DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cf2 and Zfp280b

DIOPT Version :9

Sequence 1:NP_001350854.1 Gene:Cf2 / 33692 FlyBaseID:FBgn0000286 Length:537 Species:Drosophila melanogaster
Sequence 2:NP_803426.2 Gene:Zfp280b / 64453 MGIID:1927865 Length:534 Species:Mus musculus


Alignment Length:495 Identity:99/495 - (20%)
Similarity:139/495 - (28%) Gaps:178/495 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 IKSTTNPQEQRLPRPEDQSPAPPPPPPSSATTSTAAPATPTHQVATVIANMDTLKTAFLPNLSMD 66
            :::||.   |||      .|:.|..|.|.|.  ...||:|....:|                  |
Mouse    85 LRATTT---QRL------QPSRPAAPTSEAV--VVLPASPAESRST------------------D 120

  Fly    67 PNVHVSPHYCPMCHQQF--ERPQHVADHMQLCHG--ITLNA---QGAIATLDGGHPQAQQHPKLS 124
            ..:.:.    |:....:  ..||.|......|..  :||::   ....|.|.||           
Mouse   121 SPIAIE----PLSESDYRSSSPQVVPSSSSKCCSPLVTLSSSENSPVKAALSGG----------- 170

  Fly   125 HPCFNCDEKFGNAVDLDEHHRLAHQTPAFLSRCLMCSIYGIHSATQQPNEYKCTQCGSICTTAML 189
                          ||:|:        .::|:|        |.:.....                
Mouse   171 --------------DLNEN--------LYVSKC--------HFSINPQR---------------- 189

  Fly   190 AAGQQGFMEQQEAAVTPDDQLPAMAPRDMRLTPEEQHHQQQLQAEHHHQQQHQQQQQQQQQQQEL 254
                            ||..:..:.|....|.|....|...:              ||:....:.
Mouse   190 ----------------PDHSIEIVEPLSSALPPSGTFHTSNM--------------QQRTPSFDA 224

  Fly   255 LEQQQREMQEQAQQQQVHHHQQDQDLAGDQVALKVPPLTVKLNKNANGGAIVSHPQVIIKEEPLS 319
            .....|.:......:...|.:||..||....:......|....|    |::.           |.
Mouse   225 PNSLSRLVNGAPPSEDSAHPRQDSGLAEADFSSPASQETFDPKK----GSLT-----------LL 274

  Fly   320 LSDSGDVVNSVPVYAIQANPGVPAPASSGVLVGTQTVPADLAHKIRHKCPDCPKTFKTPGTLAMH 384
            |||.        .|......|.|...       |.|.         .|||.|.|..|.. ....|
Mouse   275 LSDF--------YYGQYKGDGKPEQK-------THTT---------FKCPSCLKALKNV-KFMNH 314

  Fly   385 RKIH-----TGEADATPKERPYTCSYCGKSFTQSNTLKQH-TRIHTGEKP-FHCGYCEKSFSVKD 442
            .|.|     .|..||.  |...||..|.:.|.....|:.| .|:||...| ..|..||.||....
Mouse   315 TKHHLELERQGSEDAW--ESHTTCLRCHRQFDSPFQLECHIDRVHTSPDPSVVCKICELSFETDQ 377

  Fly   443 YLTKHIRTH--TGEKPYTCPYCDKRFTQRSALTVHTTKLH 480
            .|.:|::.:  .||.||.|..|..|.:..:.:..|.||.|
Mouse   378 VLLQHMKDNHKPGEMPYVCQVCKYRSSGFADVETHFTKCH 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cf2NP_001350854.1 COG5048 <366..>473 CDD:227381 37/115 (32%)
C2H2 Zn finger 368..388 CDD:275368 7/19 (37%)
C2H2 Zn finger 403..423 CDD:275368 6/20 (30%)
C2H2 Zn finger 431..451 CDD:275368 7/19 (37%)
zf-H2C2_2 443..468 CDD:316026 9/26 (35%)
C2H2 Zn finger 459..480 CDD:275368 6/20 (30%)
Zfp280bNP_803426.2 DUF4195 53..221 CDD:404681 40/255 (16%)
C2H2 Zn finger 336..357 CDD:275368 6/20 (30%)
C2H2 Zn finger 366..387 CDD:275368 7/20 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24388
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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