DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment jet and Kdm2a

DIOPT Version :9

Sequence 1:NP_608880.2 Gene:jet / 33705 FlyBaseID:FBgn0031652 Length:319 Species:Drosophila melanogaster
Sequence 2:NP_001001984.2 Gene:Kdm2a / 225876 MGIID:1354736 Length:1161 Species:Mus musculus


Alignment Length:272 Identity:65/272 - (23%)
Similarity:96/272 - (35%) Gaps:85/272 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 YLSLKDLFNLR---------CCSR---------TAQRFVEAALE---KRQ--ELHLSGNNTKNID 98
            |||.|:|....         ||.:         ..:..|..||.   |||  .|.||..|.....
Mouse   903 YLSRKELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQ 967

  Fly    99 VAFRVLARCCQRLEVLHLACCRWLTDELL----LPLLANNKKRLWAVNLNE-------------- 145
            :.:  |......|:.|.||.|.|.....|    .|||.....| |||.:.:              
Mouse   968 LTW--LVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLR-WAVGIKDPQIRDLLTPPTDKP 1029

  Fly   146 -----------------CVNITALSLQPIIVECKELRVLKLSKCQWLTTGAVDALTLHQS----K 189
                             .::||..:|:.||.....|..|.||.|..||..:.:.||...|    .
Mouse  1030 GQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYS 1094

  Fly   190 LVEFDISYCGAIGERCLIIFFRKLNKLTVLSLANTPSVTDQVLIQIGNYCRELEHINVIGCAAIS 254
            |.|.:::.|..:.::.| .|.|::..:|::.|.....:|.:.       |   ||.       ||
Mouse  1095 LTELNMAGCNKLTDQTL-FFLRRIANVTLIDLRGCKQITRKA-------C---EHF-------IS 1141

  Fly   255 DYGVHALTVHCL 266
            |..:::|  :||
Mouse  1142 DLSINSL--YCL 1151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
jetNP_608880.2 leucine-rich repeat 85..110 CDD:275381 6/26 (23%)
AMN1 96..>261 CDD:187754 45/203 (22%)
leucine-rich repeat 111..137 CDD:275381 10/29 (34%)
leucine-rich repeat 138..163 CDD:275381 8/55 (15%)
leucine-rich repeat 164..189 CDD:275381 10/28 (36%)
leucine-rich repeat 190..215 CDD:275381 6/24 (25%)
leucine-rich repeat 216..241 CDD:275381 4/24 (17%)
leucine-rich repeat 242..267 CDD:275381 8/25 (32%)
leucine-rich repeat 268..290 CDD:275381
Kdm2aNP_001001984.2 cupin_like 199..299 CDD:389752
JHD 304..>339 CDD:375347
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..445
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..557
zf-CXXC <576..609 CDD:366873
PHD_KDM2A 619..675 CDD:277113
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 705..789
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 840..886
F-box-like 895..933 CDD:372399 7/29 (24%)
leucine-rich repeat 929..953 CDD:275381 5/23 (22%)
AMN1 931..1137 CDD:187754 50/219 (23%)
leucine-rich repeat 954..977 CDD:275381 5/24 (21%)
LRR 1 960..981 3/22 (14%)
leucine-rich repeat 978..1001 CDD:275381 7/22 (32%)
LRR 2 983..1009 9/26 (35%)
leucine-rich repeat 1002..1039 CDD:275381 5/37 (14%)
leucine-rich repeat 1040..1064 CDD:275381 5/23 (22%)
LRR 3 1047..1072 8/24 (33%)
leucine-rich repeat 1065..1094 CDD:275381 10/28 (36%)
LRR 4 1073..1102 8/28 (29%)
leucine-rich repeat 1095..1119 CDD:275381 6/24 (25%)
LRR 5 1103..1127 6/24 (25%)
leucine-rich repeat 1120..1139 CDD:275381 5/28 (18%)
LRR 6 1128..1155 10/43 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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