DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jet and Fbxl15

DIOPT Version :9

Sequence 1:	NP_608880.2	Gene:	jet / 33705	FlyBaseID:	FBgn0031652	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001101073.1	Gene:	Fbxl15 / 309453	RGDID:	1306444	Length:	300	Species:	Rattus norvegicus

Alignment Length:	261	Identity:	80/261 - (30%)
Similarity:	131/261 - (50%)	Gaps:	3/261 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LFDVCWDDVLIPQVAVYLSLKDLFNLRCCSRTAQRFVEAALEKRQELHLSGNNTKNIDVAFRVLA 105
            |.|:.|:|||:|.|..::.|:.|..|:..||..:..|:..|.:.:....:....:....|...|.
  Rat    19 LLDLPWEDVLLPHVLNWVPLRQLLRLQRVSRAFRALVQLHLARLRRFDAAQVGPQIPRAALVRLL 83

  Fly   106 RCCQRLEVLHLA-CCRWLTDELLLPLLANNKKRLWAVNLNECVNITALSLQPIIVECKELRVLKL 169
            |..:.|:.|.|| |..||.||.|:|:||.| .:|.:|.|..|..::..:|..:...|..|:.:.|
  Rat    84 RDAEGLQELALAPCHEWLLDEDLVPVLARN-PQLRSVALAGCGQLSRRALGALAEGCPRLQRISL 147

  Fly   170 SKCQWLTTGAVDALTLHQSKLVEFDISYCGAIGERCLIIFFRKLNK-LTVLSLANTPSVTDQVLI 233
            :.|.|:...|:..|......|.|.|::.|..:.:..::...::... |..||||...:|.|..:.
  Rat   148 AHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDTAVQ 212

  Fly   234 QIGNYCRELEHINVIGCAAISDYGVHALTVHCLRLRTLLIRRCPRVTELSLAPLRQRRLYIDRPQ 298
            ::...|.:|||:::.||..:...||..|..:|..||:|.:|.|..|.|.||:.||:|.:.||...
  Rat   213 ELARNCPQLEHLDLTGCLRVGSDGVRTLAEYCPALRSLRVRHCHHVAEPSLSRLRKRGVDIDVEP 277

  Fly   299 P 299
            |
  Rat   278 P 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jet	NP_608880.2	leucine-rich repeat	85..110	CDD:275381	3/24 (13%)
		AMN1	96..>261	CDD:187754	48/166 (29%)
		leucine-rich repeat	111..137	CDD:275381	14/26 (54%)
		leucine-rich repeat	138..163	CDD:275381	6/24 (25%)
		leucine-rich repeat	164..189	CDD:275381	6/24 (25%)
		leucine-rich repeat	190..215	CDD:275381	4/24 (17%)
		leucine-rich repeat	216..241	CDD:275381	8/24 (33%)
		leucine-rich repeat	242..267	CDD:275381	9/24 (38%)
		leucine-rich repeat	268..290	CDD:275381	11/21 (52%)
Fbxl15	NP_001101073.1	F-box	18..55	CDD:395521	13/35 (37%)
		leucine-rich repeat	62..88	CDD:275381	3/25 (12%)
		leucine-rich repeat	89..115	CDD:275381	14/26 (54%)
		Interaction with SMURF1. /evidence=ECO:0000250	113..269		45/156 (29%)
		leucine-rich repeat	116..141	CDD:275381	6/24 (25%)
		AMN1	<139..>268	CDD:187754	38/128 (30%)
		leucine-rich repeat	142..167	CDD:275381	6/24 (25%)
		leucine-rich repeat	168..194	CDD:275381	4/25 (16%)
		leucine-rich repeat	195..220	CDD:275381	8/24 (33%)
		leucine-rich repeat	221..245	CDD:275381	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44220
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4690
OMA	1	1.010	-	-		QHG50180
OrthoDB	1	1.010	-	-		D1154571at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto98143
orthoMCL	1	0.900	-	-		OOG6_108979
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.740