DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jet and Fbxl4

DIOPT Version :9

Sequence 1:	NP_608880.2	Gene:	jet / 33705	FlyBaseID:	FBgn0031652	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001382505.1	Gene:	Fbxl4 / 313101	RGDID:	1305724	Length:	621	Species:	Rattus norvegicus

Alignment Length:	320	Identity:	73/320 - (22%)
Similarity:	113/320 - (35%)	Gaps:	82/320 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LIPQVAVYLSLKDLFNL---------RCC-----------------SRTAQRFVEAALEKRQELH 88
            ||..:..:|||.||..|         .||                 ..|:..|::|.....|.|:
  Rat   287 LIQLILNHLSLPDLCRLAQTCRLLHQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQARCALVQWLN 351

  Fly    89 LSGNNTKN-IDVA--FRVLARCCQRLEVLHLACCRWLTDELL--------------------LPL 130
            ||....:. |.|:  .|.|..|...|..|.|:|..:|.|..|                    ||.
  Rat   352 LSWTGNRGFISVSGFSRFLKVCGSELVRLELSCSHFLNDACLEVISEMCPNLQDLNLSSCDKLPP 416

  Fly   131 LA-------NNKKRLWAVN-----------LNECVNITALSLQPIIV-------------ECKEL 164
            .|       .:.|||....           ||.|..:..|||...::             :||.|
  Rat   417 QAFGHIAKLRSLKRLILYRTKVEQTALLSILNFCAELQHLSLGSCVMIEDYDVIASMIGAKCKSL 481

  Fly   165 RVLKLSKCQWLTTGAVDALTLHQSKLVEFDISYCGAI--GERCLIIFFRKLNKLTVLSLANTPSV 227
            |.|.|.:|:.:|...:..|....:.|.|.|:.:|..:  ...|.....|:|..|..|.|....||
  Rat   482 RTLDLWRCKNITENGIAELASGCALLEELDLGWCPTLQSSTGCFARLARQLPNLQKLFLTANRSV 546

  Fly   228 TDQVLIQIGNYCRELEHINVIGCAAISDYGVHALTVHCLRLRTLLIRRCPRVTELSLAPL 287
            .|..:.::.:.|..|:.::::|...:|...:..|...|..|..|.:..|.::...::..|
  Rat   547 CDTDIEELASNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLEL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jet	NP_608880.2	leucine-rich repeat	85..110	CDD:275381	9/27 (33%)
		AMN1	96..>261	CDD:187754	50/220 (23%)
		leucine-rich repeat	111..137	CDD:275381	10/52 (19%)
		leucine-rich repeat	138..163	CDD:275381	8/48 (17%)
		leucine-rich repeat	164..189	CDD:275381	7/24 (29%)
		leucine-rich repeat	190..215	CDD:275381	7/26 (27%)
		leucine-rich repeat	216..241	CDD:275381	7/24 (29%)
		leucine-rich repeat	242..267	CDD:275381	5/24 (21%)
		leucine-rich repeat	268..290	CDD:275381	4/20 (20%)
Fbxl4	NP_001382505.1	F-box-like	280..318	CDD:403981	10/30 (33%)
		leucine-rich repeat	295..317	CDD:275381	8/21 (38%)
		leucine-rich repeat	318..340	CDD:275381	1/21 (5%)
		leucine-rich repeat	347..376	CDD:275381	9/28 (32%)
		leucine-rich repeat	377..402	CDD:275381	7/24 (29%)
		AMN1	394..601	CDD:187754	43/206 (21%)
		leucine-rich repeat	403..427	CDD:275381	3/23 (13%)
		leucine-rich repeat	428..452	CDD:275381	6/23 (26%)
		leucine-rich repeat	453..480	CDD:275381	4/26 (15%)
		leucine-rich repeat	481..506	CDD:275381	7/24 (29%)
		leucine-rich repeat	507..534	CDD:275381	7/26 (27%)
		leucine-rich repeat	535..560	CDD:275381	7/24 (29%)
		leucine-rich repeat	561..586	CDD:275381	5/24 (21%)
		leucine-rich repeat	587..612	CDD:275381	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900