DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment jet and FBXL19

DIOPT Version :9

Sequence 1:NP_608880.2 Gene:jet / 33705 FlyBaseID:FBgn0031652 Length:319 Species:Drosophila melanogaster
Sequence 2:NP_001093254.2 Gene:FBXL19 / 54620 HGNCID:25300 Length:694 Species:Homo sapiens


Alignment Length:284 Identity:73/284 - (25%)
Similarity:101/284 - (35%) Gaps:102/284 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 TRTASPRPLVTASIA--APRSLFDVCWDDVLIPQVAVYLSLKDLFNLRCCSRTAQRFVEAALEKR 84
            :|..|..|.:.:.:.  .||:| |:.|..|...|:...|:                    .|:..
Human   467 SRRKSLTPPMLSGVVRRQPRAL-DLSWTGVSKKQLMWLLN--------------------RLQGL 510

  Fly    85 QELHLSGNNTKNIDVAFRVLARCCQRLEVLHLACCRWLTD-------ELLLPL------LANNKK 136
            |||.|||.:..::.      |.....|..|.|...||:.|       |||||.      ...::.
Human   511 QELVLSGCSWLSVS------ALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRG 569

  Fly   137 RLWAVNLNECVNITALSLQPIIVECKELRVLKLSKCQWLTTGAVDALTLHQSKLVEFDISYCGAI 201
            ||..|                    .|||:..|.    ||..::..|..|..:|...|:|:|..:
Human   570 RLQGV--------------------AELRLAGLE----LTDASLRLLLRHAPQLSALDLSHCAHV 610

  Fly   202 GERCLIIFFRKLNKLTVLSLANTPSVTDQVLIQIGNYCRE-LEHINVIGCAAISDYGVHALTVHC 265
            |:                     |||  .:|....:..|| |.|:|:.||        |.||.||
Human   611 GD---------------------PSV--HLLTAPTSPLRETLVHLNLAGC--------HRLTDHC 644

  Fly   266 LRLRTLLIRRCPRVTELSLAPLRQ 289
            |.    |.|||||:..|.|...||
Human   645 LP----LFRRCPRLRRLDLRSCRQ 664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
jetNP_608880.2 leucine-rich repeat 85..110 CDD:275381 7/24 (29%)
AMN1 96..>261 CDD:187754 40/178 (22%)
leucine-rich repeat 111..137 CDD:275381 11/38 (29%)
leucine-rich repeat 138..163 CDD:275381 2/24 (8%)
leucine-rich repeat 164..189 CDD:275381 7/24 (29%)
leucine-rich repeat 190..215 CDD:275381 5/24 (21%)
leucine-rich repeat 216..241 CDD:275381 4/24 (17%)
leucine-rich repeat 242..267 CDD:275381 10/24 (42%)
leucine-rich repeat 268..290 CDD:275381 10/22 (45%)
FBXL19NP_001093254.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
zf-CXXC <50..77 CDD:251032
PHD_FXL19 87..148 CDD:277115
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..420
F-box-like 424..465 CDD:315592
leucine-rich repeat 461..485 CDD:275381 3/17 (18%)
AMN1 466..665 CDD:332986 73/284 (26%)
leucine-rich repeat 486..508 CDD:275381 7/42 (17%)
LRR 1 492..517 9/44 (20%)
leucine-rich repeat 510..533 CDD:275381 8/28 (29%)
LRR 2 518..541 4/28 (14%)
leucine-rich repeat 534..573 CDD:275381 12/38 (32%)
leucine-rich repeat 574..598 CDD:275381 9/47 (19%)
LRR 3 581..606 7/28 (25%)
leucine-rich repeat 599..623 CDD:275381 9/46 (20%)
LRR 4 607..636 11/51 (22%)
leucine-rich repeat 629..653 CDD:275381 15/35 (43%)
LRR 5 637..661 15/35 (43%)
leucine-rich repeat 654..686 CDD:275381 4/11 (36%)
LRR 6 662..694 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153005
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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