DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaggt-I and PGGT1B

DIOPT Version :9

Sequence 1:	NP_525100.2	Gene:	betaggt-I / 33704	FlyBaseID:	FBgn0015000	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	XP_011541792.1	Gene:	PGGT1B / 5229	HGNCID:	8895	Length:	408	Species:	Homo sapiens

Alignment Length:	350	Identity:	158/350 - (45%)
Similarity:	228/350 - (65%)	Gaps:	6/350 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLSKHAKNLLRFLNLLPARMASHDNTRSTIVFFAVCGLDVLNSLHLVPPQLRQDIIDWIYGGLVV 75
            |..:|.:...|.|.:||.|.:|.:.:|.||.|||:.|||:|:||.:|.   :.|||:|||...|:
Human    21 LRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVN---KDDIIEWIYSLQVL 82

  Fly    76 PRDNEKNCG--GFMGCRAMVPKTEDAEILECMRNYQWGHLAMTYTSLAVLVTLGDDLSRLDRKSI 138
            |.::..|..  ||.|...:......::.......|..||:|||||.|:.||.|||||||:::::.
Human    83 PTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEAC 147

  Fly   139 VDGVAAVQKPEGSFSACIDGSEDDMRFVYCAATICYMLDYWGDVNKETMFQFITRSLRYDYGFSQ 203
            :.|:.|:|..:|||.|..:|||:||||||||:.|||||:.|..::.:....:|.||:.||.|.:|
Human   148 LAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQ 212

  Fly   204 ELEGEAHGGTTFCALAALHLSGQLHRL-DATTVERMKRWLIFRQMDGFQGRPNKPVDTCYSFWIG 267
            ....|:|||:|||.:|:|.|.|:|..: ....:.|:|||.|.||.:|:.||||||||||||||:|
Human   213 GAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVG 277

  Fly   268 ASLCILDGFELTDYARNREFILSTQDKLIGGFAKWPQATPDPFHTYLGLCGLAFTGEPGLSPVNP 332
            |:|.:|..|:.|::.:||.:||||||:|:|||||||.:.||..|.|.|:|||:...|.|:..|:|
Human   278 ATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHP 342

  Fly   333 SLNMSMAAYAHLQHLHEQWRSADGR 357
            :||:|......|..||:.|::.|.:
Human   343 ALNVSTRTSERLLDLHQSWKTKDSK 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaggt-I	NP_525100.2	CAL1	10..336	CDD:227362	151/327 (46%)
betaggt-I	NP_525100.2	GGTase-I	14..321	CDD:239225	145/309 (47%)
PGGT1B	XP_011541792.1	GGTase-I	22..332	CDD:239225	145/312 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141013
Domainoid	1	1.000	86	1.000	Domainoid score	I8152
eggNOG	1	0.900	-	-		E1_COG5029
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3685
Inparanoid	1	1.050	320	1.000	Inparanoid score	I2532
Isobase	1	0.950	-	0	Normalized mean entropy	S1849
OMA	1	1.010	-	-		QHG54575
OrthoDB	1	1.010	-	-		D1042804at2759
OrthoFinder	1	1.000	-	-		FOG0005480
OrthoInspector	1	1.000	-	-		oto88476
orthoMCL	1	0.900	-	-		OOG6_103705
Panther	1	1.100	-	-	LDO	PTHR11774
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R918
SonicParanoid	1	1.000	-	-		X4430
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750