DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaggt-I and Rabggtb

DIOPT Version :9

Sequence 1:	NP_525100.2	Gene:	betaggt-I / 33704	FlyBaseID:	FBgn0015000	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_619715.2	Gene:	Rabggtb / 25533	RGDID:	3530	Length:	331	Species:	Rattus norvegicus

Alignment Length:	344	Identity:	102/344 - (29%)
Similarity:	159/344 - (46%)	Gaps:	59/344 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DRTDTEPVLLSKHAKNLLRFLNLLPARMASH------------DNTRSTIVFFAVCGLDVLNSLH 55
            |..||  :||.|||..:           ||:            :..|.:.|::.:..:|::..||
  Rat    13 DAPDT--LLLEKHADYI-----------ASYGSKKDDYEYCMSEYLRMSGVYWGLTVMDLMGQLH 64

  Fly    56 LVPPQLRQDIIDWIYGGLVVPRDNEKNCGGFMGCRAMVPKTEDAEILECMRNYQWGHLAMTYTSL 120
                ::.::.|      ||..:..:..|||........|                 ||..|.:::
  Rat    65 ----RMNKEEI------LVFIKSCQHECGGVSASIGHDP-----------------HLLYTLSAV 102

  Fly   121 AVLVTLGDDLSRLDRKSIVDGVAAVQKPEGSFSACIDGSEDDMRFVYCAATICYMLDYWGDVNKE 185
            .:| ||.|.:..::...:|..|.::||.:|||:..|.| |.|.||.:||.....:|.....:|.|
  Rat   103 QIL-TLYDSIHVINVDKVVAYVQSLQKEDGSFAGDIWG-EIDTRFSFCAVATLALLGKLDAINVE 165

  Fly   186 TMFQFITRSLRYDYGFSQELEGEAHGGTTFCALAALHLSGQLHRLDATTVERMKRWLIFRQM--D 248
            ...:|:...:.:|.||......|:|.|..:|....|.::.|||::::   :.:..||..||:  .
  Rat   166 KAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNS---DLLGWWLCERQLPSG 227

  Fly   249 GFQGRPNKPVDTCYSFWIGASLCILDGFELTDYARNREFILSTQDKLIGGFAKWPQATPDPFHTY 313
            |..|||.|..|.|||:|:.|||.|:......|..:.|.|||:.||:..||||..|....|||||.
  Rat   228 GLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTL 292

  Fly   314 LGLCGLAFTGEPGLSPVNP 332
            .|:.||:..||..:.||:|
  Rat   293 FGIAGLSLLGEEQIKPVSP 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaggt-I	NP_525100.2	CAL1	10..336	CDD:227362	99/337 (29%)
betaggt-I	NP_525100.2	GGTase-I	14..321	CDD:239225	92/320 (29%)
Rabggtb	NP_619715.2	GGTase-II	18..301	CDD:239224	94/325 (29%)
		PFTB 1	20..61		9/51 (18%)
		PFTB 2	68..109		13/64 (20%)
		PFTB 3	116..157		15/41 (37%)
		PFTB 4	164..205		10/40 (25%)
		Geranylgeranyl diphosphate binding	190..192		1/1 (100%)
		PFTB 5	212..253		18/43 (42%)
		Geranylgeranyl diphosphate binding	232..244		7/11 (64%)
		PFTB 6	260..302		19/41 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1042804at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820