DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment jet and FBXL4

DIOPT Version :9

Sequence 1:NP_608880.2 Gene:jet / 33705 FlyBaseID:FBgn0031652 Length:319 Species:Drosophila melanogaster
Sequence 2:NP_001265645.1 Gene:FBXL4 / 26235 HGNCID:13601 Length:621 Species:Homo sapiens


Alignment Length:269 Identity:66/269 - (24%)
Similarity:100/269 - (37%) Gaps:86/269 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 LIPQVAVYLSLKDLFNL---------RCC-----------------SRTAQRFVEAALEKRQELH 88
            ||..:..:|:|.||..|         .||                 ..|:..|:::.....|.|:
Human   287 LIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLN 351

  Fly    89 LSGNNTKN-IDVA--FRVLARCCQRLEVLHLACCRWLTDELLLPLLANNKKRLWAVNLNECVNIT 150
            ||....:. |.||  .|.|..|...|..|.|:|..:|.:                    .|    
Human   352 LSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNE--------------------TC---- 392

  Fly   151 ALSLQPIIVECKELRVLKLSKCQWLTTGAVDALTLHQSKLVEFDISYCGAIGERCLIIFFRKLNK 215
               |:.|...|..|:.|.||.|..|...|.:    |.:||...          :.|:::..|:.:
Human   393 ---LEVISEMCPNLQALNLSSCDKLPPQAFN----HIAKLCSL----------KRLVLYRTKVEQ 440

  Fly   216 LTVLSLANTPSVTDQVLIQIGNYCRELEHINVIGCAAISDYGVHA--LTVHCLRLRTLLIRRCPR 278
            ..:||:.              |:|.||:|:::..|..|.||.|.|  :...|.:||||.:.||..
Human   441 TALLSIL--------------NFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKN 491

  Fly   279 VTELSLAPL 287
            :||..:|.|
Human   492 ITENGIAEL 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
jetNP_608880.2 leucine-rich repeat 85..110 CDD:275381 10/27 (37%)
AMN1 96..>261 CDD:187754 40/169 (24%)
leucine-rich repeat 111..137 CDD:275381 5/25 (20%)
leucine-rich repeat 138..163 CDD:275381 4/24 (17%)
leucine-rich repeat 164..189 CDD:275381 8/24 (33%)
leucine-rich repeat 190..215 CDD:275381 3/24 (13%)
leucine-rich repeat 216..241 CDD:275381 4/24 (17%)
leucine-rich repeat 242..267 CDD:275381 9/26 (35%)
leucine-rich repeat 268..290 CDD:275381 10/20 (50%)
FBXL4NP_001265645.1 F-box-like 280..318 CDD:315592 9/30 (30%)
leucine-rich repeat 295..317 CDD:275381 7/21 (33%)
leucine-rich repeat 318..346 CDD:275381 2/27 (7%)
leucine-rich repeat 347..376 CDD:275381 10/28 (36%)
LRR 1 376..397 7/47 (15%)
leucine-rich repeat 377..398 CDD:275381 8/47 (17%)
AMN1 394..601 CDD:332986 38/135 (28%)
LRR 2 402..421 7/22 (32%)
leucine-rich repeat 403..427 CDD:275381 10/27 (37%)
LRR 3 427..448 4/44 (9%)
leucine-rich repeat 428..452 CDD:275381 6/47 (13%)
LRR 4 452..474 9/21 (43%)
leucine-rich repeat 453..480 CDD:275381 9/26 (35%)
LRR 5 480..501 10/21 (48%)
leucine-rich repeat 481..506 CDD:275381 10/20 (50%)
LRR 6 504..524
leucine-rich repeat 507..534 CDD:275381
LRR 7 532..558
leucine-rich repeat 535..560 CDD:275381
LRR 8 559..583
leucine-rich repeat 561..586 CDD:275381
LRR 9 584..609
leucine-rich repeat 587..612 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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