 TILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKD 811

  Fly   321 --QVLNNNQLYV------GEAK-------------VLITSYNMMERHEDKLMQRKFGFIIFDESH 364
              .::..|:...      |..|             ||:|||.::......|....:..:|.||:|
Human   812 SRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAH 876

  Fly   365 TLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALSRPLELFTQLQMI-DGKFMNFMEFTTRYCDGKQ 428
            .|||:::|........:.|.|  :||:|||..:...|||..|..: ..:|.|...|...:.|..:
Human   877 RLKNNQSKFFRVLNGYSLQHK--LLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAK 939

  Fly   429 STFGWDANGQSNLEELKVILHLKYMLRRTKVEVLPQLAEKNRETVV---LDPALVWTNAETKETL 490
                     :..:::|..:|. .:||||.|.:|...:..|. |.:|   |.|    ...:..:.:
Human   940 ---------EDQIKKLHDMLG-PHMLRRLKADVFKNMPSKT-ELIVRVELSP----MQKKYYKYI 989

  Fly   491 DAFNKELKTAKGRATEEILLR----------------------------FYARTAEVKTRAVCAY 527
            ...|.|...|:|...:..||.                            .|..:|.::.......
Human   990 LTRNFEALNARGGGNQVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLL 1054

  Fly   528 LKTLVKEQK----KFIIFAHHRVMMDAISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCK 588
            |:.::|..|    :.:||:....|:|.:.|||......|.||||....:.|.:::|.|....:.:
Human  1055 LQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNMRQEAIDRFNAPGAQQ 1119

  Fly   589 VA-LLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDII 652
            .. |||.:|...||.|..|:.::..:.||||....||.||||||||.|.|:....:...:.::.|
Human  1120 FCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERI 1184

  Fly   653 WNMLKNKQ---EVLSKVGIFAENLQKATHTAAPTSSHKIEEYFSPSTS----TSLEPERNSIKQY 710
            ..:.|.|.   .::.:.|:.::....:............||.|....:    .:.|.|.:|:..|
Human  1185 TQVAKKKMMLTHLVVRPGLGSKTGSMSKQELDDILKFGTEELFKDEATDGGGDNKEGEDSSVIHY 1249

  Fly   711 FSTIPAKEPPEQNNNTEMTKVNKAESDIAAF 741
            ......:......:.||.|::......:::|
Human  1250 DDKAIERLLDRNQDETEDTELQGMNEYLSSF 1280

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Marcal1NP_608883.1 HARP 160..216 CDD:462166 12/70 (17%)
HepA <233..666 CDD:440319 128/509 (25%)
DEXHc_HARP_SMARCAL1 247..456 CDD:350768 63/242 (26%)
CHD4NP_001264.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..157
CHDNT 164..217 CDD:462357
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 243..360
KIKL. /evidence=ECO:0000269|PubMed:29567837 295..298
PHD1_CHD_II 372..414 CDD:277006
PHD2_CHD_II 451..493 CDD:277007
CD1_tandem_CHD3-4_like 498..576 CDD:349314 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..537
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 578..603 6/24 (25%)
CD2_tandem_CHD3-4_like 619..673 CDD:349309 13/72 (18%)
PLN03142 724..>1281 CDD:215601 137/574 (24%)
DEXHc_CHD4 726..957 CDD:350814 63/242 (26%)
DEAH box 873..876 2/2 (100%)
DUF1087 1302..1345 CDD:461922
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1344..1401
CHDII_SANT-like 1381..1521 CDD:461920
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1525..1562
PRK12323 <1532..>1658 CDD:481241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1570..1589
Required for interaction with PCNT. /evidence=ECO:0000269|PubMed:17626165 1577..1912
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1594..1644
CHDCT2 1726..1871 CDD:462358
Blue background indicates that the domain is not in the aligned region.

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