DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jet and fbxl15

DIOPT Version :9

Sequence 1:	NP_608880.2	Gene:	jet / 33705	FlyBaseID:	FBgn0031652	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_998107.1	Gene:	fbxl15 / 405878	ZFINID:	ZDB-GENE-040426-2440	Length:	296	Species:	Danio rerio

Alignment Length:	272	Identity:	76/272 - (27%)
Similarity:	137/272 - (50%)	Gaps:	26/272 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LFDVCWDDVLIPQVAVYLSLKDLFNLRCCSRTAQRFVEAALEKRQELHLSGNNTKNID------- 98
            |.|:.|:|||:..|..:|.|:.|.:|:..|::.:..::..|:          |.:..|
Zfish    16 LLDLPWEDVLVSHVFCHLPLRLLVSLQRVSKSFRSLIQVYLD----------NCRTFDPAQTGPH 70

  Fly    99 ---VAFRVLARCCQRLEVLHLA---CCRWLTDELLLPLLANNKKRLWAVNLNECVNITALSLQPI 157
               .||..:.|..|.|:  ||:   |..|:||..|||::..| ::|..|:|..|..::..:|..:
Zfish    71 IPREAFCSILRHNQVLQ--HLSVTNCSDWITDTDLLPVIGQN-QQLQHVDLRGCAQLSRRALVAV 132

  Fly   158 IVECKELRVLKLSKCQWLTTGAVDALTLHQSKLVEFDISYCGAIGERCLIIFFRKLNKLTVLSLA 222
            .:.|..|:.|.|:.|:|:.:.|:.:|..|...|...|::.|..:.:..:.....|..:|..||:|
Zfish   133 SLSCPRLQHLSLAHCEWVDSLALRSLADHCPMLRSLDLTACRQLKDPAVCYLAGKCPELRALSVA 197

  Fly   223 NTPSVTDQVLIQIGNYCRELEHINVIGCAAISDYGVHALTVHCLRLRTLLIRRCPRVTELSLAPL 287
            ...::||..:.::...|||:|.:::.||..:.:..:..|..:|.:|::|.:..|..|||.||..|
Zfish   198 VNANITDTAVEEVAKKCREMERLDLTGCLRVRNEAIRTLAEYCPKLQSLKVNHCHNVTESSLGVL 262

  Fly   288 RQRRLYIDRPQP 299
            |:|.:.||...|
Zfish   263 RRRNVEIDVEPP 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jet	NP_608880.2	leucine-rich repeat	85..110	CDD:275381	5/34 (15%)
		AMN1	96..>261	CDD:187754	46/177 (26%)
		leucine-rich repeat	111..137	CDD:275381	11/28 (39%)
		leucine-rich repeat	138..163	CDD:275381	6/24 (25%)
		leucine-rich repeat	164..189	CDD:275381	8/24 (33%)
		leucine-rich repeat	190..215	CDD:275381	4/24 (17%)
		leucine-rich repeat	216..241	CDD:275381	7/24 (29%)
		leucine-rich repeat	242..267	CDD:275381	5/24 (21%)
		leucine-rich repeat	268..290	CDD:275381	10/21 (48%)
fbxl15	NP_998107.1	F-box	16..>52	CDD:279040	12/35 (34%)
		leucine-rich repeat	51..85	CDD:275381	6/43 (14%)
		leucine-rich repeat	86..112	CDD:275381	11/28 (39%)
		AMN1	<111..272	CDD:187754	45/160 (28%)
		leucine-rich repeat	113..138	CDD:275381	6/24 (25%)
		LRR 1	138..159		6/20 (30%)
		leucine-rich repeat	139..164	CDD:275381	8/24 (33%)
		LRR 2	164..185		3/20 (15%)
		leucine-rich repeat	165..190	CDD:275381	4/24 (17%)
		LRR 3	190..211		6/20 (30%)
		leucine-rich repeat	191..216	CDD:275381	7/24 (29%)
		LRR 4	216..237		4/20 (20%)
		leucine-rich repeat	217..242	CDD:275381	5/24 (21%)
		LRR 5	242..263		8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	105	1.000	Domainoid score	I6564
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44220
Inparanoid	1	1.050	122	1.000	Inparanoid score	I4718
OMA	1	1.010	-	-		QHG50180
OrthoDB	1	1.010	-	-		D1154571at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto41481
orthoMCL	1	0.900	-	-		OOG6_108979
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5025
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.770