DRSC/TRiP Functional Genomics Resources

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Protein Alignment jet and FBXL7

DIOPT Version :9

Sequence 1:NP_608880.2 Gene:jet / 33705 FlyBaseID:FBgn0031652 Length:319 Species:Drosophila melanogaster
Sequence 2:NP_036436.1 Gene:FBXL7 / 23194 HGNCID:13604 Length:491 Species:Homo sapiens


Alignment Length:369 Identity:87/369 - (23%)
Similarity:145/369 - (39%) Gaps:96/369 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 MAMASGGQPTRTASPRPLVTASIAAPRSLFDVCWDDVLIPQVAVYLSLKDLFNLRC-CSRTAQRF 76
            :||.....|||...|...:.:.....::..|...|..:: |:..:|....|    | |:|..:|:
Human    85 VAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMV-QIFSFLPTNQL----CRCARVCRRW 144

  Fly    77 VEAALEKR--QELHLSGNNTKNIDVAFRVLAR--C------CQRLEVLHLACCRWLTDELLLPL- 130
            ...|.:.|  :.:.|:| .|.|:|.|.:||.|  |      |..||.:.::.||.|||..|..: 
Human   145 YNLAWDPRLWRTIRLTG-ETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIA 208

  Fly   131 ---------------------------LANNKKRLWAVNLNECVNITALS--------------- 153
                                       |..|.:.|   :::.|..:|.:|               
Human   209 QCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHL---DVSGCSKVTCISLTREASIKLSPLHGK 270

  Fly   154 -------------------LQPIIVECKELRVLKLSKCQWLTTGAVDALTLHQSKLVEFDISYCG 199
                               |..|...|.:|..|.|.:|..||...:..|.::.:.:.|..:|.|.
Human   271 QISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCR 335

  Fly   200 AIGERCLIIFFRKLNKLTVLSLANTPSVTDQVLIQIGNYCRELEHINVIGCAAISDYGVHALTVH 264
            .:.:..|....:..::|..||:|:...|||..:..:..||.:|.::|..||..|:|:||..|..:
Human   336 FVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKN 400

  Fly   265 CLRLRTLLIRRCPRVTELSLAPLRQRRLYIDRPQPDVGLNAYNL 308
            |.:|::|.|.:||.|::..|..|              .||.:||
Human   401 CTKLKSLDIGKCPLVSDTGLECL--------------ALNCFNL 430

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
jetNP_608880.2 leucine-rich repeat 85..110 CDD:275381 11/32 (34%)
AMN1 96..>261 CDD:187754 53/234 (23%)
leucine-rich repeat 111..137 CDD:275381 10/53 (19%)
leucine-rich repeat 138..163 CDD:275381 7/58 (12%)
leucine-rich repeat 164..189 CDD:275381 7/24 (29%)
leucine-rich repeat 190..215 CDD:275381 4/24 (17%)
leucine-rich repeat 216..241 CDD:275381 9/24 (38%)
leucine-rich repeat 242..267 CDD:275381 10/24 (42%)
leucine-rich repeat 268..290 CDD:275381 8/21 (38%)
FBXL7NP_036436.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79
F-box-like 114..157 CDD:372399 11/47 (23%)
leucine-rich repeat 129..151 CDD:275381 7/25 (28%)
leucine-rich repeat 154..187 CDD:275381 11/33 (33%)
LRR 1 170..195 7/24 (29%)
AMN1 <185..366 CDD:187754 35/183 (19%)
leucine-rich repeat 188..213 CDD:275381 8/24 (33%)
LRR 2 196..221 6/24 (25%)
leucine-rich repeat 214..234 CDD:275381 0/19 (0%)
LRR 3 222..247 3/27 (11%)
leucine-rich repeat 240..273 CDD:275381 4/35 (11%)
LRR 4 253..281 1/27 (4%)
leucine-rich repeat 274..299 CDD:275381 3/24 (13%)
LRR 5 282..307 6/24 (25%)
AMN1 297..464 CDD:187754 43/148 (29%)
leucine-rich repeat 300..325 CDD:275381 7/24 (29%)
LRR 6 308..333 5/24 (21%)
leucine-rich repeat 326..351 CDD:275381 4/24 (17%)
LRR 7 334..359 5/24 (21%)
leucine-rich repeat 352..377 CDD:275381 9/24 (38%)
LRR 8 360..385 7/24 (29%)
leucine-rich repeat 378..403 CDD:275381 10/24 (42%)
LRR 9 386..411 10/24 (42%)
leucine-rich repeat 404..429 CDD:275381 10/38 (26%)
LRR 10 412..437 9/33 (27%)
leucine-rich repeat 430..453 CDD:275381 1/1 (100%)
LRR 11 438..463
leucine-rich repeat 456..480 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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