DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hoe2 and CG31693

DIOPT Version :9

Sequence 1:	NP_608878.1	Gene:	hoe2 / 33700	FlyBaseID:	FBgn0031649	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_724369.2	Gene:	CG31693 / 318887	FlyBaseID:	FBgn0051693	Length:	688	Species:	Drosophila melanogaster

Alignment Length:	724	Identity:	219/724 - (30%)
Similarity:	367/724 - (50%)	Gaps:	80/724 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 THSDHEAANGGPGNAKSQARRIHHKSKRSKEQRQRDKLWKRGGLLVFWILSAVVLISVGEKHLLE 198
            |.||....|.|..::....:.||              :.|...||:.|:..|.::.....:....
  Fly    29 TRSDIRRQNDGQQSSGRHVKIIH--------------IVKMCILLLLWLGCAFIVFVFAAEQSTR 79

  Fly   199 KTIDVPMGEEGKFFKLLQKPTGDFRLKIHGAFRELSTLDAPENETLSFGFLTVQPQVSTYIGENH 263
            .|:...|..:....| ::.|....::.:||..:.    :..:...|...:.:....| ||   ..
  Fly    80 STMITVMPNKTAMTK-VEPPNNALKVTLHGPVQS----NGADGVDLRLEWRSSDLNV-TY---RR 135

  Fly   264 SQVFQDILPAWRLPLLSEEELMLRAPAVTTNRTYQMT-----QELDEMLAGKNSEFRLHIYSDVE 323
            ::|       |.:.:.:::....:   |:.|...:.|     |.:..:.:.:||...||
  Fly   136 TEV-------WNIGISNDDTAYAK---VSRNFMVKRTGGADSQAVISLESKRNSPISLH------ 184

  Fly   324 VDLAIVLNYNPLIVNARTGSILAGVILLIFYALLVWELFERTFVAMICSILSVTTLACFNDRPNM 388
                :|::.||::.:...  :.||:::|..|.|:::::.:.||.|:|.:..:|..||....||:|
  Fly   185 ----VVIDTNPMVTDMCL--VCAGLLILGLYMLIIFDVIDHTFAALIIATTAVAILAILEHRPSM 243

  Fly   389 DEIIQWMDMELLTLLFCMMLLILILTETGVFDYLAVFCFEISGGKIWPMIYSLCLVTCLVSSVLD 453
            ..|:.:::.|.|.|||.:|.::.|:..|||||:|.|:.:.||.|:.||:|:.|.::|..:|:.|:
  Fly   244 RAIVSFVNFEPLMLLFGLMTIVDIMATTGVFDFLVVWTYRISRGRPWPLIFFLSMLTAFLSAFLN 308

  Fly   454 NMTTVLLLTPVAIRLCEVMQLDPLPVVMGIIVHANIGGALTPIGDPISIIVSTNHFIVDNDVTFP 518
            :....|.|||:.|||||.|.|....|::.:.:.|::||||||:|:|.:.||:|:...|...|.|.
  Fly   309 SDIMALSLTPITIRLCEEMSLRTSYVLVVMAIFADMGGALTPLGNPPNAIVTTSPVAVAEGVDFA 373

  Fly   519 TFVAHTFPGVILA--VIQSCVYLRLFYH--NIDALRLNEPKEMSELRREMK-VWQRALNAVASCS 578
            .|:.|..|||:.|  |:...:|:.   |  :|..|..|:...|.|..|..| ..|..|:.:|
  Fly   374 HFIIHMMPGVLAAMFVVFGIIYVT---HRKSIFVLDQNQLDLMEERARGKKPPSQETLDRIA--- 432

  Fly   579 KDAQLVRGTLQAKIKQLKRTLRRLQKGVGSTEVYTNTLDELKQKYPIKNKTLLLQSAGALLFVIV 643
                |::|:|..|.     .||       ..|.|..||.||:....|.:|.||::...||:|..:
  Fly   433 ----LLKGSLPGKY-----WLR-------PVEGYPETLAELEASSRILDKPLLVRCCIALIFAFL 481

  Fly   644 CFFIQSVPHWRT-LPLGWVALLGVILLLIILNRDDMEHLMHRIEWTTLLFFAAMFVMMECVERLG 707
            |..:.|:|.... ..||||.||...||:|:.:::|:...:..|:||.|||.||:||:.|.|::||
  Fly   482 CMLLHSIPKVADGASLGWVTLLAAFLLIILDDKNDLNATLGIIQWTILLFIAALFVLSEAVDQLG 546

  Fly   708 IFACISELTEHVILSVGKSHRLAMAIFMILWMSALASSILDSIPVAAIMVKLVTSLVAKPSLGLP 772
            .|..:.:.|...:.|:...:::|:...:|||.:||.:..:|:..|...|:|....:.:...  :|
  Fly   547 FFEWLGDRTVGFLRSLEPQNQIAVTTMVILWTTALLTIFIDNAAVTIFMLKFSIEMASNDD--IP 609

  Fly   773 LQPLVWALTLGASMGGNGTLYGASANVIAAGIAEQHGYKLSFTRYLRTVFPMMLGQITLMTVYLL 837
            |.|:.||||.||..||||:|:||.:|.|.|.||.|||||:||..:....||:||..:.:.:.|||
  Fly   610 LPPMFWALTFGACFGGNGSLFGAVSNEIIALIALQHGYKISFWHFFAIGFPLMLVTMVIGSGYLL 674

  Fly   838 VAHVVFEWH 846
            :||.|..|:
  Fly   675 IAHSVLSWN 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hoe2	NP_608878.1	ArsB	343..837	CDD:223983	178/499 (36%)
hoe2	NP_608878.1	P_permease	350..837	CDD:238536	176/492 (36%)
CG31693	NP_724369.2	ArsB	196..675	CDD:223983	179/504 (36%)
CG31693	NP_724369.2	P_permease	205..674	CDD:238536	176/492 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448691
Domainoid	1	1.000	108	1.000	Domainoid score	I2147
eggNOG	1	0.900	-	-		E1_COG1055
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	135	1.000	Inparanoid score	I1832
Isobase	1	0.950	-	0	Normalized mean entropy	S7077
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D150165at33208
OrthoFinder	1	1.000	-	-		FOG0001813
OrthoInspector	1	1.000	-	-		otm3389
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43568
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.850