Protein Alignment CG3008 and RIOK1

DIOPT Version :10

• Sequence 1: NP_608871.1
• Gene: CG3008 / 33693
• FlyBaseID: FBgn0031643
• Length: 603
• Species: Drosophila melanogaster
• Sequence 2: XP_011513235.2
• Gene: RIOK1 / 83732
• HGNCID: 18656
• Length: 580
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 160/581 - (27%)
• Similarity: 264/581 - (45%)
• Gaps: 158/581 - (27%)

  Fly   114 NEELRRIERQ-----QNKQSKVTVTLNKFLRDGDAEFLHDTAEDDYEEDELEQQKHDWDRFED-- 171
            |.:|:.::.:     ::.|..|.       .:|:.| :.|..|:.|::|:     .|||..|.
Human    38 NRDLKTVKEKDDILFEDLQDNVN-------ENGEGE-IEDEEEEGYDDDD-----DDWDWDEGVG 89

  Fly   172 ----------------NERQLDSIPRCGFKVNKEGEMITKHDPQLCAVRNAQRVMSFPPEFPTGD 220
                            |.:..||         ...:|.|..|..|....|...:..
Human    90 KLAKGYVWNGGSNPQANRQTSDS---------SSAKMSTPADKVLRKFENKINLDK--------- 136

  Fly   221 AAGFDMKLSNKVFNQLRAHSRRGRSDKH---EKV--ATAEMGLDAGTRLLLYKLINNQILEQING 280
                 :.:::.|.|::...||:..:|.:   :|.  ||.|..||..||::|:|::...|:.:|||
Human   137 -----LNVTDSVINKVTEKSRQKEADMYRIKDKADRATVEQVLDPRTRMILFKMLTRGIITEING 196

  Fly   281 IISTGKEAVILHANSDANYTGSNEHGHQSGVLVPPQLLPRECAIKIFKTTLNEFKQRDRYIKDDY 345
            .|||||||.:.|| |.||  |.:.                  ||||:||::..||.||:|:..::
Human   197 CISTGKEANVYHA-STAN--GESR------------------AIKIYKTSILVFKDRDKYVSGEF 240

  Fly   346 RFKDRFSKQNHRVIINMWAEKEMHNLMRMQAIGLNVPDVVVLKKHVLVMRFIGDNHNAAPKLKDA 410
            ||:..:.|.|.|.::..||||||.||:|:....:..|:.::|:.|||||.|||.:...||.||:.
Human   241 RFRHGYCKGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNV 305

  Fly   411 RLSDAELSCAYEEIVAAMHKLYNEAKLVHADMSEYNILWFEGKCWFIDVAQSVEPKHPSALEFLM 475
            :||:::....|.:::..|.::|.:|:|||||:||:|:|:..|..:.|||:||||..||.|||||.
Human   306 QLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQSVEHDHPHALEFLR 370

  Fly   476 RDCGNIVNFFERRGLPNIYTKEQLFEFITG-----------LNSEVHTAAQ------LEQIHTRG 523
            :||.|:.:||.|..:. :.|..:||||:|.           |:..:..|:|      ..|.|...
Human   371 KDCANVNDFFMRHSVA-VMTVRELFEFVTDPSITHENMDAYLSKAMEIASQRTKEERSSQDHVDE 434

  Fly   524 ASISQATAPNQEECPDELKPLEYPFELAWEKSQQDRAAQKALQQAQDN----------------- 571
            ....:|..|   ...:|:|..|...::..:..::|    .|:...|||
Human   435 EVFKRAYIP---RTLNEVKNYERDMDIIMKLKEED----MAMNAQQDNILYQTVTGLKKDLSGVQ 492

  Fly   572 ---------------NDNK-------TDTDKDQE---------TDDNENDSDDKEKINKTA 601
                           :|::       :|||.:::         |.|.:.|..:::|:.|.|
Human   493 KVPALLENQVEERTCSDSEDIGSSECSDTDSEEQGDHARPKKHTTDPDIDKKERKKMVKEA 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3008	NP_608871.1	RIO3_euk	278..488	CDD:270697	90/209 (43%)
RIOK1	XP_011513235.2	RIO1_euk	194..383	CDD:270698	90/209 (43%)