Protein Alignment Marcal1 and CHD1

DIOPT Version :10

• Sequence 1: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_001351042.1
• Gene: CHD1 / 1105
• HGNCID: 1915
• Length: 1798
• Species: Homo sapiens
• Alignment Length: 973
• Identity: 211/973 - (21%)
• Similarity: 347/973 - (35%)
• Gaps: 297/973 - (30%)

  Fly     5 SSSEIAEKKRIALAKLQAKKSQLLAS-APATNG----------KSTTSATGATQHANNGKSNPNQ 58
            ||||:..||.      :.:..|:..| :|:.:|          ||:...|.:.....| |....:
Human   135 SSSEVKRKKH------KDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETESDYEPKN-KVKSRK 192

  Fly    59 PQAKSPLNFYRSPTGEQKKINRSGPTPGD------NKSSSFLNALKAIKQTSNRELS-------- 109
            ||.:|.....:...|::|:...|.....|      :|.||...|...:....:.|:.
Human   193 PQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNVSYKEDEEMKTDSDDLLE 257

  Fly   110 ---------------------------RGAAHPYQR---------PNGGNERNKPTLSLSSDKEK 138
                                       :||......         ||.|.|:||....:.
Human   258 VCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEIQ----- 317

  Fly   139 PVAVLLGNSITCNLYLIS------THRFAAQTSGYHEQLVTVFKNMPT-KCYDGQTRIWSFDLS- 195
                          |||.      .|..........:|.|...|.:.. |..|.:|:.|..:.|
Human   318 --------------YLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASP 368

  Fly   196 ---DYQSLKTHAAD--LKPY-------VHMN---------------GIP------------KKVL 221
               :|.:.:....|  .|.|       .|.|               |:|            .|..
Human   369 EDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSECSWEDGALISKKF 433

  Fly   222 DLC-------GQPPVVP----------ERSVLASIEPKLAD-----QLMPFQQDGV-------CF 257
            ..|       .|....|          .|.|....:|....     :|..:|.:|:       |
Human   434 QACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWC- 497

  Fly   258 AIAQKGR-IMICDEMGLGKTYQALAVADYFKDD----WPLLVCTTASTRDSWAKHIMDLLPKVPI 317
                ||. .::.||||||||.|.::..:|...:    .|.|:....||..||.:.|.....::
Human   498 ----KGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQM-- 556

  Fly   318 HYVQVLNNNQLYVGEAKVLITSYNMMERHE------------------DKLMQRK-------FGF 357
                   |..:|:|:    |.|.||:..||                  :.|::.|       :.|
Human   557 -------NAVVYLGD----INSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDKAFLGGLNWAF 610

  Fly   358 IIFDESHTLKNSKAKCTTTAKRLTD-QAKRVVLLSGTPALSRPLELFTQLQMI-DGKFMNFMEFT 420
            |..||:|.|||..   :...|.|.| ::...:|::|||..:...||::.|..| ..||.::.:|.
Human   611 IGVDEAHRLKNDD---SLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFE 672

  Fly   421 TRYCDGKQSTFGWDANGQSNLEELKVILHLKYMLRRTKVEVLPQLAEKNRETVVLDPALV----- 480
            ..:  ||...:|: |:....||        .::|||.|.:|...|..|..:.:.::.:.:
Human   673 EEH--GKGREYGY-ASLHKELE--------PFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYY 726

  Fly   481 -WTNAETKETLDAFNK-----------ELKTA-------KGRATEEILLRFYARTAEVKTRAVCA 526
             |......:.|...:|           |||..       |.....|...:..|....:::.....
Human   727 KWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLIRSSGKLI 791

  Fly   527 YL-KTLVKEQK---KFIIFAHHRVMMDAISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSS- 586
            .| |.|::.::   :.:||:....|:|.::::|...:..:.|:||..:.:.|..::|.|..:.|
Human   792 LLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRKQALDHFNAEGSE 856

  Fly   587 --CKVALLSLKACNSGITLTAAEIIVFAELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTAD 649
              |  .|||.:|...||.|.:|:.:|..:.||||....||::|||||||.|.|....|:...:.:
Human   857 DFC--FLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGSVE 919

  Fly   650 DIIWNMLKNKQEVLSKVGIFAENLQKATHTAAPTSSHKIEEYFSPSTSTSLEPER-NSIKQYFST 713
            :.|....|.|. ||..:.|  :.:.....|...|.|       :||:||....|. ::|.::.:.
Human   920 EDILERAKKKM-VLDHLVI--QRMDTTGKTVLHTGS-------APSSSTPFNKEELSAILKFGAE 974

  Fly   714 IPAKEP------PEQNNNTEMTKVNKAES------------------DIAAFFNDDDDEAFLE 752
            ...|||      |::.:..|:.|  :||:                  .:|.|.|.|:|:..||
Human   975 ELFKEPEGEEQEPQEMDIDEILK--RAETHENEPGPLTVGDELLSQFKVANFSNMDEDDIELE 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Marcal1	NP_608883.1	HARP	160..216	CDD:462166	14/84 (17%)
		HepA	<233..666	CDD:440319	127/507 (25%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	63/247 (26%)
CHD1	NP_001351042.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..252		27/123 (22%)
		CD1_tandem_CHD1-2_like	276..354	CDD:349313	15/96 (16%)
		CD2_tandem_CHD1-2_like	387..443	CDD:349308	7/55 (13%)
		DEAD-like_helicase_N	460..697	CDD:475120	66/268 (25%)
		PLN03142	464..>1000	CDD:215601	142/581 (24%)
		DEAH box	614..617		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1080..1120
		CDH1_2_SANT_HL1	1124..1210	CDD:477096
		DUF4208	1496..1586	CDD:464035
		U2AF_lg	1640..>1734	CDD:273727
		U2AF_lg	1688..>1797	CDD:273727
		HisXaaSer_A3	<1719..1750	CDD:439608