DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hoe2 and oca2

DIOPT Version :9

Sequence 1:	NP_608878.1	Gene:	hoe2 / 33700	FlyBaseID:	FBgn0031649	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	XP_012813149.2	Gene:	oca2 / 100487559	XenbaseID:	XB-GENE-989255	Length:	858	Species:	Xenopus tropicalis

Alignment Length:	638	Identity:	240/638 - (37%)
Similarity:	371/638 - (58%)	Gaps:	33/638 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 DFR------LKIHGAFRELSTLDAPENETLSFGFLTVQPQVSTYIGENHSQVFQDILPAWRLPLL 279
            |||      |:|.|.|.. ..||...:|.:.......:..||.  ....|||..:    |.|||.
Frog   241 DFRNAALLKLQIDGPFAG-DLLDPRNDEYILVQITQTEDPVSR--RRRSSQVTYN----WTLPLS 298

  Fly   280 SEEELMLRAPAVTTNRTYQMTQELDEMLAGKNSEFRLHIYSDVEVDLAIVLNYNPLIVNARTGSI 344
            |.     |...:...:|:       |:|........:..:......:.:.|::..|..:..|...
Frog   299 SR-----RKEHIIREKTF-------EILDSDTISINIQAFLQGTQLVPLSLSHQYLSASIETQVT 351

  Fly   345 LAGVILLIFYALLVWELFERTFVAMICSILSVTTLACFNDRPNMDEIIQWMDMELLTLLFCMMLL 409
            :|.|:|...|.|:::|:..||..||:.|:.::..||...|||::.::::|:|.|.|.|||.||:|
Frog   352 IAAVVLAGVYVLIIFEIVHRTLAAMLGSLAALAALALVGDRPSLVKVVEWIDYETLALLFGMMIL 416

  Fly   410 ILILTETGVFDYLAVFCFEISGGKIWPMIYSLCLVTCLVSSVLDNMTTVLLLTPVAIRLCEVMQL 474
            :.:.::||.|||.||..:::|.|:|||||..|||:..::|:.|||:||:||.|||.||||||:.|
Frog   417 VAVFSDTGFFDYCAVKAYQLSRGRIWPMIIILCLIAAILSAFLDNVTTMLLFTPVTIRLCEVLNL 481

  Fly   475 DPLPVVMGIIVHANIGGALTPIGDPISIIVSTNHFIVDNDVTFPTFVAHTFPGVILAVIQSCVYL 539
            ||..|::..::..|||||.|.:|||.::|:.:|..:...::.|..|..|.|.|:.|.::.|..:|
Frog   482 DPRHVLIAEVIFTNIGGAATAVGDPPNVIIVSNQELRKVELDFAGFTGHMFLGICLVLLVSFPFL 546

  Fly   540 RLFYHNIDALRLNEPKEMSELRREMKVWQRALNAVASCSKDAQLVRGTLQAKIKQLKRTLRR--- 601
            |:.|.| ..|...||.|:.||:.|:.||:.....:...|::...|:..|..|:.:|:..||:
Frog   547 RILYWN-KKLYNKEPSEIVELKHEIHVWRLTAQRINPASREETAVKCLLMQKVLKLESLLRKKLQ 610

  Fly   602 -LQKGVGSTEV-YTNTLDELKQKYPIKNKTLLLQSAGALLFVIVCFFIQS-VPHWRTLPLGWVAL 663
             .|:.:...:. :...:.||::::.|.:|.||::....|.|||..||:.| ||... |.|||:|:
Frog   611 TFQRQISQEDKNWETNIQELQKRHGISDKILLIKCLSVLGFVIFMFFLNSFVPEIH-LDLGWIAI 674

  Fly   664 LGVILLLIILNRDDMEHLMHRIEWTTLLFFAAMFVMMECVERLGIFACISELTEHVILSVGKSHR 728
            ||.:.||::.:..|.|.::||:||.|||||||:||:||.:..|.:...|.|.|..:|.:|.:..|
Frog   675 LGSLWLLVLADVHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYIGEQTALLIKAVPEDER 739

  Fly   729 LAMAIFMILWMSALASSILDSIPVAAIMVKLVTSLVAKPSLGLPLQPLVWALTLGASMGGNGTLY 793
            ||:||.:::|:||||||::|:||..|.|:.::.:|.....:.||::||::||.:||.:||||||.
Frog   740 LAIAIILVVWVSALASSLIDNIPFTATMIPVLINLSQDADVNLPIKPLIFALAIGACLGGNGTLI 804

  Fly   794 GASANVIAAGIAEQHGYKLSFTRYLRTVFPMMLGQITLMTVYLLVAHVVFEWH 846
            ||||||:.|||||||||..||..:.|..||||:....:...||||||||..|:
Frog   805 GASANVVCAGIAEQHGYGFSFMEFFRLGFPMMIVSTAIGMCYLLVAHVVLGWN 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hoe2	NP_608878.1	ArsB	343..837	CDD:223983	205/499 (41%)
hoe2	NP_608878.1	P_permease	350..837	CDD:238536	203/492 (41%)
oca2	XP_012813149.2	P_permease	357..848	CDD:238536	203/492 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1181
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D150165at33208
OrthoFinder	1	1.000	-	-		FOG0001813
OrthoInspector	1	1.000	-	-		otm48523
Panther	1	1.100	-	-	O	PTHR43568
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2794
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070