DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3008 and riok3

DIOPT Version :9

Sequence 1:	NP_608871.1	Gene:	CG3008 / 33693	FlyBaseID:	FBgn0031643	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_001003614.1	Gene:	riok3 / 445220	ZFINID:	ZDB-GENE-040801-133	Length:	507	Species:	Danio rerio

Alignment Length:	594	Identity:	232/594 - (39%)
Similarity:	322/594 - (54%)	Gaps:	114/594 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SPWVKTSEPVQQVNLADIMSEQYAHKLHDKELQRHTEKLKRPDEQIAPVWGSQASSPPAPNAQSI 67
            |||...:......:|||:||||.|.:|               ||:     ||..|..|
Zfish    13 SPWGAPALAPAPCSLADVMSEQLARQL---------------DEE-----GSALSQCP------- 50

  Fly    68 QSDAEDWEDYSALLNDEGNVAEDIQLPEDSDAVIAQLLQSQFDHEYNEELRRIERQQNKQSKVTV 132
                    |:|..|:..|....|    .|||.::||:||.|||.|::.:||..|::.|..|||::
Zfish    51 --------DFSPELDLAGTGEAD----TDSDLILAQMLQMQFDREFDTQLRIEEKKFNGDSKVSI 103

  Fly   133 TLNKFLRDGDAEFLHDTAEDDYEEDELEQQKHDW-DRFEDNERQL--DSIPRCGFKVNKEGEMIT 194
            :...:      ..:|...:.|..|||:     || |...|..|.:  .:.|:.|| |.|...:.|
Zfish   104 SFENY------RMVHPYEDSDSSEDEV-----DWQDTRHDPYRAVKPTTTPKKGF-VGKGKNITT 156

  Fly   195 KHDPQLCAVRNAQRVMSFPPEFPTGDAAGFDMKLSNKVFNQLRAH---SRRGRSDKHEKV--ATA 254
            |||.::|..:|..|:.:|.||...||..|.|:||||:|:|.|:.|   .:|..:..|||.  :||
Zfish   157 KHDEEICGRKNTARMDNFAPEVHVGDGIGMDLKLSNQVYNALKRHCQTEQRRSARLHEKKEHSTA 221

  Fly   255 EMGLDAGTRLLLYKLINNQILEQINGIISTGKEAVILHANSDANYTGSNEHGHQSGVLVPPQLLP 319
            |..:|..||||:||::|..|||.|||.||||||:|:.|||.     ||.|.          .::|
Zfish   222 EQAVDPKTRLLMYKMVNAGILENINGCISTGKESVVFHANG-----GSFEE----------MIVP 271

  Fly   320 RECAIKIFKTTLNEFKQRDRYIKDDYRFKDRFSKQNHRVIINMWAEKEMHNLMRMQAIGLNVPDV 384
            .||.:|:|||||||||.||:||||||||||||||.|.|.||.:|||||||||.|::..|:..|:|
Zfish   272 EECVLKVFKTTLNEFKNRDKYIKDDYRFKDRFSKLNPRKIIRLWAEKEMHNLTRIKKAGIPCPEV 336

  Fly   385 VVLKKHVLVMRFIGDNHNAAPKLKDARLSDAELSCAYEEIVAAMHKLYNEAKLVHADMSEYNILW 449
            |:||||:|||.|||.:|..|||||||.|:..::..||.:::..|.:||.:..|||||:||||:||
Zfish   337 VILKKHILVMSFIGKDHAPAPKLKDAILNSEDMKNAYYQVLNMMQRLYQDCNLVHADLSEYNMLW 401

  Fly   450 FEGKCWFIDVAQSVEPKHPSALEFLMRDCGNIVNFFERRGLPNIYTKEQLFEFITGL----NSEV 510
            .:.:.|||||:||:||.||..||||.|||.|:..||::.|:...:...:||..::||    ::|.
Zfish   402 HDRQVWFIDVSQSIEPTHPHGLEFLFRDCRNVATFFQKAGVAEAFNVFELFNTVSGLQINSDNEA 466

  Fly   511 HTAAQLEQIHTRGASISQATAPNQEECPDELKPLEYPFELAWEKSQQD---RAAQKALQQAQDNN 572
            ...||:|                                 |.||..:|   ::.:|......:.:
Zfish   467 DFLAQIE---------------------------------ALEKRNEDHVQKSGKKIFSDTYEGS 498

  Fly   573 DNKTDTDKD 581
            ..:.:||.|
Zfish   499 PPQLNTDDD 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3008	NP_608871.1	RIO1	242..505	CDD:224632	140/264 (53%)
CG3008	NP_608871.1	RIO3_euk	278..488	CDD:270697	119/209 (57%)
riok3	NP_001003614.1	RIO1	206..442	CDD:224632	137/250 (55%)
riok3	NP_001003614.1	RIO3_euk	245..440	CDD:270697	119/209 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581936
Domainoid	1	1.000	230	1.000	Domainoid score	I2397
eggNOG	1	0.900	-	-		E1_COG1718
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2843
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2013
OMA	1	1.010	-	-		QHG52468
OrthoDB	1	1.010	-	-		D1238900at2759
OrthoFinder	1	1.000	-	-		FOG0007508
OrthoInspector	1	1.000	-	-		oto40740
orthoMCL	1	0.900	-	-		OOG6_107235
Panther	1	1.100	-	-	LDO	PTHR45723
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5599
SonicParanoid	1	1.000	-	-		X5639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800