DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cf2 and ZNF646

DIOPT Version :9

Sequence 1:	NP_001350854.1	Gene:	Cf2 / 33692	FlyBaseID:	FBgn0000286	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_055514.3	Gene:	ZNF646 / 9726	HGNCID:	29004	Length:	1832	Species:	Homo sapiens

Alignment Length:	658	Identity:	129/658 - (19%)
Similarity:	198/658 - (30%)	Gaps:	252/658 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PHYCPMCHQQFERPQHVADHMQLCHGITLNAQGAIATLDGGHPQAQQHPKLSHPCFNCDEKFGNA 137
            |..|.:|.:.::....:.:|                        .|.|......|..|.:.|.|.
Human  1202 PFSCEVCGRSYKHAGSLINH------------------------RQSHQTGHFGCQACSKGFSNL 1242

  Fly   138 VDLDEHHRLAHQTP----------AFLSRCLMCSIYGIH----------SATQQPNEYKCTQCGS 182
            :.|..|.|: |..|          ||..|..:.|...:|          .||::...::|.|||.
Human  1243 MSLKNHRRI-HADPRRFRCSECGKAFRLRKQLASHQRVHMERRGGGGTRKATREDRPFRCGQCGR 1306

  Fly   183 ICTTA--MLAAGQQGFMEQQEAAVTPDDQLPAMAPRDMRLTPEEQHHQQQLQAE----------- 234
            ....|  :|...:.....|......|......||.:|.:....|...::..::.
Human  1307 TYRHAGSLLNHRRSHETGQYSCPTCPKTYSNRMALKDHQRLHSENRRRRAGRSRRTAVRCALCGR 1371

  Fly   235 --------HHHQQQHQQQQQQQQQQQ-----------ELLEQQQREMQEQAQQQQVHHHQQDQDL 280
                    ..|.::|::.:::....|           .|...|..|.| ....:.|.|.:.....
Human  1372 SFPGRGSLERHLREHEETEREPANGQGGLDGTAASEANLTGSQGLETQ-LGGAEPVPHLEDGVPR 1435

  Fly   281 AGDQ-------VALKVP-PLTVKLNKNAN---GGAIVSH-----PQVIIK-EEP----------- 317
            .|::       .:.:.| ||:....|...   ||.:.:|     ||.:.: |||
Human  1436 PGERSQSPIRAASSEAPEPLSWGAGKAGGWPVGGGLGNHSGGWVPQFLTRSEEPEDSVHRSPCHA 1500

  Fly   318 ---------LSLSDSGDVVNSVPVYAIQANPGVPAPAS--------SGVLVGTQTVPAD------ 359
                     ||..||.|..::    :.|..||..:..|        ||.|:...|...|
Human  1501 GDCQLNGPTLSHMDSWDNRDN----SSQLQPGSHSSCSQCGKTYCQSGSLLNHNTNKTDRHYCLL 1561

  Fly   360 -----------LAHKIRH------KCPDCPKTFKTPGTLAMHRKIHT------------------ 389
                       .:|...|      .||||.|.|::...||.|.:.|.
Human  1562 CSKEFLNPVATKSHSHNHIDAQTFACPDCGKAFESHQELASHLQAHARGHSQVPAQMEEARDPKA 1626

  Fly   390 ------------GEADATP---------------------------KERPYTCSYCGKSFTQSN- 414
                        |:|...|                           ||||:.|:.||:|:..:.
Human  1627 GTGEDQVVLPGQGKAQEAPSETPRGPGESVERARGGQAVTSMAAEDKERPFRCTQCGRSYRHAGS 1691

  Fly   415 --------------------------TLKQHTRIHTGEKPFHCGYCEKSFSVKDYLTKHIRTHT- 452
                                      :||.|:|.||..|...|..|.|:|.....|..|.|.|.
Human  1692 LLNHQKAHTTGLYPCSLCPKLLPNLLSLKNHSRTHTDPKRHCCSICGKAFRTAARLEGHGRVHAP 1756

  Fly   453 GEKPYTCPYCDKRFTQRSALTVHTTK-------------LHPLXGRPGGGRQLPVPAPAAPPPPT 504
            .|.|:|||:|.:.|.:|.:...|..:             :.|: ||    ..||:|.|..|..|.
Human  1757 REGPFTCPHCPRHFRRRISFVQHQQQHQEEWTVAGSGAPVAPVTGR----GDLPLPPPPTPTTPL 1817

  Fly   505 HPPNPSGP 512
            ..|:|..|
Human  1818 LDPSPQWP 1825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cf2	NP_001350854.1	COG5048	<366..>473	CDD:227381	45/197 (23%)
		C2H2 Zn finger	368..388	CDD:275368	9/19 (47%)
		C2H2 Zn finger	403..423	CDD:275368	8/46 (17%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		zf-H2C2_2	443..468	CDD:316026	11/25 (44%)
		C2H2 Zn finger	459..480	CDD:275368	6/33 (18%)
ZNF646	NP_055514.3	C2H2 Zn finger	10..31	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..47
		C2H2 Zn finger	50..70	CDD:275368
		zf-C2H2	75..97	CDD:333835
		C2H2 Zn finger	77..97	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..200
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	268..288	CDD:275368
		C2H2 Zn finger	296..316	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..346
		C2H2 Zn finger	376..396	CDD:275368
		C2H2 Zn finger	403..423	CDD:275368
		C2H2 Zn finger	467..487	CDD:275368
		C2H2 Zn finger	494..514	CDD:275368
		C2H2 Zn finger	577..597	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		C2H2 Zn finger	646..663	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..810
		C2H2 Zn finger	823..843	CDD:275368
		C2H2 Zn finger	850..870	CDD:275368
		C2H2 Zn finger	883..901	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..931
		C2H2 Zn finger	1054..1074	CDD:275368
		C2H2 Zn finger	1081..1101	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1103..1148
		C2H2 Zn finger	1205..1225	CDD:275368	4/43 (9%)
		C2H2 Zn finger	1232..1252	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1260..1280	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1294		3/19 (16%)
		C2H2 Zn finger	1301..1321	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1328..1348	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1366..1386	CDD:275368	1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1377..1481		17/104 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1509..1529		7/23 (30%)
		C2H2 Zn finger	1533..1552	CDD:275368	4/18 (22%)
		C2H2 Zn finger	1559..1579	CDD:275368	1/19 (5%)
		C2H2 Zn finger	1587..1611	CDD:275368	10/23 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1606..1672		4/65 (6%)
		C2H2 Zn finger	1679..1699	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1706..1726	CDD:275368	4/19 (21%)
		zf-H2C2_2	1718..1743	CDD:372612	11/24 (46%)
		C2H2 Zn finger	1734..1754	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1781..1832		12/49 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100