DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgs1 and MUC6

DIOPT Version :9

Sequence 1:	NP_523475.3	Gene:	Sgs1 / 33701	FlyBaseID:	FBgn0003372	Length:	1286	Species:	Drosophila melanogaster
Sequence 2:	NP_005952.2	Gene:	MUC6 / 4588	HGNCID:	7517	Length:	2439	Species:	Homo sapiens

Alignment Length:	1366	Identity:	430/1366 - (31%)
Similarity:	585/1366 - (42%)	Gaps:	289/1366 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 TGAECTCSDRTTASSTDSTTDRTTVTNTDWTTPL---------------------------CT-D 163
            :|.:|.|.....|:...:..|:...  .||.||.                           || .
Human  1094 SGGDCECLCDAVAAYAQACLDKGVC--VDWRTPAFCPIYCGFYNTHTQDGHGEYQYTQEANCTWH 1156

  Fly   164 TPPCTCSEESSTAIPSS----------------------PCIDTSTVIPTSPCTQETTTP-TPTC 205
            ..||.|..:.. ::|.|                      ||:.     ||:|  |..||| .||.
Human  1157 YQPCLCPSQPQ-SVPGSNIEGCYNCSQDEYFDHEEGVCVPCMP-----PTTP--QPPTTPQLPTT 1213

  Fly   206 STQGTQTTPCTCAQTTT--------------TPRSTT-------TTSTSRPTTTT---PRSTTTT 246
            .::.||..|.|...||.              ||.|.|       |.::|:||.::   ||.||..
Human  1214 GSRPTQVWPMTGTSTTIGLLSSTGPSPSSNHTPASPTQTPLLPATLTSSKPTASSGEPPRPTTAV 1278

  Fly   247 TTSRPTTTTPRSTTTTTTRRPTTTTPRCTTTTSTCAP-TTTTPRSTTTTTTSRPTTTTPRCTTTT 310
            |....:...|.:|..:|..:||.|......|.||.:| ||:|.:|||.||.:.||..|.. |:.|
Human  1279 TPQATSGLPPTATLRSTATKPTVTQATTRATASTASPATTSTAQSTTRTTMTLPTPATSG-TSPT 1342

  Fly   311 STCSPTRTTPRSTTTTSTS-RPTTTTPRCTTTPSTSRPTTTTPRSTTKTSTCAPTTTTPRPTTTP 374
            ...|..:..|.:|.|.:|. |||..:....|||...:||..|...||:|.|....||...|.||.
Human  1343 LPKSTNQELPGTTATQTTGPRPTPASTTGPTTPQPGQPTRPTATETTQTRTTTEYTTPQTPHTTH 1407

  Fly   375 STSRPTTTTPRSTTTTSTSRPTTTTPRSTTTTTTRRPTTTTPRSTTTTSTSRPTTTTP----RST 435
            |.....:..|.:...|:||...|||..:.:...|..||...|.||:..:.|..|..||    .:|
Human  1408 SPPTAGSPVPSTGPVTATSFHATTTYPTPSHPETTLPTHVPPFSTSLVTPSTHTVITPTHAQMAT 1472

  Fly   436 TTTTTSRPTTTTPRSTTTTCTCSPTTTTPRSTTTTSTSR-----PTTTTPRS--TTTTSTSGPTT 493
            :.:..|.||.|.|..||...|.|..|..|.:.||:.||:     .|..||.|  :.|:||..| .
Human  1473 SASNHSAPTGTIPPPTTLKATGSTHTAPPITPTTSGTSQAHSSFSTNKTPTSLHSHTSSTHHP-E 1536

  Fly   494 TTPRSTTTTTTSGPTTT---TPRSTTTTCTCS-----------PTTTTPRSTTTP--STSRPTTT 542
            .||.||||.|.: ||:|   ||.:.|.:.|.|           ||.::|.|:|.|  :||..|||
Human  1537 VTPTSTTTITPN-PTSTRTRTPVAHTNSATSSRPPPPFTTHSPPTGSSPFSSTGPMTATSFKTTT 1600

  Fly   543 TPRSTTTTCTCSPTTTTPRSTTTTSTSRPTTTTP----RSTTTTTTSRPTTTTPRSTTTTSTSGP 603
            |..:.:...|..||...|.||:..:.|..|..||    .:|:.:..|.||.|.|..||..:| |.
Human  1601 TYPTPSHPQTTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKAT-GS 1664

  Fly   604 TTTTPRSTTTTS-TSGPTTTTPRSTTTTSTSGPTTTT----PRSTTTTS-TSGPTTT-TPRSTTT 661
            |.|.|..|.||| ||...::...:.|:||....|::|    ..||:||: |..||:| ||..|.|
Human  1665 THTAPTMTLTTSGTSQALSSLNTAKTSTSLHSHTSSTHHAEATSTSTTNITPNPTSTGTPPMTVT 1729

  Fly   662 TS-TSGPTTTTPRSTTTTSTSGPTTTT--PRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRST 723
            || ||...::...:.|:||....|::|  |..|:|::||    .||..|:|      .|.||.:.
Human  1730 TSGTSQSRSSFSTAKTSTSLHSHTSSTHHPEVTSTSTTS----ITPNHTST------GTRTPVAH 1784

  Fly   724 TTTSTSG----PTTT--TPRSTTTTSTSGPTTTTPRSTTTT--STSGPTTTTPRSTTTTSTSGPT 780
            ||::||.    |.||  .|..||..|::||.|.|...||||  :.|.|.||.|....:.|||..|
Human  1785 TTSATSSRLPTPFTTHSPPTGTTPISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPSFSTSLVT 1849

  Fly   781 ---------TTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPR--S 834
                     |.|..:|:.:..|.||.|.|..||..:| |.|.|.|..|.|||   .|:.:|.  |
Human  1850 PSTHTVIIPTHTQMATSASIHSMPTGTIPPPTTIKAT-GSTHTAPPMTPTTS---GTSQSPSSFS 1910

  Fly   835 TTTTSTSGPTTT--------TPRSTTT-----TSTSGPTTTTPRSTTTTSTSG----PTTT--TP 880
            |..||||.|..|        ||.|||.     |||.   |.||.:.||:::|.    |.||  .|
Human  1911 TAKTSTSLPYHTSSTHHPEVTPTSTTNITPKHTSTG---TRTPVAHTTSASSSRLPTPFTTHSPP 1972

  Fly   881 RSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSCPTTTTPRSTTTTCTSGPTTTTPR 945
            ..::..|::||.|.|...||||.   ||.:.|:  ||..|..|..:|...|.:|.|...||.|..
Human  1973 TGSSPFSSTGPMTATSFQTTTTY---PTPSHPQ--TTLPTHVPPFSTSLVTPSTHTVIITTHTQM 2032

  Fly   946 STTTTCTSCPTTTTPRSTTTTCTSCPTTTTPRSTTTTCTSGPTTTTPRSTTKTSTCAPTTTTPRS 1010
            :|:.:..|.||.|.|..||...|....|..|.:.||:.||...::...:|..:|..:.::..|::
Human  2033 ATSASIHSTPTGTVPPPTTLKATGSTHTAPPMTVTTSGTSQTHSSFSTATASSSFISSSSWLPQN 2097

  Fly  1011 TTTTSTSRPTT---------TTPRSTT-------TTTTSRPTTTT---PRSTTTPSTSRPTTTT- 1055
            :::...|.|.|         |||.|||       :.:.|.|:|.:   |.|.::|.||.|:..|
Human  2098 SSSRPPSSPITTQLPHLSSATTPVSTTNQLSSSFSPSPSAPSTVSSYVPSSHSSPQTSSPSVGTS 2162

  Fly  1056 ------PRSTTTTSTSRPTTTTPRSTTKTSTCAP-------TTTTPRSTTTTTTSRPTTTT---P 1104
                  |..:||.|:...::.:...||.:.:.:|       .:||.|:|...|.|.|.|.:   |
Human  2163 SSFVSAPVHSTTLSSGSHSSLSTHPTTASVSASPLFPSSPAASTTIRATLPHTISSPFTLSALLP 2227

  Fly  1105 RSTTT---TTTSRPTTTTPRSTTTPCTSRPTTTTPRSTTTTTTSRPTTTTPR----------STT 1156
            .||.|   |.:|...::|....:||.|:..|.|.|..::.:||||.|:.|.|          |..
Human  2228 ISTVTVSPTPSSHLASSTIAFPSTPRTTASTHTAPAFSSQSTTSRSTSLTTRVPTSGFVSLTSGV 2292

  Fly  1157 TPCPTTTPSASPTRTTTTRRPCP--------------CHPQPPYQIPPWSWWYPNPTYPN--PVW 1205
            |..||     ||....|||.|.|              .|...|...|..|...|.||.|.  .|.
Human  2293 TGIPT-----SPVTNLTTRHPGPTLSPTTRFLTSSLTAHGSTPASAPVSSLGTPTPTSPGVCSVR 2352

  Fly  1206 PWQPN-------------------------PVVPQWPQMPGYPNQWPQLPGYPQQLPPPLPSPQW 1245
            ..|..                         .::.|  |:....:....|..|.|||..|.|.|..
Human  2353 EQQEEITFKGCMANVTVTRCEGACISAASFNIITQ--QVDARCSCCRPLHSYEQQLELPCPDPST 2415

  Fly  1246 P 1246
            |
Human  2416 P 2416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgs1	NP_523475.3	None
MUC6	NP_005952.2	VWD	40..192	CDD:214566
		C8	228..297	CDD:285899
		TIL	302..357	CDD:280072
		VWC_out	359..>403	CDD:214565
		VWD	386..549	CDD:214566
		C8	588..660	CDD:285899
		TIL	664..721	CDD:280072
		TIL	782..827	CDD:280072
		VWC	829..886	CDD:302663
		VWD	868..1017	CDD:278521
		C8	1057..1127	CDD:285899	9/34 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1455		86/255 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1471..1626		57/156 (37%)
		1, truncated	1561..1738		65/177 (37%)
		Approximate repeats	1607..1953		135/363 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1642..1834		77/202 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1868..1983		45/121 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2033..2077		15/43 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2090..2196		26/105 (25%)
		PHA03255	2188..>2343	CDD:165513	47/159 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2233..2278		14/44 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2348		8/24 (33%)
		CT	2351..2434	CDD:214482	13/68 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000