DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3036 and SLC17A2

DIOPT Version :9

Sequence 1:	NP_001260058.1	Gene:	CG3036 / 33695	FlyBaseID:	FBgn0031645	Length:	493	Species:	Drosophila melanogaster
Sequence 2:	NP_001273052.1	Gene:	SLC17A2 / 10246	HGNCID:	10930	Length:	478	Species:	Homo sapiens

Alignment Length:	484	Identity:	146/484 - (30%)
Similarity:	233/484 - (48%)	Gaps:	39/484 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TEKGGLQRVRNFLSCRQVLNLLTMLGFMLNYALRVNLTIAIVDMVRPNVTSAV-NATLVGNSTAA 67
            |.||     .:|.|.|..|.|:...........||:|:|||:.||.......: ||:..|....|
Human     7 TRKG-----PDFCSLRYGLALIMHFSNFTMITQRVSLSIAIIAMVNTTQQQGLSNASTEGPVADA 66

  Fly    68 --NSTASPDGVDVYEERFPWDSYQTNFVLGCFFWGYILTELPGGRLAELIGGRRVFGHSMLWASL 130
              ||:.|....|.....:.|.......:.....:|.|||.:|.|.||.:.|.:::.|..:|.:||
Human    67 FNNSSISIKEFDTKASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSL 131

  Fly   131 LTLITPLAAHINYVVLIVVRVVLGFMLGASWPAIHPVAAVWIPPMERSKFMSNM-MASSLGAAIT 194
            |||.|||||....:::|:||.|.|...|.:|.....:.|.|.||:||||..:.. ..|:.|:.|.
Human   132 LTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFII 196

  Fly   195 MPICGYLISVAGWASVFYLTGAVGLLWSLAWFTFVYETPATHPRISAEERREIEEAIGTTTSKKR 259
            :.:.|.:.....|..:||:.|:.|.:..|.|||.:|:.|..||.||..|:..|..::.     ::
Human   197 LCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHHPCISVREKEHILSSLA-----QQ 256

  Fly   260 PSH----VPWGQLLCSPAVWAIIICHGLAVFGFFT-------VVNQLPTFMSKILHFDIKQNGLF 313
            ||.    ||...::....:|||.:       |||:       ::..|||::|.:||.:|:.:|:.
Human   257 PSSPGRAVPIKAMVTCLPLWAIFL-------GFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVL 314

  Fly   314 SSLPYLGKYVMAVASSYLADYLRKKGTLSTTATRKLFTTFALVIPGLLMIVQVFLGYDATWSVTI 378
            ||||::......:....|||:|..:..|.....||||::..|::|.:..:...|:.  :::.:||
Human   315 SSLPFIAAASCTILGGQLADFLLSRNLLRLITVRKLFSSLGLLLPSICAVALPFVA--SSYVITI 377

  Fly   379 FSLALF--AHGAVTAGYLGNGLDIAPNFGGTIFGLANTLSSFGGFLSTSMVGALTYKDQSFHS-W 440
            ..|.|.  ......:|::.|.|||||.:...:.|::.......|.:|::..|.|.  .|.|.| |
Human   378 ILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGIISSTATGFLI--SQDFESGW 440

  Fly   441 QIVFWILAATYISAAVVFAILGSGELQPW 469
            :.||::.||..:...|.:...|..|||.|
Human   441 RNVFFLSAAVNMFGLVFYLTFGQAELQDW 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3036	NP_001260058.1	2A0114euk	19..477	CDD:129972	141/469 (30%)
CG3036	NP_001260058.1	MFS	83..461	CDD:119392	117/392 (30%)
SLC17A2	NP_001273052.1	2A0114euk	1..477	CDD:129972	146/484 (30%)
SLC17A2	NP_001273052.1	MFS	81..461	CDD:119392	117/395 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820