DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3036 and SLC17A8

DIOPT Version :9

Sequence 1:	NP_001260058.1	Gene:	CG3036 / 33695	FlyBaseID:	FBgn0031645	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	488	Identity:	156/488 - (31%)
Similarity:	254/488 - (52%)	Gaps:	39/488 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RQVLNLLTMLGFMLNYALRVNLTIAIVDMVRPNVTSAVNATLVGNSTAANSTASPDG-VDVYEER 82
            |.::.:::.|||.:::.:|.||.:|||:||.                  |||...|| .::...:
Human    75 RYIIAIMSGLGFCISFGIRCNLGVAIVEMVN------------------NSTVYVDGKPEIQTAQ 121

  Fly    83 FPWDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASLLTLITPLAAHINYVVLI 147
            |.||......:.|.||||||:|::|||.::......||||.::...|.|.:..|.||.::|..::
Human   122 FNWDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVM 186

  Fly   148 VVRVVLGFMLGASWPAIHPVAAVWIPPMERSKFMSNMMASS-LGAAITMPICGYLISVAGWASVF 211
            .||::.|.:.|.::||.|.:.:.|.||:|||:..:.....| .||.:.||:.|.|:...||:|||
Human   187 CVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSVF 251

  Fly   212 YLTGAVGLLWSLAWFTFVYETPATHPRISAEERREIEEAIG-----TTTSKKRPSHVPWGQLLCS 271
            |:.|..|::|.:.|....||.||.||.||.||:..||.:||     .:.||   ...||.:...|
Human   252 YIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSK---FSTPWKRFFTS 313

  Fly   272 PAVWAIIICHGLAVFGFFTVVNQLPTFMSKILHFDIKQNGLFSSLPYLGKYVMAVASSYLADYLR 336
            ..|:|||:.:....:.|:.::...|.:..::..|.|.:.||.|::|::...::......||||||
Human   314 LPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLR 378

  Fly   337 KKGTLSTTATRKLFTTFALVIPGLLMIVQVFLGYDATWSVTI--FSLALFAHGAVTAGYLGNGLD 399
            .:..|:|||.||:.......:...|::|   :|:..|..|.|  ..||:...|...:|:..|.||
Human   379 SRQILTTTAVRKIMNCGGFGMEATLLLV---VGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLD 440

  Fly   400 IAPNFGGTIFGLANTLSSFGGFLSTSMVGALTYKDQSFHSWQIVFWILAATYISAAVVFAILGSG 464
            |||.:...:.|::|.:.:..|.:...:|||:| :.::...||.||.|.|..:.|..:.:.:..||
Human   441 IAPRYASILMGISNGVGTLSGMVCPLIVGAMT-RHKTREEWQNVFLIAALVHYSGVIFYGVFASG 504

  Fly   465 ELQPWNNP----PERVRISDVTQ-EEGVPLKNE 492
            |.|.|.:|    .|:..|.|..: .|.:.|.:|
Human   505 EKQEWADPENLSEEKCGIIDQDELAEEIELNHE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3036	NP_001260058.1	2A0114euk	19..477	CDD:129972	151/470 (32%)
CG3036	NP_001260058.1	MFS	83..461	CDD:119392	127/385 (33%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		2A0114euk	75..513	CDD:129972	149/462 (32%)
		MFS	80..502	CDD:119392	143/446 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820