DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cf2 and Kr

DIOPT Version :9

Sequence 1:	NP_001350854.1	Gene:	Cf2 / 33692	FlyBaseID:	FBgn0000286	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001261181.1	Gene:	Kr / 38012	FlyBaseID:	FBgn0001325	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	423	Identity:	103/423 - (24%)
Similarity:	157/423 - (37%)	Gaps:	97/423 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 VDLDEHHRLAHQTPAFLSRCLMCSIY---GIHSATQQPNEYKCTQCGSICTTAMLAAGQQ--GFM 197
            |.||....|:....|..|.....:||   |:..|.      ..:..|.:..|.:|||.:|  .||
  Fly    26 VHLDRSMSLSPPMSANTSATSAAAIYPAMGLQQAA------AASAFGMLSPTQLLAANRQAAAFM 84

  Fly   198 EQQEAAVTPDDQLP--------AMAPRDMRLTPEEQHHQQQLQAEHHHQQQHQQQQQQQQQQQEL 254
            .|...:...:...|        |.|.:  :..|.:..|.....|..|..........:.......
  Fly    85 AQLPMSTLANTLFPHNPAALFGAWAAQ--QSLPPQGTHLHSPPASPHSPLSTPLGSGKHPLNSPN 147

  Fly   255 LEQQQREMQEQAQQQQVHHHQQDQDLAGDQVALKVPPLTVKLNK--NANGGAIVSHPQVIIKEEP 317
            ...|..|..::|::..|....|.:             :::.:|.  :.:||             |
  Fly   148 STPQHHEPAKKARKLSVKKEFQTE-------------ISMSVNDMYHTSGG-------------P 186

  Fly   318 LSLSDSGDVVNSVPVYAIQANPGVPAPASSGVLVGTQTVPADLAHKIRHKCPDCPKTFKTPGTLA 382
            :|...||...||       .:.|      :|...|...|..|.:......|..|.::|.....|.
  Fly   187 ISPPSSGSSPNS-------THDG------AGGNAGCVGVSKDPSRDKSFTCKICSRSFGYKHVLQ 238

  Fly   383 MHRKIHTGEADATPKERPYTCSYCGKSFTQSNTLKQHTRIHTGEKPFHCGYCEKSFSVKDYLTKH 447
            .|.:.|||       |:|:.|..|.|.||:.:.||.|.|:||||||:||.:|::.|.....|.:|
  Fly   239 NHERTHTG-------EKPFECPECHKRFTRDHHLKTHMRLHTGEKPYHCSHCDRQFVQVANLRRH 296

  Fly   448 IRTHTGEKPYTCPYCDKRFTQ----RSALTVHT--------------TKLHPLXGRPGGGRQLPV 494
            :|.||||:||||..||.:|:.    :|.:.||.              .:.|.| ....|.:
  Fly   297 LRVHTGERPYTCEICDGKFSDSNQLKSHMLVHNGEKPFECERCHMKFRRRHHLMNHKCGIQ---- 357

  Fly   495 PAPAAPPPPTHPPNPSG--PGAPPPLSADTDTD 525
                :||.|...|..||  |.|...::.:..|:
  Fly   358 ----SPPTPALSPAMSGDYPVAISAIAIEASTN 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cf2	NP_001350854.1	COG5048	<366..>473	CDD:227381	44/110 (40%)
		C2H2 Zn finger	368..388	CDD:275368	5/19 (26%)
		C2H2 Zn finger	403..423	CDD:275368	9/19 (47%)
		C2H2 Zn finger	431..451	CDD:275368	6/19 (32%)
		zf-H2C2_2	443..468	CDD:316026	14/24 (58%)
		C2H2 Zn finger	459..480	CDD:275368	7/38 (18%)
Kr	NP_001261181.1	C2H2 Zn finger	224..244	CDD:275368	5/19 (26%)
		zf-H2C2_2	237..261	CDD:290200	11/30 (37%)
		C2H2 Zn finger	252..272	CDD:275368	9/19 (47%)
		zf-H2C2_2	264..289	CDD:290200	14/24 (58%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		zf-H2C2_2	292..316	CDD:290200	13/23 (57%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		zf-H2C2_2	321..345	CDD:290200	3/23 (13%)
		C2H2 Zn finger	336..352	CDD:275368	2/15 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	54	1.000	Inparanoid score	I1809
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050