DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3036 and SLC17A6

DIOPT Version :9

Sequence 1:	NP_001260058.1	Gene:	CG3036 / 33695	FlyBaseID:	FBgn0031645	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_065079.1	Gene:	SLC17A6 / 57084	HGNCID:	16703	Length:	582	Species:	Homo sapiens

Alignment Length:	485	Identity:	166/485 - (34%)
Similarity:	259/485 - (53%)	Gaps:	43/485 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GLQRVRNFLSCRQVLNLLTMLGFMLNYALRVNLTIAIVDMVRPNVTSAVNATLVGNSTAANSTAS 72
            ||.|       |.::.:::.|||.:::.:|.||.:||||||.                  |||..
Human    66 GLPR-------RYIIAIMSGLGFCISFGIRCNLGVAIVDMVN------------------NSTIH 105

  Fly    73 PDGVDVYEE-RFPWDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITP 136
            ..|..:.|: :|.||......:.|.||||||:|::|||.:|..:...||||.::|..|.|.::.|
Human   106 RGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIP 170

  Fly   137 LAAHINYVVLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERSKFMSNMMASS-LGAAITMPICGY 200
            .||.::|..:|.||::.|.:.|.::||.|.:.:.|.||:|||:..:.....| .||.|.||:.|.
Human   171 SAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGI 235

  Fly   201 LISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRISAEERREIEEAIGTTTS---KKRPSH 262
            |:...||:||||:.|:.|::|.:.|....||:||.||.|:.||||.|||:||.:.:   ......
Human   236 LVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFK 300

  Fly   263 VPWGQLLCSPAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVA 327
            .||.:...|..|:|||:.:....:.|:.::...|.:..::..|:|.:.|:.|::|:|...::...
Human   301 TPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPI 365

  Fly   328 SSYLADYLRKKGTLSTTATRKLFTTFALVIPGLLMIVQVFLGYDATWSVTI--FSLALFAHGAVT 390
            ...:||:||.|..||||..||:.......:...|::|   :||..|..|.|  ..||:...|...
Human   366 GGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLV---VGYSHTRGVAISFLVLAVGFSGFAI 427

  Fly   391 AGYLGNGLDIAPNFGGTIFGLANTLSSFGGFLSTSMVGALTYKDQSFHSWQIVFWILAATYISAA 455
            :|:..|.|||||.:...:.|::|.:.:..|.:...:|||:| |::|...||.||.|.|..:....
Human   428 SGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMT-KNKSREEWQYVFLIAALVHYGGV 491

  Fly   456 VVFAILGSGELQPWNNPPERVRISDVTQEE 485
            :.:||..|||.|||.:|.|       |.||
Human   492 IFYAIFASGEKQPWADPEE-------TSEE 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3036	NP_001260058.1	2A0114euk	19..477	CDD:129972	160/464 (34%)
CG3036	NP_001260058.1	MFS	83..461	CDD:119392	133/383 (35%)
SLC17A6	NP_065079.1	MFS_SLC17A6_7_8_VGluT	74..498	CDD:340940	151/445 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820