DRSC/TRiP Functional Genomics Resources

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Protein Alignment Marcal1 and CHD2

DIOPT Version :10

Sequence 1:NP_608883.1 Gene:Marcal1 / 33709 FlyBaseID:FBgn0031655 Length:755 Species:Drosophila melanogaster
Sequence 2:NP_001262.3 Gene:CHD2 / 1106 HGNCID:1917 Length:1828 Species:Homo sapiens


Alignment Length:589 Identity:138/589 - (23%)
Similarity:239/589 - (40%) Gaps:116/589 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 QLMPFQQDG---VCFAIAQKGRIMICDEMGLGKTYQALAVADYFKDD----WPLLVCTTASTRDS 303
            :|..:|.:|   :..:..:...:::.||||||||.|.::...|....    .|.|:....||..|
Human   483 ELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVVPLSTLTS 547

  Fly   304 WAKHIMDLLPKVPIHYVQVLNNNQLYVGEA---------------------KVLITSYNMMERHE 347
            |.:......|::         |..:|:|:.                     ..|||:|.::.:.:
Human   548 WQREFEIWAPEI---------NVVVYIGDLMSRNTIREYEWIHSQTKRLKFNALITTYEILLKDK 603

  Fly   348 DKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTD-QAKRVVLLSGTPALSRPLELFTQLQMI-D 410
            ..|....:.|:..||:|.|||..   :...|.|.| ::...:|::|||..:...||::.|..| .
Human   604 TVLGSINWAFLGVDEAHRLKNDD---SLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMP 665

  Fly   411 GKFMNFMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHLKYMLRRTKVEVLPQLAEKNRETVVL 475
            .||..:.:|...:..|::       ||..:|.  ||:  ..::|||.|.:|...|..|..:.:.:
Human   666 EKFEFWEDFEEDHGKGRE-------NGYQSLH--KVL--EPFLLRRVKKDVEKSLPAKVEQILRV 719

  Fly   476 DPALV------W------------TNAETKETLDAFNKELKTA-------------KGRATEEIL 509
            :.:.:      |            |...|...|:.. .|||..             :....:|||
Human   720 EMSALQKQYYKWILTRNYKALAKGTRGSTSGFLNIV-MELKKCCNHCYLIKPPEENERENGQEIL 783

  Fly   510 LRFYARTAEVKTRAVCAYLKTLVKEQ-KKFIIFAHHRVMMDAISDFLSGLKVHYIRIDGQTRSDH 573
            |.....:.::   .:...|.|.::|: .:.:||:....|:|.::::|:.....:.|:||..:.:.
Human   784 LSLIRSSGKL---ILLDKLLTRLRERGNRVLIFSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEI 845

  Fly   574 RSDSVDTFQKKSS---CKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTK 635
            |..::|.|....|   |  .|||.:|...||.|.:|:.:|..:.||||....||::|||||||.|
Human   846 RKQALDHFNADGSEDFC--FLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKK 908

  Fly   636 PVICRYLIAHNTADDIIWNMLKNKQEVLSKVGI---------FAENLQKATHTAAPTSSHKI--- 688
            .|....|:...|.::.|....|.|. ||..:.|         ..|| ......:.|.:..::   
Human   909 QVNIYRLVTKGTVEEEIIERAKKKM-VLDHLVIQRMDTTGRTILEN-NSGRSNSNPFNKEELTAI 971

  Fly   689 -----EEYFSPSTSTSLEPERNSIKQYFSTIPAKEPPEQNNNTEMTKVNKAESDIAAFFNDDDDE 748
                 |:.|........||:...|.:   .:...|..|...:|..|....::..:|.|...:|:|
Human   972 LKFGAEDLFKELEGEESEPQEMDIDE---ILRLAETRENEVSTSATDELLSQFKVANFATMEDEE 1033

  Fly   749 AFLE 752
            ...|
Human  1034 ELEE 1037

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Marcal1NP_608883.1 HARP 160..216 CDD:462166
HepA <233..666 CDD:440319 120/484 (25%)
DEXHc_HARP_SMARCAL1 247..456 CDD:350768 56/238 (24%)
CHD2NP_001262.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..243
CD1_tandem_CHD1-2_like 259..343 CDD:349313
CD2_tandem_CHD1-2_like 376..447 CDD:349308
DEXHc_CHD2 464..700 CDD:350812 56/239 (23%)
PLN03142 468..>1021 CDD:215601 133/571 (23%)
DEAH box 617..620 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1030..1124 3/8 (38%)
CDH1_2_SANT_HL1 1130..1218 CDD:465731
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1331..1462
CHD1 helical C-terminal domain (CHCT). /evidence=ECO:0000250|UniProtKB:O14646 1464..1566
DUF4208 1471..1553 CDD:464035
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1556..1638
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1680..1828
Blue background indicates that the domain is not in the aligned region.

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