DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cf2 and ZNF274

DIOPT Version :9

Sequence 1:NP_001350854.1 Gene:Cf2 / 33692 FlyBaseID:FBgn0000286 Length:537 Species:Drosophila melanogaster
Sequence 2:NP_598009.1 Gene:ZNF274 / 10782 HGNCID:13068 Length:653 Species:Homo sapiens


Alignment Length:567 Identity:129/567 - (22%)
Similarity:210/567 - (37%) Gaps:197/567 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 PNLSMDPNVHVSPHYCPMCHQQFERPQHVADHMQLCHGITLN---------------AQGAIATL 110
            |.|.:||.:...|...|:.            ::::...:|||               |:....:.
Human    88 PELQLDPKLDPLPAESPLM------------NIEVVEVLTLNQEVAGPRNAQIQALYAEDGSLSA 140

  Fly   111 DGGHPQAQQHPKLSHP-----------CFNCDEKFGNAVDLDEHHRLAHQ--------------- 149
            |....|.||..|  ||           .|...:..|....||:...|.||               
Human   141 DAPSEQVQQQGK--HPGDPEAARQRFRQFRYKDMTGPREALDQLRELCHQWLQPKARSKEQILEL 203

  Fly   150 ---------TPAFL---------SRC--LMCSIYGIHSATQ-------QPNEYKCTQCGSICTTA 187
                     .|..|         ..|  ::..:.|:...::       ||.|      |:.|...
Human   204 LVLEQFLGALPVKLRTWVESQHPENCQEVVALVEGVTWMSEEEVLPAGQPAE------GTTCCLE 262

  Fly   188 MLAAGQQGFMEQQEAAVTPDDQLP-------------------AMAP------RDMRL------- 220
            :.|..::   :|::||:.|...||                   .:.|      ||:.|       
Human   263 VTAQQEE---KQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHLV 324

  Fly   221 ------------------TPEEQHHQQQLQAEHHHQQ-------QHQQQQQQQQQQQELLEQQQR 260
                              .|||: ....|:.:...:.       :...|...|:.|..:|:|.:.
Human   325 SVGWETTLENKELAPNSDIPEEE-PAPSLKVQESSRDCALSSTLEDTLQGGVQEVQDTVLKQMES 388

  Fly   261 EMQEQAQQQQVHHHQQDQDLAG----DQVALKVPPLTVKLN---KNANGGAIVSHPQVIIKEEP- 317
            ..::...|::...:::.|..:|    :||:|:      |::   ..||.||:.:: ||::.:.| 
Human   389 AQEKDLPQKKHFDNRESQANSGALDTNQVSLQ------KIDNPESQANSGALDTN-QVLLHKIPP 446

  Fly   318 ---LSLSDSGDVVNSVPVYAIQANPGV----------PAPASSGVLV----GTQTVPADLAHKIR 365
               |...||       .|.:::.|..|          .|...:|...    .|:.:.....||..
Human   447 RKRLRKRDS-------QVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQITFIRIHKGS 504

  Fly   366 H--KCPDCPKTFKTPGTLAMHRKIHTGEADATPKERPYTCSYCGKSFTQSNTLKQHTRIHTGEKP 428
            .  :|.:|.|.|:.|...::|:|||||       ||||.|..|||.|.||::|.||.|:|:||:|
Human   505 QVCRCSECGKIFRNPRYFSVHKKIHTG-------ERPYVCQDCGKGFVQSSSLTQHQRVHSGERP 562

  Fly   429 FHCGYCEKSFSVKDYLTKHIRTHTGEKPYTCPYCDKRFTQRSALTVH 475
            |.|..|.::|:.:..:::|:|||||.|||.|..|.|.|.|.|.|..|
Human   563 FECQECGRTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRH 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cf2NP_001350854.1 COG5048 <366..>473 CDD:227381 49/108 (45%)
C2H2 Zn finger 368..388 CDD:275368 7/19 (37%)
C2H2 Zn finger 403..423 CDD:275368 11/19 (58%)
C2H2 Zn finger 431..451 CDD:275368 5/19 (26%)
zf-H2C2_2 443..468 CDD:316026 13/24 (54%)
C2H2 Zn finger 459..480 CDD:275368 8/17 (47%)
ZNF274NP_598009.1 KRAB 14..73 CDD:214630
KRAB 14..53 CDD:279668
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..159 7/21 (33%)
SCAN 157..269 CDD:128708 17/117 (15%)
SCAN 157..245 CDD:280241 11/87 (13%)
KRAB 287..>327 CDD:214630 4/39 (10%)
KRAB 287..326 CDD:279668 4/38 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 339..359 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414 3/25 (12%)
COG5048 <389..644 CDD:227381 76/242 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..485 8/43 (19%)
C2H2 Zn finger 481..501 CDD:275368 2/19 (11%)
C2H2 Zn finger 509..529 CDD:275368 7/19 (37%)
zf-H2C2_2 521..546 CDD:290200 15/31 (48%)
C2H2 Zn finger 537..557 CDD:275368 11/19 (58%)
zf-H2C2_2 549..573 CDD:290200 11/23 (48%)
zf-C2H2 563..585 CDD:278523 6/21 (29%)
C2H2 Zn finger 565..585 CDD:275368 5/19 (26%)
zf-C2H2 591..613 CDD:278523 9/19 (47%)
C2H2 Zn finger 593..613 CDD:275368 8/17 (47%)
zf-H2C2_2 605..630 CDD:290200 2/5 (40%)
C2H2 Zn finger 621..641 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..653
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4508
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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