DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgs1 and dpy-6

DIOPT Version :9

Sequence 1:	NP_523475.3	Gene:	Sgs1 / 33701	FlyBaseID:	FBgn0003372	Length:	1286	Species:	Drosophila melanogaster
Sequence 2:	NP_509435.2	Gene:	dpy-6 / 181099	WormBaseID:	WBGene00001068	Length:	1254	Species:	Caenorhabditis elegans

Alignment Length:	1102	Identity:	345/1102 - (31%)
Similarity:	464/1102 - (42%)	Gaps:	187/1102 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 CTCSEESSTAIPSSPCIDTSTVIPTSPCTQETTTPT----PTCSTQGTQTTPCTCAQTTTTPRS- 226
            ||||.:.....||:| .|.||.|.:.........|:    ||.|:...:.......||..:..:
Worm    47 CTCSCKCVPDAPSNP-FDVSTTISSINNDNVDIGPSGDSNPTGSSWFQEIEATVGGQTVKSEHNI 110

  Fly   227 -TTTTSTSRPTTTTPRSTTTTTTSRPTTTTPRSTT---TTTTRRPTTTTPRCTTTTSTCAPTT-- 285
             ::.....:.||:|..|||...|:...:|||...|   ...::..:.|....|..::|.:|||
Worm   111 DSSVEVEKKVTTSTDASTTNAPTTGKDSTTPEIITGIVVINSKSESVTDMSTTRFSTTLSPTTEL 175

  Fly   286 -TTPRSTTTTTTSRPTTTTPRCTTTTSTCSPTRTT----PRSTTTTSTSRPTTTTPRCTTTPSTS 345
             |:|.:..:|.:|          |:|...||..||    |..|.||:.:..|:..|..:|..|..
Worm   176 LTSPETLVSTDSS----------TSTEQTSPDNTTEIASPMETNTTTEATTTSVEPSVSTLASED 230

  Fly   346 RPTTTTPRSTTKTSTCAPTTTTPRPTTTPSTSRPTTTTPRSTT--TTSTSRPTTTTPRSTTTTTT 408
            ..|.|....:|.|.....:|||..||||..     :||.:|||  ..:|..||.||....|||..
Worm   231 ETTVTAIAESTTTVIAEVSTTTEEPTTTAE-----STTKKSTTKAPATTEEPTPTTTEEVTTTEA 290

  Fly   409 RRPTTTTPRSTTTTSTSRPTTTTPRSTTTTTTSRPTTTTPRSTTTTCTCSPTT-TTPRSTTTTST 472
            ...|||    ::.|||.:|||    .......:.|.|..|.:|.     .|.| |||...|.|.|
Worm   291 ETSTTT----SSETSTEKPTT----PLIDNKIAGPATGKPETTH-----FPVTGTTPNFDTATET 342

  Fly   473 SRPTTTTPRSTTTTSTSGPTTTTPRSTTTTTTSGPTTTTPRSTTTTCTCSPTTTTPRSTTTPSTS 537
              |.........|.|.:..|.||.:  ||..|.||...|.::.:...   |.||.|...||.:||
Worm   343 --PFVAKSEDKMTLSKTAATETTQQ--TTEVTDGPEKETTKNVSIEI---PITTVPLVETTSTTS 400

  Fly   538 RPTTTTPRSTTTTCTCSPTTTTPRSTTTTSTSRPTTTTPRSTTTTTTSRPTTTTPRSTTTTSTSG 602
               |.:..|.....|.....||..|.:|.|.   ||..|.:..|||.|.   ..|:.|    ..|
Worm   401 ---TASKESDGFHTTLKLKVTTADSDSTESA---TTVKPFNEETTTKSH---VVPKPT----KKG 452

  Fly   603 PTTTTPR-----STTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSG--PTTTTPRSTT 660
            ....||:     ...|..|..|....||.||||:||..|||.....|..||:.  |||:...|||
Worm   453 TVKVTPKLELSFDEPTEITKAPHPVKPRKTTTTTTSTTTTTEKPVITEGSTTNKQPTTSEHESTT 517

  Fly   661 --TTSTSGPTTTTPRSTT--TTSTSGPTTTTPRSTTTTSTSGPTTTTPRST-TTTSTSGPTTTTP 720
              .|:|..|||||.:..|  ..:|..||||...|||...|   ||..|.:| ...:|..||||..
Worm   518 EVPTTTEEPTTTTGQHKTEKAITTEEPTTTEESSTTEEVT---TTEEPANTGNPPTTENPTTTEQ 579

  Fly   721 RSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTTSTSGPTTTTPR 785
            .::|..||   ||..|.:|..|.|:...||..:||.|..    .|||..|.:|..||    ||.:
Worm   580 PTSTAEST---TTALPFTTEQTVTTEEPTTAEKSTATQK----PTTTQESVSTEKTS----TTKK 633

  Fly   786 STTT---TSTSGPTTTTPRSTTTTSTSGPTTTTPRSTTTT----STSGPTTTTPRSTT---TTST 840
            ::||   |:|..|||||..|||..:|:...:||...||||    :|.|.|||...:||   ..::
Worm   634 ASTTEEPTTTDEPTTTTESSTTGKATTPELSTTSEETTTTELKITTEGSTTTEEPTTTAIFAEAS 698

  Fly   841 SGPTTTTPRSTTTTSTSGPTTTTPR-----STTTTSTSGPTTTTPR------------------- 881
            :|..||...:|:||||:...|:|..     :.|.||.|...::|||
Worm   699 TGIITTDEETTSTTSTTPEITSTKEIVTESAITQTSVSVVESSTPRQLPERWKAIVNKFKHNLEV 763

  Fly   882 ------------STTTTSTSGPTTTTP-----RSTTTTSTSGPTTTTPRSTTTTSTSCPTTTTPR 929
                        ||:||.:....|||.     ...|||.......|||.:|..::|...||||
Worm   764 LKEKKRLLKEKESTSTTGSDSSETTTVVAENIDEVTTTEKEKVVQTTPITTEKSTTQEETTTT-- 826

  Fly   930 STTTTCTSGPTTTTPRSTTTTCTSCPTTTTPRSTTTTCTSCPTTTTPRSTTTTCTSGPTTTTPRS 994
                      ||||.::|:.|.|..| ||:..:||.|.||.|:||   .:||..||..|
Worm   827 ----------TTTTEKTTSKTTTEKP-TTSESATTETTTSEPSTT---ESTTVDTSSAT------ 871

  Fly   995 TTKTSTCAPTTTTPRSTTTTSTSRP----TTTTPRSTTTTTTSRPTTTTPRSTTTPSTSR----- 1050
            |.::||.|.||||...|:.|:||..    |..:|.:|...::|:.:.....|...|...|
Worm   872 TEESSTAAETTTTSAETSETTTSESAAFITGESPENTALQSSSQKSEENESSAEKPGARRDFVPK 936

  Fly  1051 --PTTTTPRSTTTTSTSRPTTTTPRSTTKTSTCAPTTTTPRSTTTTTTSRPTTTTPRSTTTTTTS 1113
              .||..|..||:...:..|||.|.:||:.||...||.. .:||....:.|...|......||.:
Worm   937 KHKTTVKPAETTSAVAASTTTTEPITTTEKSTTLETTPI-EATTLNEVTGPAFVTGAPVDETTIN 1000

  Fly  1114 RPTTTTPRSTTTPCTSRPTTTTPRSTTTTT--------TSRPTTTTPRSTTTPCPTTTPSAS 1167
            .....:..:.|.....:||..:.....::.        |..|...|..:||.....|...||
Worm  1001 TLELLSKINNTQISQPKPTDISKTDALSSLISGLIGSFTKAPMAPTIHTTTDAAFVTATEAS 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
Sgs1	NP_523475.3	None
dpy-6	NP_509435.2	GBP_C	<1089..1182	CDD:303769
dpy-6	NP_509435.2	coiled coil	1157..1166	CDD:293879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000