DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jet and FBXO39

DIOPT Version :9

Sequence 1:	NP_608880.2	Gene:	jet / 33705	FlyBaseID:	FBgn0031652	Length:	319	Species:	Drosophila melanogaster
Sequence 2:	NP_694962.1	Gene:	FBXO39 / 162517	HGNCID:	28565	Length:	442	Species:	Homo sapiens

Alignment Length:	242	Identity:	49/242 - (20%)
Similarity:	83/242 - (34%)	Gaps:	67/242 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 CW---DDVLIPQVAVYLSLKDLFNLR-CCSRTAQRFVEAALEKRQELHLSGN----NTKNIDVA- 100
            ||   .|:.:.:|..:|..:|..... .|.:..|....|.|.:.:.:..||.    :...::.|
Human    15 CWAFLPDLCLCRVFWWLGDRDRSRAALVCRKWNQMMYSAELWRYRTITFSGRPSRVHASEVESAV 79

  Fly   101 --FRVLARCCQRLEVLH-------LACCRWLTDELLLPLLANNKKRLWAVNLNECVNITALSLQP 156
              .:...|..:.|||..       |.....:|...||..|:.:..||           .:||:|
Human    80 WYVKKFGRYLEHLEVKFMNPYNAVLTKKFQVTMRGLLSCLSKSNNRL-----------KSLSIQ- 132

  Fly   157 IIVECKELRVLKLSKCQW---LTTGAVDALTLHQSKLVEFDISYCGAIGERCLIIFFRKLNK-LT 217
                     .|:|.:..|   :.:..:.:|:                       .|.:|:.| |.
Human   133 ---------YLELDRLVWRNSIRSSFISSLS-----------------------FFLKKMGKRLD 165

  Fly   218 VLSLANTPSVTDQVLIQIGNYCRELEHINVIGCAAISDYGVHALTVH 264
            .|:|.......:|. .||.:....:.:.|||....|.||..|.|.|:
Human   166 YLNLKGARLTVEQG-CQILDSLSYMRNENVISELNIEDYFSHHLAVY 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jet	NP_608880.2	leucine-rich repeat	85..110	CDD:275381	4/31 (13%)
		AMN1	96..>261	CDD:187754	35/178 (20%)
		leucine-rich repeat	111..137	CDD:275381	8/32 (25%)
		leucine-rich repeat	138..163	CDD:275381	4/24 (17%)
		leucine-rich repeat	164..189	CDD:275381	4/27 (15%)
		leucine-rich repeat	190..215	CDD:275381	2/24 (8%)
		leucine-rich repeat	216..241	CDD:275381	6/24 (25%)
		leucine-rich repeat	242..267	CDD:275381	9/23 (39%)
		leucine-rich repeat	268..290	CDD:275381
FBXO39	NP_694962.1	F-box-like	16..57	CDD:289689	9/40 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900