DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaggt-I and CDC43

DIOPT Version :9

Sequence 1:	NP_525100.2	Gene:	betaggt-I / 33704	FlyBaseID:	FBgn0015000	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_011360.1	Gene:	CDC43 / 852722	SGDID:	S000003123	Length:	376	Species:	Saccharomyces cerevisiae

Alignment Length:	379	Identity:	112/379 - (29%)
Similarity:	159/379 - (41%)	Gaps:	94/379 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLLSKHAKNLLRFLNLLPARMASHDNTRSTIVFFAVCGLDVLNSLHLVPPQLRQ-DIIDWI---Y 70
            |:..||.|...|.|.|||:....||..|..|:|:::.||.:.:    |....:. |.:.|:   |
Yeast    11 VVTKKHRKFFERHLQLLPSSHQGHDVNRMAIIFYSISGLSIFD----VNVSAKYGDHLGWMRKHY 71

  Fly    71 GGLVVPRDNEKNCGGFMGCRAM---------VPKTEDAEI-LECMRNYQWGHLAMTYTSLAVLVT 125
            ...|:.........||:|...|         :|.|..|.: :..:|:|::            ..|
Yeast    72 IKTVLDDTENTVISGFVGSLVMNIPHATTINLPNTLFALLSMIMLRDYEY------------FET 124

  Fly   126 LGDDLSRLDRKSIVDGVAAVQKPE-GSFSACID-----GS---EDDMRFVYCAATICYMLDYWGD 181
            :      ||::|:...|:..|:|: |||.:|:|     ||   .||:||.|.|..|.|:.   |.
Yeast   125 I------LDKRSLARFVSKCQRPDRGSFVSCLDYKTNCGSSVDSDDLRFCYIAVAILYIC---GC 180

  Fly   182 VNKETMFQFITRSLRYDYGFSQE-------LEGEAHGGTTFCALAALHLSGQLHRLDATTVERMK 239
            .:||...::|.......|..||:       ...|.|.|.|.|||:.|.|...|.:|.....|...
Yeast   181 RSKEDFDEYIDTEKLLGYIMSQQCYNGAFGAHNEPHSGYTSCALSTLALLSSLEKLSDKFKEDTI 245

  Fly   240 RWLIFRQMD---------------------GFQGRPNKPVDTCYSFWIGASLCILD-------GF 276
            .||:.||:.                     |||||.||..||||:||...||.:|.       ..
Yeast   246 TWLLHRQVSSHGCMKFESELNASYDQSDDGGFQGRENKFADTCYAFWCLNSLHLLTKDWKMLCQT 310

  Fly   277 EL-TDYARNREFILSTQDKLIGGFAKWPQATPDPFHTYLGLCGLA-----FTGE 324
            || |:|..:|     ||..|.|||:|..:...|.:|:.||...||     |.||
Yeast   311 ELVTNYLLDR-----TQKTLTGGFSKNDEEDADLYHSCLGSAALALIEGKFNGE 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaggt-I	NP_525100.2	CAL1	10..336	CDD:227362	112/379 (30%)
betaggt-I	NP_525100.2	GGTase-I	14..321	CDD:239225	108/370 (29%)
CDC43	NP_011360.1	CAL1	1..376	CDD:227362	112/379 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5029
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54575
OrthoFinder	1	1.000	-	-		FOG0005480
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103705
Panther	1	1.100	-	-	LDO	PTHR11774
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R918
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.740