DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3008 and RIOK3

DIOPT Version :9

Sequence 1:	NP_608871.1	Gene:	CG3008 / 33693	FlyBaseID:	FBgn0031643	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_003822.2	Gene:	RIOK3 / 8780	HGNCID:	11451	Length:	519	Species:	Homo sapiens

Alignment Length:	581	Identity:	234/581 - (40%)
Similarity:	319/581 - (54%)	Gaps:	102/581 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PWVKTSEPVQQVNLADIMSEQYAHKLHDKELQRHTEKLKRPDEQIAPVWGSQASSPPAPNAQSIQ 68
            ||......: ..:|||:||||.|     ||||...|....|:..:|
Human    23 PWAIPQNTI-SCSLADVMSEQLA-----KELQLEEEAAVFPEVAVA------------------- 62

  Fly    69 SDAEDWEDYSALLNDEGNVAEDIQLPEDSDAVIAQLLQSQFDHEYNEELRRIERQQNKQSKVTVT 133
                           ||.......:...||.::||:||.::|.||:.:|||.|::.|..|||:::
Human    63 ---------------EGPFITGENIDTSSDLMLAQMLQMEYDREYDAQLRREEKKFNGDSKVSIS 112

  Fly   134 LNKFLRDGDAEFLHDTAEDDYEEDELEQQKHDW-DRFEDNERQLDSI--PRCGFKVNKEGEMITK 195
            ...:.:      :|...:.|..|||:     || |..:|..|....:  |:.|| :.|..::.||
Human   113 FENYRK------VHPYEDSDSSEDEV-----DWQDTRDDPYRPAKPVPTPKKGF-IGKGKDITTK 165

  Fly   196 HDPQLCAVRNAQRVMSFPPEFPTGDAAGFDMKLSNKVFNQLRAH--SRRGRSDK-HEKV--ATAE 255
            ||..:|..:|..|:.:|.|||..||..|.|:||||.|||.|:.|  |...||.: |||.  :|||
Human   166 HDEVVCGRKNTARMENFAPEFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAE 230

  Fly   256 MGLDAGTRLLLYKLINNQILEQINGIISTGKEAVILHANSDANYTGSNEHGHQSGVLVPPQLLPR 320
            ..:|..||||:||::|:.:||.|.|.||||||:|:.||     |.||.|...:..     :::|.
Human   231 KAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHA-----YGGSMEDEKEDS-----KVIPT 285

  Fly   321 ECAIKIFKTTLNEFKQRDRYIKDDYRFKDRFSKQNHRVIINMWAEKEMHNLMRMQAIGLNVPDVV 385
            |||||:|||||||||.||:|||||:||||||||.|.|.||.||||||||||.|||..|:..|.||
Human   286 ECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLARMQRAGIPCPTVV 350

  Fly   386 VLKKHVLVMRFIGDNHNAAPKLKDARLSDAELSCAYEEIVAAMHKLYNEAKLVHADMSEYNILWF 450
            :||||:|||.|||.:...|||||:.:|:..|:..||.:.:..|.:||:|..|||||:||||:||.
Human   351 LLKKHILVMSFIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWH 415

  Fly   451 EGKCWFIDVAQSVEPKHPSALEFLMRDCGNIVNFFERRGLPNIYTKEQLFEFITGLNSEVHTAAQ 515
            .||.|.|||:|||||.||..||||.|||.|:..||::.|:....::.:||..::|||
Human   416 AGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLN-------- 472

  Fly   516 LEQIHTRGASISQATAPNQEECPDELKPLEYPFELAWEKSQQD---RAAQKALQQAQDNND 573
                         .||.|:.:...|::.|        ||..:|   :..:||....:|:.|
Human   473 -------------ITADNEADFLAEIEAL--------EKMNEDHVQKNGRKAASFLKDDGD 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3008	NP_608871.1	RIO1	242..505	CDD:224632	144/265 (54%)
CG3008	NP_608871.1	RIO3_euk	278..488	CDD:270697	123/209 (59%)
RIOK3	NP_003822.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..159		12/43 (28%)
		RIO1	214..465	CDD:224632	142/260 (55%)
		RIO3_euk	253..453	CDD:270697	123/209 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148024
Domainoid	1	1.000	230	1.000	Domainoid score	I2461
eggNOG	1	0.900	-	-		E1_COG1718
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2843
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2063
Isobase	1	0.950	-	0	Normalized mean entropy	S1769
OMA	1	1.010	-	-		QHG52468
OrthoDB	1	1.010	-	-		D1238900at2759
OrthoFinder	1	1.000	-	-		FOG0007508
OrthoInspector	1	1.000	-	-		oto88577
orthoMCL	1	0.900	-	-		OOG6_107235
Panther	1	1.100	-	-	LDO	PTHR45723
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5599
SonicParanoid	1	1.000	-	-		X5639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750