DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cf2 and Zfat

DIOPT Version :9

Sequence 1:	NP_001350854.1	Gene:	Cf2 / 33692	FlyBaseID:	FBgn0000286	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_006241775.1	Gene:	Zfat / 362925	RGDID:	1310886	Length:	1235	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	84/389 - (21%)
Similarity:	140/389 - (35%)	Gaps:	97/389 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 RLAHQTPAFLSRCLMCSIYGIHSATQQPNEYKCTQCGSICTTAMLAAGQQGFMEQQEAAVTPDDQ 209
            |.|..|..|:.:|  |:::       .||:      ..:.|......|::|        |..||.
  Rat     4 RAAENTAIFMCKC--CNLF-------SPNQ------SELVTHVSEKHGEEG--------VNVDDV 45

  Fly   210 LPAMAPRDMRLTPEEQHHQQQLQAEHHHQQQHQQQQQQQQQQQELLEQQQREMQEQAQQQQVHHH 274
            :..:.|.:....|.......:.......:.:.:...::...::|::|.....:
  Rat    46 IIPLRPLNTPENPNPSKGGDEFLVMKRKRGRPKGSTKKPSTEEEVVENLVSPI------------ 98

  Fly   275 QQDQDLAGDQVALKVPPLTVKLN----KNANGGAIVSHPQVIIKEEPLSLSDSGDVVN------- 328
             :|..||.:: ..::.|.:::.:    |.:|...:..|..:|:    |:|.:.||..|
  Rat    99 -EDGPLAPEE-GSRLAPSSLECSKCCRKFSNTRQLRKHICIIV----LNLGEEGDAGNESDLDLE 157

  Fly   329 -------------------SVPVYAIQAN-----PGVPAPASSGVLVGTQTVPADLAHKIRHKCP 369
                               :..|..|...     .|...|..|.||...:.:|.  |.||.....
  Rat   158 KTYKEDDREKTSKRPRAQKTEKVQKISGKEAGQLSGAKKPIISVVLTAHEAIPG--ATKIIPVEA 220

  Fly   370 DCPKTFKTP-----GTLAMHRKIHTGEADATPKERP-------------YTCSYCGKSFTQSNTL 416
            ..|:|...|     ..|...|.........||.|:|             :||.||.|.|...::|
  Rat   221 GPPETGAPPPETTAADLVPRRGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYCNKVFKFKHSL 285

  Fly   417 KQHTRIHTGEKPFHCGYCEKSFSVKDYLTKHIRTHTGEKPYTCPYCDKRFTQRSALTVHTTKLH 480
            :.|.||||.|||:.|..|..:.::|..|..|:|.||||| :.|.||......:..|.||..::|
  Rat   286 QAHLRIHTNEKPYKCSQCSYASAIKANLNVHLRKHTGEK-FACDYCSFTCLSKGHLKVHIERVH 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cf2	NP_001350854.1	COG5048	<366..>473	CDD:227381	38/124 (31%)
		C2H2 Zn finger	368..388	CDD:275368	5/24 (21%)
		C2H2 Zn finger	403..423	CDD:275368	8/19 (42%)
		C2H2 Zn finger	431..451	CDD:275368	6/19 (32%)
		zf-H2C2_2	443..468	CDD:316026	11/24 (46%)
		C2H2 Zn finger	459..480	CDD:275368	6/20 (30%)
Zfat	XP_006241775.1	C2H2 Zn finger	272..292	CDD:275368	8/19 (42%)
		zf-H2C2_2	284..306	CDD:290200	11/21 (52%)
		C2H2 Zn finger	300..320	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..348	CDD:275368	6/20 (30%)
		C2H2 Zn finger	355..395	CDD:275368
		C2H2 Zn finger	405..425	CDD:275368
		C2H2 Zn finger	433..453	CDD:275368
		C2H2 Zn finger	459..477	CDD:275368
		C2H2 Zn finger	737..757	CDD:275368
		C2H2 Zn finger	765..815	CDD:275368
		C2H2 Zn finger	825..844	CDD:275368
		C2H2 Zn finger	875..896	CDD:275368
		C2H2 Zn finger	904..924	CDD:275368
		zf-H2C2_2	916..941	CDD:290200
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	961..981	CDD:275368
		C2H2 Zn finger	989..1010	CDD:275368
		C2H2 Zn finger	1036..1054	CDD:275368
		zf-C2H2	270..292	CDD:278523	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100