DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hoe2 and oca2

DIOPT Version :9

Sequence 1:	NP_608878.1	Gene:	hoe2 / 33700	FlyBaseID:	FBgn0031649	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_695807.5	Gene:	oca2 / 567419	ZFINID:	ZDB-GENE-070718-4	Length:	834	Species:	Danio rerio

Alignment Length:	894	Identity:	281/894 - (31%)
Similarity:	456/894 - (51%)	Gaps:	129/894 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EKSSGIELQQRSPRGACHHNQV---------------------AAVQVTEQSLQVWRALPA---- 57
            |..|.||::.....|..|.::|                     :..:.|::.||. .|:|:
Zfish     4 ENKSNIEVEMSQTGGQGHSSRVGRRKSDSVSGNFDELRLLEGFSGKKETQKLLQA-AAMPSGHCI 67

  Fly    58 -------EIRHDPSMASFQMENERIHGSSGGATDDEDEDGYEEVDMKNVSRIQDEPGSSFAGSDF 115
                   |.||     ||.|.| .::|.|..|...|
Zfish    68 IYTDVHQEDRH-----SFNMVN-LLNGKSNQANHTE----------------------------- 97

  Fly   116 LDIKNRPGDENATDDEVTTHSDHEAANG-GPGNAKSQARRIHHKSKRSKEQRQRDKLWKRGGLLV 179
                ..|..:.:.:|.:|..:.||.:.| |..:.::.:..:..:.:...|......:........
Zfish    98 ----RTPLLKFSQNDSITYMTLHEPSLGSGEESWEASSAELERRCRLGSEVTSLSHITSPEKSEN 158

  Fly   180 FWILSAVVLISVGEKHLLEKTIDVPMGEEGKFFKLL---QKP---------------TGDFR--- 223
            ::.||..:...:|...|:  ||.|.:.....||.:.   :.|               ..|||
Zfish   159 YFKLSFPIRYCLGMTRLI--TIFVIVVLCSLFFSMYPDRESPWRMLAVSSTESFSMNLTDFRDNS 221

  Fly   224 ---LKIHGAFRELSTLDAPENETLSFGFLTVQPQVSTYIGENHSQVFQDILPAWRLPLLSEEELM 285
               |::.|.|  |..::|.:.   |..::.:|.:.:...|....:. |.:|..|.:||.|:
Zfish   222 LLKLQVGGPF--LGGMEAVQE---SQEYILIQVEQTEEAGPRRRRT-QQVLYNWTIPLHSQ---- 276

  Fly   286 LRAPAVTTNRTYQMTQELDEMLAGKNSEFRLHIYSDVEVDLAIVLNYNPLIVNARTGSILAGVIL 350
             |:..:...||::|.......::.:  .|.|    |.:| :.:.:....|.|...|..::||:||
Zfish   277 -RSDQILRTRTFEMVSSAPIQISVQ--AFLL----DNQV-VPLSMTNQSLYVTVETQVLIAGLIL 333

  Fly   351 LIFYALLVWELFERTFVAMICSILSVTTLACFNDRPNMDEIIQWMDMELLTLLFCMMLLILILTE 415
            ...|.|:::|:..||..||:.|:.::..||...|||::..:::|:|.|.|.|||.||:|:.|.:|
Zfish   334 AGVYVLIIFEIVHRTLAAMLGSLSALAALAFIGDRPSLMTVVEWIDYETLALLFGMMILVAIFSE 398

  Fly   416 TGVFDYLAVFCFEISGGKIWPMIYSLCLVTCLVSSVLDNMTTVLLLTPVAIRLCEVMQLDPLPVV 480
            ||.|||.||..:::|.|::||||..|||:..::|:.|||:||::|.|||.||||||:.|||..|:
Zfish   399 TGFFDYCAVKAYQLSRGRVWPMIIILCLIAAILSAFLDNVTTMMLFTPVTIRLCEVLNLDPRQVL 463

  Fly   481 MGIIVHANIGGALTPIGDPISIIVSTNHFIVDNDVTFPTFVAHTFPGVILAVIQSCVYLRLFYHN 545
            :..::..|||||.|.:|||.::|:.:|..:....:.|..|..:.|.|:.|.::.|..:|||.:.|
Zfish   464 IAEVIFTNIGGAATAVGDPPNVIIVSNQDLRKKGIDFAAFTGYMFLGICLVLLTSFPFLRLLFWN 528

  Fly   546 IDALRLNEPKEMSELRREMKVWQRALNAVASCSKDAQLVRGTLQAKIKQLKRTLRR----LQKGV 606
             ..|...|..|:.||:.|:.||::..:.:...|::...|:..|..|:..|:..||:    .|:.:
Zfish   529 -KKLYNKESSEIVELKHEILVWRQTAHRINPASREETAVKCLLMQKVLNLESLLRKKLKTFQRQI 592

  Fly   607 GSTEV-YTNTLDELKQKYPIKNKTLLLQSAGALLFVIVCFFIQS-VP--HWRTLPLGWVALLGVI 667
            ...:. :.:.:.||::|:.|.:|.||::....|..||..||:.| ||  |   |.|||:|:||.:
Zfish   593 SQEDKNWEHNIQELQKKHRITDKVLLVKCLTVLGVVIFMFFLNSFVPAIH---LDLGWIAILGAL 654

  Fly   668 LLLIILNRDDMEHLMHRIEWTTLLFFAAMFVMMECVERLGIFACISELTEHVILSVGKSHRLAMA 732
            .||::.:..|.|.::||:||.|||||||:||:||.:.:|.:...|.|.|..:|.:|.:..|||:|
Zfish   655 WLLVLADIQDFEIILHRVEWATLLFFAALFVLMEALAQLQLIDYIGEQTAVLIKAVPEDERLAIA 719

  Fly   733 IFMILWMSALASSILDSIPVAAIMVKLVTSLVAKPSLGLPLQPLVWALTLGASMGGNGTLYGASA 797
            |.::||:||||||::|:||..|.|:.::.:|.....:.||::||::||.:||.:||||||.||||
Zfish   720 IILVLWVSALASSLIDNIPFTATMIPVLINLSQDADVNLPIKPLIFALAMGACLGGNGTLIGASA 784

  Fly   798 NVIAAGIAEQHGYKLSFTRYLRTVFPMMLGQITLMTVYLLVAHVVFEWH 846
            ||:.|||||||||..||..:.|..|||||...|:...|||..|:...|:
Zfish   785 NVVCAGIAEQHGYGFSFMEFFRLGFPMMLMTCTIGMCYLLATHIGLHWN 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hoe2	NP_608878.1	ArsB	343..837	CDD:223983	208/501 (42%)
hoe2	NP_608878.1	P_permease	350..837	CDD:238536	205/494 (41%)
oca2	XP_695807.5	ArsB	324..826	CDD:223983	211/505 (42%)
oca2	XP_695807.5	P_permease	333..824	CDD:238536	205/494 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580420
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1172
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D150165at33208
OrthoFinder	1	1.000	-	-		FOG0001813
OrthoInspector	1	1.000	-	-		mtm6389
orthoMCL	1	0.900	-	-		OOG6_101594
Panther	1	1.100	-	-	O	PTHR43568
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2794
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.990