DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cf2 and ZNF423

DIOPT Version :9

Sequence 1:	NP_001350854.1	Gene:	Cf2 / 33692	FlyBaseID:	FBgn0000286	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_006721234.1	Gene:	ZNF423 / 23090	HGNCID:	16762	Length:	1299	Species:	Homo sapiens

Alignment Length:	247	Identity:	60/247 - (24%)
Similarity:	103/247 - (41%)	Gaps:	55/247 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 QQQQQQQQQQQELLEQQQR-EMQEQAQQQQVH---HHQQD-QDLAG--DQVALKVP------PLT 293
            |:..:..:.:..:..|::| |..|..:.:.::   |.||| :.||.  |..|.:.|      |..
Human    51 QKTSRALEDRNSVTSQEERNEDDEDMEDESIYTCDHCQQDFESLADLTDHRAHRCPGDGDDDPQL 115

  Fly   294 VKLNKNANGGAIVSHPQVIIKEEPLSLSDSGDVVNSVPVYAIQANPGVPAPASSGVLVGTQTVPA 358
            ..:..:.:...:.|..|:|.....|.|.:.            :...|:|.|
Human   116 SWVASSPSSKDVASPTQMIGDGCDLGLGEE------------EGGTGLPYP-------------- 154

  Fly   359 DLAHKIRHKCPDCPKTFKTPGTLAMHRKIHTGEADATPKERPYTCSYCGKSFTQSNTLKQHTRIH 423
                     |..|.|:|.....|..|.:||:.:.       |:.|:||.:.|....:..:|.::|
Human   155 ---------CQFCDKSFIRLSYLKRHEQIHSDKL-------PFKCTYCSRLFKHKRSRDRHIKLH 203

  Fly   424 TGEKPFHCGYCEKSFSVKDYLTKHIRTHTGEKPYTCPYCDKRFTQRSALTVH 475
            ||:|.:||..||.:||..|:|..|::||:..||:.|..|.:.|:..|:|..|
Human   204 TGDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCTVCKRGFSSTSSLQSH 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cf2	NP_001350854.1	COG5048	<366..>473	CDD:227381	35/106 (33%)
		C2H2 Zn finger	368..388	CDD:275368	6/19 (32%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..451	CDD:275368	8/19 (42%)
		zf-H2C2_2	443..468	CDD:316026	9/24 (38%)
		C2H2 Zn finger	459..480	CDD:275368	6/17 (35%)
ZNF423	XP_006721234.1	C2H2 Zn finger	155..175	CDD:275368	6/19 (32%)
		C2H2 Zn finger	183..203	CDD:275368	5/19 (26%)
		COG5048	209..610	CDD:227381	19/47 (40%)
		C2H2 Zn finger	211..231	CDD:275368	8/19 (42%)
		C2H2 Zn finger	239..259	CDD:275368	6/17 (35%)
		C2H2 Zn finger	280..299	CDD:275368
		C2H2 Zn finger	426..447	CDD:275368
		C2H2 Zn finger	458..479	CDD:275368
		C2H2 Zn finger	497..516	CDD:275368
		C2H2 Zn finger	679..699	CDD:275368
		C2H2 Zn finger	709..730	CDD:275368
		C2H2 Zn finger	737..758	CDD:275368
		C2H2 Zn finger	767..788	CDD:275368
		C2H2 Zn finger	798..818	CDD:275368
		C2H2 Zn finger	824..842	CDD:275368
		C2H2 Zn finger	903..924	CDD:275368
		C2H2 Zn finger	947..967	CDD:275368
		C2H2 Zn finger	976..996	CDD:275368
		C2H2 Zn finger	1215..1235	CDD:275368
		C2H2 Zn finger	1246..1267	CDD:275368
		C2H2 Zn finger	1276..1292	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100