DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sgs1 and MUC16

DIOPT Version :9

Sequence 1:NP_523475.3 Gene:Sgs1 / 33701 FlyBaseID:FBgn0003372 Length:1286 Species:Drosophila melanogaster
Sequence 2:NP_078966.2 Gene:MUC16 / 94025 HGNCID:15582 Length:14507 Species:Homo sapiens


Alignment Length:1577 Identity:437/1577 - (27%)
Similarity:593/1577 - (37%) Gaps:433/1577 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 IQVKNVKANYDWDSMQ------DGPSEEI--IP--GCGGDTIYYPDPVQPCDTDSNPTTTKPRQK 69
            :::..|.:.|...|:.      ||..|.|  ||  .....||   .||:...|.::|.:.|....
Human 10405 VELGTVTSAYQVPSLSTRLTRTDGIMEHITKIPNEAAHRGTI---RPVKGPQTSTSPASPKGLHT 10466

  Fly    70 --TKRPKSTRRTTKRTKRPRRKTTKWTTKRATKRTTKRT--------------------TRRRPT 112
              |||.::|....|.|     .|...||.|||..|:..|                    |....|
Human 10467 GGTKRMETTTTALKTT-----TTALKTTSRATLTTSVYTPTLGTLTPLNASMQMASTIPTEMMIT 10526

  Fly   113 T----PKTPDTTDSPITTTGAE-CTCSDRTTAS--STDSTTDRTTV------------------- 151
            |    |..|:||.|..|:.||| .|...|||.|  :.:|.|..:.|                   
Human 10527 TPYVFPDVPETTSSLATSLGAETSTALPRTTPSVFNRESETTASLVSRSGAERSPVIQTLDVSSS 10591

  Fly   152 ---TNTDW------TTPLCTDTPPCTCSEE----SSTAIPSSPCIDTSTVIPT--SPCTQETTTP 201
               |...|      |.|..:.|.|.....|    ||||  :|...|.|:.|||  ||...:..||
Human 10592 EPDTTASWVIHPAETIPTVSKTTPNFFHSELDTVSSTA--TSHGADVSSAIPTNISPSELDALTP 10654

  Fly   202 TPTCSTQGTQTTPCTCAQT--TTTPRSTTTTSTSRPTTTTPRS---------------------- 242
            ..|.|...|.||..|..::  .|..|:|..|..:..::|.||:                      
Human 10655 LVTISGTDTSTTFPTLTKSPHETETRTTWLTHPAETSSTIPRTIPNFSHHESDATPSIATSPGAE 10719

  Fly   243 ----------------------------------TTTTTTSRPTT-----TTPRSTTT----TTT 264
                                              |.|.:...|.|     |.|.:.|:    |:|
Human 10720 TSSAIPIMTVSPGAEDLVTSQVTSSGTDRNMTIPTLTLSPGEPKTIASLVTHPEAQTSSAIPTST 10784

  Fly   265 RRPTTTTPRCTTTTSTCAPTTTTPR---------STTTTTTSRPTTTTPRCTTTTSTC--SPTRT 318
            ..|..:....:..||..|.|:||.|         :||.:..:.|..|:|....|||..  |.:.|
Human 10785 ISPAVSRLVTSMVTSLAAKTSTTNRALTNSPGEPATTVSLVTHPAQTSPTVPWTTSIFFHSKSDT 10849

  Fly   319 TPRSTT-------------TTSTSRPTTTTPRCTT------------TPSTSRPTTTTPRSTT-- 356
            ||..||             |.||..|...||..|:            |.|...|.||...:|:  
Human 10850 TPSMTTSHGAESSSAVPTPTVSTEVPGVVTPLVTSSRAVISTTIPILTLSPGEPETTPSMATSHG 10914

  Fly   357 -KTSTCAPTTTTPRPTTTP----------STSRPTTTTPRSTTTTSTSRPTTTTPRSTTTTT--- 407
             :.|:..||     ||.:|          ::||..|:|.....|.|...|.||...:|:..|   
Human 10915 EEASSAIPT-----PTVSPGVPGVVTSLVTSSRAVTSTTIPILTFSLGEPETTPSMATSHGTEAG 10974

  Fly   408 ----TRRP------TTTTPRSTTTTSTSRPTTTTPRSTTTTTTSRPTTTTPRSTTTTCTCSP--- 459
                |..|      |:....|...|||:.||.|.......||.|..|:....:::|..|.||   
Human 10975 SAVPTVLPEVPGMVTSLVASSRAVTSTTLPTLTLSPGEPETTPSMATSHGAEASSTVPTVSPEVP 11039

  Fly   460 ---TTTTPRSTTTTSTSRPT--------TTTPRSTTTTSTSGPTTTTPRSTTTTTTSG---PTTT 510
               |:....|:...|||.||        .||| |..|:..:..::..|..|.:...||   |..|
Human 11040 GVVTSLVTSSSGVNSTSIPTLILSPGELETTP-SMATSHGAEASSAVPTPTVSPGVSGVVTPLVT 11103

  Fly   511 TPRSTTTTCTCSPTTTTPRSTTTPSTSRPTTTTPRSTTTTCTCSP------TTTTPRSTTTTSTS 569
            :.|:.|:|.....|.::....||||.:  |:....:::...|.||      |:....|...|||:
Human 11104 SSRAVTSTTIPILTLSSSEPETTPSMA--TSHGVEASSAVLTVSPEVPGMVTSLVTSSRAVTSTT 11166

  Fly   570 RPTTTTPRSTTTTTTSRPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSG 634
            .||.|.......||||..|.:..:..:...|...:.|.....|:..||..:.|:..|..|.::|.
Human 11167 IPTLTISSDEPETTTSLVTHSEAKMISAIPTLAVSPTVQGLVTSLVTSSGSETSAFSNLTVASSQ 11231

  Fly   635 PTT---------TTPRS---TTTTSTSGPTT-------------TTPRSTTTTS-----TSGPTT 669
            |.|         |...|   |.|.||..|.|             |.||:|:..|     |...|.
Human 11232 PETIDSWVAHPGTEASSVVPTLTVSTGEPFTNISLVTHPAESSSTLPRTTSRFSHSELDTMPSTV 11296

  Fly   670 TTPRSTTTTSTSGPTTTTPR----STTTTSTSG-------PT----------------------T 701
            |:|.:.::::.|  ||.:|.    .|:..::||       ||                      |
Human 11297 TSPEAESSSAIS--TTISPGIPGVLTSLVTSSGRDISATFPTVPESPHESEATASWVTHPAVTST 11359

  Fly   702 TTPRSTTTTSTSGPTTTTPRSTT--TTSTSG-PTTT----TPRSTTTTSTSGPTTTTPRSTTTTS 759
            |.||:|...|.|.|.||...:|:  ..:||. ||.|    .|...|:..||..|.|:....|.|.
Human 11360 TVPRTTPNYSHSEPDTTPSIATSPGAEATSDFPTITVSPDVPDMVTSQVTSSGTDTSITIPTLTL 11424

  Fly   760 TSG-PTTTTPRST-TTTSTSGPTTTTPRS-------TTTTSTSGPTTTTPRSTTTTSTSGPTTT- 814
            :|| |.|||...| :.|.||....|.|.|       |:...:||..:||...|.|.:...|.|| 
Human 11425 SSGEPETTTSFITYSETHTSSAIPTLPVSPGASKMLTSLVISSGTDSTTTFPTLTETPYEPETTA 11489

  Fly   815 ------------TPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTS---TSGPTTTTP 864
                        .||:|...|.|...||.|.:.|   :.||..::..||||.|   :...|:..|
Human 11490 IQLIHPAETNTMVPRTTPKFSHSKSDTTLPVAIT---SPGPEASSAVSTTTISPDMSDLVTSLVP 11551

  Fly   865 RSTTTTSTSGPT-TTTPRSTTTTST----SGPTTTTPRSTTTTSTSGPTTTTPRSTTT----TST 920
            .|.|.|||:.|| :.||....||:|    ...|:||...|....:...:.|.|...|:    |.:
Human 11552 SSGTDTSTTFPTLSETPYEPETTATWLTHPAETSTTVSGTIPNFSHRGSDTAPSMVTSPGVDTRS 11616

  Fly   921 SCPTTTTPRSTTTTCTSGPTTTTPRSTTTTCTSCPTTT----TPRSTTTTCT--------SCPTT 973
            ..||||.|.|.....||..|:    |.|.|.|:.||.|    .|.:|.::.|        :.|..
Human 11617 GVPTTTIPPSIPGVVTSQVTS----SATDTSTAIPTLTPSPGEPETTASSATHPGTQTGFTVPIR 11677

  Fly   974 TTPRSTTTT----CTSGPTTTTP--RSTTKTSTCAPTTTTPRST---TTTSTSRPTTTTPRS--- 1026
            |.|.|...|    .|..|.|:||  |:|:..|..:|..|...:|   |..|::..||.:|.:   
Human 11678 TVPSSEPDTMASWVTHPPQTSTPVSRTTSSFSHSSPDATPVMATSPRTEASSAVLTTISPGAPEM 11742

  Fly  1027 -TTTTTTSRPTTTTPRSTTTPSTSRPTTTTPRST---TTTSTSRPTTT------------TPRST 1075
             |:..|:|...|:|...|.|.|...|.||...||   |.||.:.|.:|            |.|..
Human 11743 VTSQITSSGAATSTTVPTLTHSPGMPETTALLSTHPRTETSKTFPASTVFPQVSETTASLTIRPG 11807

  Fly  1076 TKTSTCAPTTTTPRSTT--TTTTSR----PTT-------TTPRST---TTTTTSRPTTT------ 1118
            .:|||..||.||....|  .|.|||    ||.       |.|.||   |.|:|..||:|      
Human 11808 AETSTALPTQTTSSLFTLLVTGTSRVDLSPTASPGVSAKTAPLSTHPGTETSTMIPTSTLSLGLL 11872

  Fly  1119 -------TPRSTTTPCTSRPTTTTPR----STTTTTTSRPTTTTPRST-TTPCPTTT--PSASPT 1169
                   |..|..|..::...|.:|.    |:.:.||.:|.|.|..:| |:|..|:.  |..|.|
Human 11873 ETTGLLATSSSAETSTSTLTLTVSPAVSGLSSASITTDKPQTVTSWNTETSPSVTSVGPPEFSRT 11937

  Fly  1170 RTTTTRRPCPCH-PQPP 1185
            .|.||....|.. |.||
Human 11938 VTGTTMTLIPSEMPTPP 11954

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sgs1NP_523475.3 None
MUC16NP_078966.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..138
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..180
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..229
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..287
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 396..554
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..674
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 695..719
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 740..888
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 949..981
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1082..1101
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1121..1149
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1301..1378
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1593..1641
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1704..1757
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1846..1930
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2010..2033
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2064..2140
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2153..2177
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2393..2455
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2566..2591
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2789..2822
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2838..2885
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2901..3006
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3019..3052
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3083..3148
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3172..3235
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3251..3276
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3299..3392
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3415..3436
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3462..3491
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3538..3588
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3644..3672
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3794..3829
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3843..3879
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3914..3982
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4024..4056
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4094..4121
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4138..4166
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4728..4748
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4845..4961
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5026..5066
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5128..5149
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5221..5249
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5271..5303
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5328..5365
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5381..5400
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5426..5507
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5519..5538
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5624..5654
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5675..5696
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5727..5747
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 5882..5931
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6054..6078
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6122..6149
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6219..6251
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6399..6425
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6438..6459
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6497..6545
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6682..6714
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6800..6822
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6845..6865
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6886..6939
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 6981..7004
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7028..7107
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7143..7208
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7279..7302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7320..7345
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7360..7427
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7437..7456
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7463..7503
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7527..7553
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7577..7597
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7726..7782
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7825..7849
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7908..7927
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7970..8000
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 8042..8078
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 8111..8134
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 8312..8331
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 8342..8389
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 8411..8472
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 8604..8624
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 8674..8741
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 8775..8880
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 8995..9018
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 9147..9168
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 9294..9460
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 9611..9635
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 9726..9753
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 9771..9791
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 9869..9890
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 10175..10218
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 10445..10469 7/26 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 10544..10590 11/45 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 10689..10719 3/29 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 10849..10872 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 10898..10926 9/32 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11003..11036 9/32 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11072..11092 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11269..11301 9/31 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11358..11400 16/41 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11508..11537 10/31 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11583..11724 43/144 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11836..11861 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 11913..11937 8/23 (35%)
12 X approximate tandem repeats. /evidence=ECO:0000269|PubMed:11786729 12067..13939
SEA 12074..12171 CDD:279699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 12196..12226
SEA 12231..12327 CDD:279699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 12353..12376
SEA 12388..12485 CDD:279699
SEA 12544..12641 CDD:279699
SEA 12699..12796 CDD:279699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 12819..12849
SEA 12855..12952 CDD:279699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 12978..13003
SEA 13011..13108 CDD:279699
SEA 13167..13264 CDD:279699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 13291..13317
SEA 13324..13420 CDD:279699
SEA 13479..13576 CDD:279699
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 13603..13625
SEA 13635..13732 CDD:279699
SEA 13793..13887 CDD:279699
SEA 13924..14021 CDD:279699
SEA 14075..14171 CDD:279699
SEA 14202..14281 CDD:279699
SEA 14321..14415 CDD:279699
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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