DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smog and gpr158

DIOPT Version :9

Sequence 1:	NP_001245881.1	Gene:	smog / 33690	FlyBaseID:	FBgn0051660	Length:	951	Species:	Drosophila melanogaster
Sequence 2:	XP_002933190.2	Gene:	gpr158 / 779597	XenbaseID:	XB-GENE-950420	Length:	1291	Species:	Xenopus tropicalis

Alignment Length:	882	Identity:	214/882 - (24%)
Similarity:	359/882 - (40%)	Gaps:	155/882 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 LLIVGLATAT------------------------ASPSPSPSHAPFGRESRRDALLAYYKRAHLP 173
            ||.|||..|:                        :||| :|.|:....::...|.||......||
Frog    11 LLCVGLVAASRRDSLEGRTAAHPQQHFPGRYPIYSSPS-NPQHSALWIQTTESAPLAQTLAQDLP 74

  Fly   174 QSSSSGISLGHKYHLLHDANGLDFDELTPTASSVSALSRAERFRLRK-RSATPTTPATAAGVTSL 237
            :..:|.:..|                   .|..:.|...::.:.|.. ..|:|..|      |.|
Frog    75 KHVASFLYKG-------------------AAGELKAALCSQSYELSSLPGASPGHP------TLL 114

  Fly   238 DVATAAAAATDAAAKDAGSGKKPEEKCEPKV-------LETLPDEPFYDYTDIAEDAARQFIEFL 295
            .........|:.......|.|..|...|..|       ...|..||     .|...|....:|
Frog   115 RAVDILLHGTNFLNMMLQSNKSREHNWERDVEWYYALIKSILEGEP-----AIFRSAVAFNVE-- 172

  Fly   296 SGKFPNANTPIAIDEPTRAE-------VSRRANGIASYALNEDDNLLAFAIAAPSIHTVVVKFRD 353
                |:::.|......||.|       :|..|:|..:.....|           .:||  .|.|.
Frog   173 ----PSSHVPQVFLRATREEGKIHLQDLSASAHGPGNATWEHD-----------WLHT--FKHRS 220

  Fly   354 NVTIPPDQVHNKAYLGSYWRELGAAWNSTDGTQEWGAPFRDCNLLTRRWLWPFRISFSEHRIK-- 416
            ...:....:|........|:: |.::.:.....:|.:|:.:|.....|..|...:|.:.:.:|
Frog   221 RPHLHKRLLHGAKTFDDGWKK-GNSYVTDRSHVKWSSPYLECENGKYRPHWLLSLSAAFYGLKPN 284

  Fly   417 ---------VVAAAFIAADEDVCNDGLEEVFGRRHGCDRNTTFCLLTENKPAATRDVYTCLCRES 472
                     .|.......|.|.|::  |..|...|.|..|::.|:.|:.. ......|.|.|:..
Frog   285 LVREFRGVLKVDVNLQNIDIDQCSN--EGWFSGTHRCQHNSSKCIPTKGL-GFVLGAYKCTCKAG 346

  Fly   473 YYLPNSTL--QGFRG-------DRVELSEGYDNYSCIPCPGGCTNCDSNGVCLTFQEEEVLNVDA 528
            :|.|:...  .||:.       .|.|:||  :.|.|:||..||:||..:..|  :.:|     |.
Frog   347 FYYPHGMFSENGFQRPNMVNHFPRGEISE--EEYKCLPCREGCSNCTDDAPC--YAQE-----DK 402

  Fly   529 CLRLLVAIVLGACILCCIVLGVIVFRQRKCKAI-ASGMWTVLETILLGIVLLYASVAVHFFPAST 592
            .||:.:......|:|...:..::|:..|:.|:: |||: .:||.||.|.:|||..|.:.:|..||
Frog   403 YLRIAIISFQAFCMLLDFISMLVVYSFRRAKSVRASGL-VLLEVILFGSLLLYFPVVILYFEPST 466

  Fly   593 ERCLLEPWLRELGFITCYGAIILKLYRHLVDFRTRKAHRW-VLRDVDLLKYLGTMVFAVICYMAA 656
            .||:|..|:|.||:.|.||.:.|||||.|..|.:|.|.|. .:....:::.|..::..|:.::.|
Frog   467 FRCILLRWVRLLGYATVYGTVTLKLYRVLKVFLSRTAQRIPYMTSGRVIRMLSVILLLVLWFLVA 531

  Fly   657 FTASSLDLLES-----AQLESLREADTNTCHPLKWELVTQTSEMLILCFGLHLSIASRNANTQFR 716
            :|::....::.     .|.|:........|...:|:.:...:|.|.|.:|::|..|.|...:.|.
Frog   532 WTSAVCQNMDRNIPLIVQGETSDNLQFKMCLIDRWDYMMAVAEFLFLLWGVYLCYAVRTVPSAFH 596

  Fly   717 ERQFLVTALTLEFLVSSSFYFLRFVYLPEMSPSAILLALFIRSQLTNSFALGLIFVPKLWYQHKQ 781
            |.:::..|:..|.:.|:.|:.:|||...::.|..:|:..|:.:.||.:..:||:.:||....|..
Frog   597 EPRYMAFAVHNELIFSALFHTIRFVLASKLQPDWMLMLFFVHTHLTVTVTVGLLLIPKFSRSHNN 661

  Fly   782 VRSLAYDLSIRLPVDAFKGTSHDAGQRLGGGYAGLCLGDPDIGELTISEMSPEDIRAELKRLYTQ 846
            .|.   |::    .:|::       ..|..|.:|..|........:...:.|||||.|||:||||
Frog   662 PRD---DIA----AEAYE-------DELDLGRSGSYLNSSITSAWSEHSLDPEDIREELKKLYTQ 712

  Fly   847 LEIMKNKTLRQDNPHISKRRGGRKAGHRRF---------SLQKKGSKDKALSAKHRSNKHHQDIE 902
            |||.|.|.:..:|||:.|:|..:|...|..         |:.::.||::..:..|.:.|:  ::.
Frog   713 LEIYKRKKMIANNPHLQKKRCSKKGLGRSIMRRITEIPDSVSRQCSKEEKDTTDHGNPKN--NVG 775

  Fly   903 ITEAEPSRTPEDSVCSAEGPTDTYAEISGVSHSMLSH 939
            .::..|..:...:..|.|.|:.........|||...|
Frog   776 SSKKHPQESVTHNAKSKEEPSKHKLYSMKKSHSSYDH 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smog	NP_001245881.1	7tm_3	542..776	CDD:278433	72/240 (30%)
gpr158	XP_002933190.2	EGF_CA	303..348	CDD:214542	13/47 (28%)
		7tmC_GPR158-like	403..660	CDD:320420	75/257 (29%)
		TM helix 1	403..428	CDD:320420	5/24 (21%)
		TM helix 2	440..461	CDD:320420	9/21 (43%)
		TM helix 3	470..494	CDD:320420	12/23 (52%)
		TM helix 4	514..534	CDD:320420	3/19 (16%)
		TM helix 5	563..589	CDD:320420	7/25 (28%)
		TM helix 6	597..620	CDD:320420	5/22 (23%)
		TM helix 7	629..654	CDD:320420	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR32546
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3555
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.130