DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jet and AMN1

DIOPT Version :9

Sequence 1:	NP_608880.2	Gene:	jet / 33705	FlyBaseID:	FBgn0031652	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_001106873.1	Gene:	AMN1 / 196394	HGNCID:	27281	Length:	258	Species:	Homo sapiens

Alignment Length:	191	Identity:	54/191 - (28%)
Similarity:	90/191 - (47%)	Gaps:	17/191 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 EVLH-------LACCRWLTDELLLPLLANNKKRLWAVNLNEC----VNITALSLQPIIVECKELR 165
            |:||       |..|. ::|..||.|  :|.::|..:|||..    |::|:..::.:...|..|.
Human    57 EILHPEVQTLDLRSCD-ISDAALLHL--SNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLH 118

  Fly   166 VLKLSKCQWLTTGAVDALTLHQSKLVEFDISYCGAIGERCLIIFFRKLNKLTVLSLANTPSVTDQ 230
            ...|.:|..||...|.||.|:...|...|:..|.:|.:..|....:....|..:..:.| .|:|.
Human   119 EASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSAT-QVSDS 182

  Fly   231 VLIQI--GNYCRELEHINVIGCAAISDYGVHALTVHCLRLRTLLIRRCPRVTELSLAPLRQ 289
            .:|.:  |...::||.|::..|..::|..|.|:..:|.::|.||...||.:|:.|...|.|
Human   183 GVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREVLEQ 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jet	NP_608880.2	leucine-rich repeat	85..110	CDD:275381
		AMN1	96..>261	CDD:187754	43/161 (27%)
		leucine-rich repeat	111..137	CDD:275381	10/31 (32%)
		leucine-rich repeat	138..163	CDD:275381	7/28 (25%)
		leucine-rich repeat	164..189	CDD:275381	9/24 (38%)
		leucine-rich repeat	190..215	CDD:275381	5/24 (21%)
		leucine-rich repeat	216..241	CDD:275381	6/26 (23%)
		leucine-rich repeat	242..267	CDD:275381	8/24 (33%)
		leucine-rich repeat	268..290	CDD:275381	9/22 (41%)
AMN1	NP_001106873.1	AMN1	37..257	CDD:187754	54/191 (28%)
		leucine-rich repeat	63..86	CDD:275381	7/25 (28%)
		leucine-rich repeat	87..116	CDD:275381	7/28 (25%)
		leucine-rich repeat	117..142	CDD:275381	9/24 (38%)
		leucine-rich repeat	143..168	CDD:275381	5/24 (21%)
		leucine-rich repeat	169..195	CDD:275381	6/26 (23%)
		leucine-rich repeat	196..221	CDD:275381	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900