DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3008 and Riok3

DIOPT Version :9

Sequence 1:	NP_608871.1	Gene:	CG3008 / 33693	FlyBaseID:	FBgn0031643	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_077144.2	Gene:	Riok3 / 66878	MGIID:	1914128	Length:	519	Species:	Mus musculus

Alignment Length:	528	Identity:	227/528 - (42%)
Similarity:	304/528 - (57%)	Gaps:	74/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PWVKTSEPVQQVNLADIMSEQYAHKLHDKELQRHTEKLKRPDEQIAPVWGSQASSPPAPNAQSIQ 68
            ||. |.:.....:|.::|||:.|     ||||...|....|:..:|
Mouse    23 PWA-TPQNTVSCSLTEVMSEELA-----KELQLEEEAAAFPEVVVA------------------- 62

  Fly    69 SDAEDWEDYSALLNDEGNVAEDIQLPEDSDAVIAQLLQSQFDHEYNEELRRIERQQNKQSKVTVT 133
                           ||.......:...||.::||:||.:||.||:.:|||.|::.|..|||:::
Mouse    63 ---------------EGPFISGENIDTSSDLMLAQMLQMEFDREYDAQLRREEKKFNGDSKVSIS 112

  Fly   134 LNKFLRDGDAEFLHDTAEDDYEEDELEQQKHDW-DRFEDNERQLDSI--PRCGFKVNKEGEMITK 195
            ...:.:      :|...:.|..|||:     || |..:|..|....|  |:.|| :.|..::.||
Mouse   113 FENYRK------VHPFEDSDSSEDEV-----DWQDTRDDPYRPAKPIPTPKKGF-IGKGKDITTK 165

  Fly   196 HDPQLCAVRNAQRVMSFPPEFPTGDAAGFDMKLSNKVFNQLRAH--SRRGRSDK-HEKV--ATAE 255
            ||..:|..:|..|:.:|.|.|..||..|.|:||||.|||.|:.|  |...||.: |||.  :|||
Mouse   166 HDEVVCGRKNTARMENFAPGFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAE 230

  Fly   256 MGLDAGTRLLLYKLINNQILEQINGIISTGKEAVILHANSDANYTGSNEHGHQSGVLVPPQLLPR 320
            ..:|..||||:||::|:.:||.|.|.||||||:|:.||     |.||.|...:.|     :.:|.
Mouse   231 KAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHA-----YGGSLEDEKEDG-----KAIPT 285

  Fly   321 ECAIKIFKTTLNEFKQRDRYIKDDYRFKDRFSKQNHRVIINMWAEKEMHNLMRMQAIGLNVPDVV 385
            |||||:|||||||||.||:|||||:||||||||.|.|.||.||||||||||.|||..|:..|.||
Mouse   286 ECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLTRMQKAGIPCPTVV 350

  Fly   386 VLKKHVLVMRFIGDNHNAAPKLKDARLSDAELSCAYEEIVAAMHKLYNEAKLVHADMSEYNILWF 450
            :||||:|||.|||.:...|||||:.:||:.|:..||.:.:..|.:||||..|||||:||||:||.
Mouse   351 LLKKHILVMSFIGHDQVPAPKLKEVKLSNEEMKDAYYQTLHLMQQLYNECTLVHADLSEYNMLWH 415

  Fly   451 EGKCWFIDVAQSVEPKHPSALEFLMRDCGNIVNFFERRGLPNIYTKEQLFEFITGLN----SEVH 511
            .||.|.|||:|||||.||..||||.|||.|:..||::.|:.....:.:||..::|||    :|..
Mouse   416 AGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVTEALNERELFNAVSGLNISADNEAD 480

  Fly   512 TAAQLEQI 519
            ..|::|.:
Mouse   481 FLAEIEAL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3008	NP_608871.1	RIO1	242..505	CDD:224632	147/265 (55%)
CG3008	NP_608871.1	RIO3_euk	278..488	CDD:270697	126/209 (60%)
Riok3	NP_077144.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..159		13/42 (31%)
		RIO1	214..461	CDD:224632	145/256 (57%)
		RIO3_euk	253..453	CDD:270697	126/209 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838116
Domainoid	1	1.000	233	1.000	Domainoid score	I2397
eggNOG	1	0.900	-	-		E1_COG1718
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2843
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2037
Isobase	1	0.950	-	0	Normalized mean entropy	S1769
OMA	1	1.010	-	-		QHG52468
OrthoDB	1	1.010	-	-		D1238900at2759
OrthoFinder	1	1.000	-	-		FOG0007508
OrthoInspector	1	1.000	-	-		oto92142
orthoMCL	1	0.900	-	-		OOG6_107235
Panther	1	1.100	-	-	LDO	PTHR45723
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5599
SonicParanoid	1	1.000	-	-		X5639
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750