Protein Alignment hoe2 and PHO90

DIOPT Version :10

• Sequence 1: NP_608878.1
• Gene: hoe2 / 33700
• FlyBaseID: FBgn0031649
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_012337.1
• Gene: PHO90 / 853241
• SGDID: S000003734
• Length: 881
• Species: Saccharomyces cerevisiae
• Alignment Length: 970
• Identity: 178/970 - (18%)
• Similarity: 342/970 - (35%)
• Gaps: 308/970 - (31%)

  Fly    14 SPGREKSSGIELQQRSPRGACHHNQVAAVQVTEQSLQVWRALPAEIRHDPSMASFQMENERI--- 75
            |.|..|.:||                     .|::::: |.||.........:.|:...|:|
Yeast    72 SSGMNKDAGI---------------------VEETIEL-RELPTAQTVAAKPSPFRRMKEKIFYK 114

  Fly    76 ----HGSSGGATDDED--------------------EDGYEEV-------------DMKNVSRIQ 103
                ..||..:|.:|:                    :|.|:..             |:|.:..|:
Yeast   115 RRSSSASSVSSTANENLQLDTYDTFVGDLTAEKQKVDDFYKRTEAKFYDKFDALVKDLKKIGVIE 179

  Fly   104 ---------DEPGSSFAGSDF--LDIKNRPGDENATDDEVTTHSDHEAANGGPGNAKSQARRIHH 157
                     :||.:| ...:.  ||:.:...|:...||:              .|.:.....:||
Yeast   180 YDIDDDTLFNEPIAS-TNDEVPPLDLDDDEDDDEFYDDQ--------------SNIEDNTALLHH 229

  Fly   158 KSKRSKEQRQRDKLWKRGGLLVF----WILSAVVLISVGEKHLLEKTIDV-------PMGEEGKF 211
            .....|.|::  .|.|:..:.::    .:.|.:.|..:|...:.:|:..|       .:.|..:|
Yeast   230 SQYNIKSQKK--SLLKKSIVNLYIDLCQLKSFIELNRIGFAKITKKSDKVLHLNTRTELIESEQF 292

  Fly   212 FK---LLQKPTGDFRLKIHGAFRELSTL-----DAPENETLSFGFLTVQPQVSTYIGENHSQVFQ 268
            ||   ..|..|.:.   ::....:|.|.     |.|.|.:.|      :.::.:|:   |..:..
Yeast   293 FKDTYAFQAETIEL---LNSKISQLVTFYARITDRPHNISHS------KQELKSYL---HDHIVW 345

  Fly   269 DILPAWR--LPLLSE-EELMLRAPAVTTNRTYQMTQELDEMLAGKNSEFRLHIYSDVEVDLAIVL 330
            :....|:  |.|||: :||..:......|:           |.||             :||....
Yeast   346 ERSNTWKDMLGLLSQADELTPKETEYNANK-----------LVGK-------------LDLEYYR 386

  Fly   331 NYNPLIVNARTGSILAGVILLIFYALLVWELFERTFVAMICSILSVTTLACFNDRPN-------- 387
            ...|..:|.:..||....:..:|:....::::   |:.::..:|  ..:..|||...
Yeast   387 WPLPRPINLKFTSINNVALPKLFFTKKAYKIY---FIILVTGLL--LGIKTFNDAAQHRCMALVE 446

  Fly   388 -------------------------MDEIIQWMD----------MELLTLLFCMMLLIL------ 411
                                     :.::::..|          .|:|..::...::||
Yeast   447 CVAFLWASEAIPLHITAFLVPLLVVLFKVLKTSDGAIMSAASASSEILAAMWSSTIMILLAGFTL 511

  Fly   412 --ILTETGVFDYLAVFCFEISGGKIWP---MIYSLCLVTCL---VSSVLDNMTTVLLLTPVAIRL 468
              :|.:..:...||.:....:|.|  |   ::.::|:|..|   :|:|...:.|..||:|    |
Yeast   512 GEVLAQYNIAKVLASWLLAFAGCK--PRNVLLMAMCVVFFLSMWISNVAAPVLTYSLLSP----L 570

  Fly   469 CEVMQLD-PL--PVVMGIIVHANIGGALTPIGDPISIIVSTNHFIVDNDVTFPTFVAHTFPGVIL 530
            .:.|..| |.  .:|:|:.:.|||||..:||..|.:||  :..::....:.:..|.|...|..||
Yeast   571 LDAMDADSPFAQALVLGVALAANIGGMSSPISSPQNII--SMSYLKPYGIGWGQFFAVALPSGIL 633

  Fly   531 AVIQSCVYLRLFYHNIDALRLNEPKEMSELRREMKVWQRALNAVASCSKDAQLVRGTLQAKIKQL 595
            |::  .|::.||    ...::|:.|
Yeast   634 AML--LVWILLF----TTFKMNKTK---------------------------------------- 652

  Fly   596 KRTLRRLQKGVGSTEVYTNTLDELKQKYPIKNKTLLLQSAGALLFVIVCFFIQSVPHWRTLPLGW 660
                  |:|           ...:|.|:.:|...::..:...:|.    :.::|.........|.
Yeast   653 ------LEK-----------FKPIKTKFTVKQYYIITVTVATILL----WCVESQIEGAFGSSGQ 696

  Fly   661 VALLGVILLL--IILNRDDMEHLMHRIEWTTLLFFAAMFVMMECVERLGIFACISELTEHVILSV 723
            :|::.::|..  .:|:..|    ::...|:.::.......:.:.|...|:.:.|::..:..|.:.
Yeast   697 IAIIPIVLFFGTGLLSTQD----LNAFPWSIVILAMGGIALGKAVSSSGLLSTIAKALQKKIEND 757

  Fly   724 GKSHRLAMAIFMILWMSALASSILDSIPVAA-IMVKLVTSLVAKPSLGLPLQP--LVWALTLGAS 785
            |     ..||..|..:..|......|..|:| |::.||..:..|  ||.|...  ||:...|.:|
Yeast   758 G-----VFAILCIFGILMLVVGTFVSHTVSAIIIIPLVQEVGDK--LGNPKAAPILVFGCALLSS 815

  Fly   786 MGGNGTLYGASANVIAAGIAEQHGYK-LSFTRYL-RTVFPMMLGQITLMTV-YLLVAHVV 842
            . |.|.......||.|....::.|.: ||...:| |.|...:|..:.::|: |.::|.||
Yeast   816 C-GMGLASSGFPNVTAISKVDRKGDRYLSVMTFLTRGVPASILAFLCVITLGYGIMASVV 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hoe2	NP_608878.1	P_permease	350..837	CDD:238536	103/554 (19%)
PHO90	NP_012337.1	COG5408	1..288	CDD:227695	41/254 (16%)
		SLC13_permease	442..870	CDD:238535	97/514 (19%)