DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jet and FBXL15

DIOPT Version :9

Sequence 1:	NP_608880.2	Gene:	jet / 33705	FlyBaseID:	FBgn0031652	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	XP_005270206.1	Gene:	FBXL15 / 79176	HGNCID:	28155	Length:	387	Species:	Homo sapiens

Alignment Length:	269	Identity:	84/269 - (31%)
Similarity:	131/269 - (48%)	Gaps:	23/269 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DVCWDDVLIPQVAVYLSLKDLFNLRCCSRTAQRFVEAALEKRQELHLSGNNTKNID--------- 98
            |:.|:|||:|.|...:.|:.|..|:..||..:..|        :|||:|  .:..|
Human   108 DLPWEDVLLPHVLNRVPLRQLLRLQRVSRAFRSLV--------QLHLAG--LRRFDAAQVGPQIP 162

  Fly    99 -VAFRVLARCCQRLEVLHLA-CCRWLTDELLLPLLANNKKRLWAVNLNECVNITALSLQPIIVEC 161
             .|...|.|..:.|:.|.|| |..||:||.|:|:||.| .:|.:|.|..|..::..:|..:...|
Human   163 RAALARLLRDAEGLQELALAPCHEWLSDEDLVPVLARN-PQLRSVALGGCGQLSRRALGALAEGC 226

  Fly   162 KELRVLKLSKCQWLTTGAVDALTLHQSKLVEFDISYCGAIGERCLIIFFRKLNK-LTVLSLANTP 225
            ..|:.|.|:.|.|:...|:..|......|.|.|::.|..:.:..::...::... |..||||...
Human   227 PRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNA 291

  Fly   226 SVTDQVLIQIGNYCRELEHINVIGCAAISDYGVHALTVHCLRLRTLLIRRCPRVTELSLAPLRQR 290
            :|.|..:.::...|.||.|:::.||..:...||..|..:|..||:|.:|.|..|.|.||:.||:|
Human   292 NVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRLRKR 356

  Fly   291 RLYIDRPQP 299
            .:.||...|
Human   357 GVDIDVEPP 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jet	NP_608880.2	leucine-rich repeat	85..110	CDD:275381	8/34 (24%)
		AMN1	96..>261	CDD:187754	50/176 (28%)
		leucine-rich repeat	111..137	CDD:275381	14/26 (54%)
		leucine-rich repeat	138..163	CDD:275381	6/24 (25%)
		leucine-rich repeat	164..189	CDD:275381	7/24 (29%)
		leucine-rich repeat	190..215	CDD:275381	4/24 (17%)
		leucine-rich repeat	216..241	CDD:275381	8/24 (33%)
		leucine-rich repeat	242..267	CDD:275381	8/24 (33%)
		leucine-rich repeat	268..290	CDD:275381	11/21 (52%)
FBXL15	XP_005270206.1	F-box	105..>142	CDD:279040	12/33 (36%)
		leucine-rich repeat	149..175	CDD:275381	4/25 (16%)
		leucine-rich repeat	176..202	CDD:275381	14/26 (54%)
		leucine-rich repeat	203..228	CDD:275381	6/24 (25%)
		AMN1	<226..>353	CDD:187754	38/126 (30%)
		leucine-rich repeat	229..254	CDD:275381	7/24 (29%)
		leucine-rich repeat	255..281	CDD:275381	4/25 (16%)
		leucine-rich repeat	282..307	CDD:275381	8/24 (33%)
		leucine-rich repeat	308..332	CDD:275381	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44220
Inparanoid	1	1.050	117	1.000	Inparanoid score	I4818
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50180
OrthoDB	1	1.010	-	-		D1154571at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto91049
orthoMCL	1	0.900	-	-		OOG6_108979
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5025
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.910