DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cf2 and M1BP

DIOPT Version :9

Sequence 1:	NP_001350854.1	Gene:	Cf2 / 33692	FlyBaseID:	FBgn0000286	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	457	Identity:	100/457 - (21%)
Similarity:	162/457 - (35%)	Gaps:	145/457 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 CPMCHQQ---------FERPQ-HVADHMQLCHGITLNAQGAIATLDGGHPQAQQHPKLSHPCFNC 130
            |.:|.:.         |||.. .:.|:::...|:.|...|.:.               ...|..|
  Fly    13 CRVCAKYASNKRSPKLFERSNTKMIDNIEALTGLRLENYGCLP---------------DQICECC 62

  Fly   131 DEKFGNAVDLDEHHRLAHQTPAFLSRCLMCSIYGIHSATQQPNEYKCTQCGSICTTAMLAAGQQG 195
            ..:..:||.|.|             ||:......:...|::.                    :||
  Fly    63 SMELASAVKLRE-------------RCIAAQRELLLGLTEEQ--------------------RQG 94

  Fly   196 FMEQQEAAV----------TPDDQLPAMAPRDMRL-TPEEQHHQQQLQAEHHHQQQHQQQQQQQQ 249
            ......|||          ||||.......:::.| .|:|:....:::.::.:.:. .:....:.
  Fly    95 ISAFYRAAVMGEDIVQTVKTPDDDEVYATYQEIVLEEPKEEIDDTKVEYDNTYYEV-AEGHAGED 158

  Fly   250 QQQELLEQQQRE--MQEQAQQQQVHHHQQDQDL------------AGDQVALKVPPLTVKLNKNA 300
            ....|:|:...:  |.|..:|||.....:|.:|            :.|:||:    |...|:..
  Fly   159 DAASLIEEADYDSIMAEDEEQQQTLELDEDTELIVGDVNDAYVYDSDDEVAV----LDNVLDDE- 218

  Fly   301 NGGAIVSHPQVIIKEEPLSLSDSGDVVNSVPVYAIQANPGVPAP----------ASSGVLVGTQT 355
                 ..|..:::|:            .|:|          |.|          .:.||.:..|.
  Fly   219 -----YEHENIVVKK------------CSLP----------PKPKVRSDDARRRGTGGVYICEQC 256

  Fly   356 ---VPADLA---HKIRHK------CPDCPKTFKTPGTLAMHRKIHTGEADATPKERPYTCSYCGK 408
               :...:|   |..||:      |..|...|.|...|..|.:.|||       |||:.|.|||:
  Fly   257 GNHIKGRMAFELHCRRHRGDKQFGCELCQSRFCTTSELKRHMRKHTG-------ERPFACKYCGR 314

  Fly   409 SFTQSNTLKQHTRIHTGEKPFHCGYCEKSFSVKDYLTKHIRTHTGEKPYTCPYCDKRFTQRSALT 473
            .||...|..:|.|.||.|:|:.||.|.|:|:....|..|:..|:||:.|.|..|||.|...:.|:
  Fly   315 CFTDYTTRVKHERTHTNERPYVCGTCGKAFTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHLS 379

  Fly   474 VH 475
            .|
  Fly   380 TH 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cf2	NP_001350854.1	COG5048	<366..>473	CDD:227381	42/112 (38%)
		C2H2 Zn finger	368..388	CDD:275368	6/19 (32%)
		C2H2 Zn finger	403..423	CDD:275368	9/19 (47%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		zf-H2C2_2	443..468	CDD:316026	11/24 (46%)
		C2H2 Zn finger	459..480	CDD:275368	7/17 (41%)
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871	17/98 (17%)
		C2H2 Zn finger	253..273	CDD:275368	3/19 (16%)
		COG5048	276..>331	CDD:227381	22/61 (36%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	293..317	CDD:290200	12/30 (40%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		zf-H2C2_2	324..346	CDD:290200	11/21 (52%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		zf-H2C2_2	350..372	CDD:290200	10/21 (48%)
		C2H2 Zn finger	365..383	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100