DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smog and GPR158

DIOPT Version :9

Sequence 1:	NP_001245881.1	Gene:	smog / 33690	FlyBaseID:	FBgn0051660	Length:	951	Species:	Drosophila melanogaster
Sequence 2:	NP_065803.2	Gene:	GPR158 / 57512	HGNCID:	23689	Length:	1215	Species:	Homo sapiens

Alignment Length:	911	Identity:	230/911 - (25%)
Similarity:	358/911 - (39%)	Gaps:	187/911 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 YSLLVLLI---VGLATATASPSP--------------------------SPSHAPFGRESRRDAL 163
            |.||:.|:   :||....||..|                          |.|.||:.| |....:
Human     6 YPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSR-STDGTI 69

  Fly   164 LAYYKRAHLPQSSSSGISLGHKYHLLHDANGLDFDELTPTASSVSALSRAERFRLRKRSATPTTP 228
            ||......:|...:|.:..|.. |.|..||.....||........||:          ||.|:..
Human    70 LAQKLAEEVPMDVASYLYTGDS-HQLKRANCSGRYELAGLPGKWPALA----------SAHPSLH 123

  Fly   229 ATAAGVTSLDVATAAAAATDAAAKDAGSGKKPEEKCEPK-------VLETLPDEPFYDYTDIAED 286
                  .:||..|.|....:...:   |.|..|:..:..       |...|..||         .
Human   124 ------RALDTLTHATNFLNVMLQ---SNKSREQNLQDDLDWYQALVWSLLEGEP---------S 170

  Fly   287 AARQFIEFLSGKFPNANTPIAIDEPTRAEVSRRANGIASYALNEDDNLLAFAIAAPSIHTVVVKF 351
            .:|..|.|.:... :|..|....:.||                |:..:|...:::.:.|..
Human   171 ISRAAITFSTDSL-SAPAPQVFLQATR----------------EESRILLQDLSSSAPHLA---- 214

  Fly   352 RDNVTIPPDQVHNKAYLGSYWRE-------------LGAAWNSTDGTQ------EWGAPFRDCNL 397
              |.|:..:..|.   |...||.             ||.:|...||..      :|..|:.:|..
Human   215 --NATLETEWFHG---LRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYLECEN 274

  Fly   398 LTRRWLWPFRISFS----------EHR-IKVVAAAFIAADEDVC-NDGLEEVFGRRHGCDRNTTF 450
            .:.:..|...:|.:          |.| :..|.......|.|.| :||.   |...|.|..|.:.
Human   275 GSYKPGWLVTLSSAIYGLQPNLVPEFRGVMKVDINLQKVDIDQCSSDGW---FSGTHKCHLNNSE 336

  Fly   451 CLLTENKPAATRDVYTCLCRESYYLPN-STLQGFR---------GDRVELSEGYDNYSCIPCPGG 505
            |:..:.. ......|.|:|:..:|.|. ..:..||         |...::||  :.|.|:||..|
Human   337 CMPIKGL-GFVLGAYECICKAGFYHPGVLPVNNFRRRGPDQHISGSTKDVSE--EAYVCLPCREG 398

  Fly   506 CTNCDSNGVCLTFQEEEVLNVDACLRLLVAIVLGACILCCIVLGVIVFRQRKCKAI-ASGMWTVL 569
            |..|..:..|  |.:|     |..|||.:......|:|...|..::|:..||.|:| |||: .:|
Human   399 CPFCADDSPC--FVQE-----DKYLRLAIISFQALCMLLDFVSMLVVYHFRKAKSIRASGL-ILL 455

  Fly   570 ETILLGIVLLYASVAVHFFPASTERCLLEPWLRELGFITCYGAIILKLYRHLVDFRTRKAHRW-V 633
            ||||.|.:|||..|.:.:|..||.||:|..|.|.|||.|.||.:.|||:|.|..|.:|.|.|. .
Human   456 ETILFGSLLLYFPVVILYFEPSTFRCILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPY 520

  Fly   634 LRDVDLLKYLGTMVFAVICYMAAFTASSLDLLESAQLESLREADT------NTCHPLKWELVTQT 692
            :....:::.|..::..|..::..:|:|....||. |:..:.:..|      |.|...:|:.:|..
Human   521 MTGGRVMRMLAVILLVVFWFLIGWTSSVCQNLEK-QISLIGQGKTSDHLIFNMCLIDRWDYMTAV 584

  Fly   693 SEMLILCFGLHLSIASRNANTQFRERQFLVTALTLEFLVSSSFYFLRFVYLPEMSPSAILLALFI 757
            :|.|.|.:|::|..|.|...:.|.|.:::..|:..|.::|:.|:.:|||....:....:|:..|.
Human   585 AEFLFLLWGVYLCYAVRTVPSAFHEPRYMAVAVHNELIISAIFHTIRFVLASRLQSDWMLMLYFA 649

  Fly   758 RSQLTNSFALGLIFVPKLWYQHKQVRSLAYDLSIRLPVDAFKGTSHDAGQRLGGGYAGLCLGDPD 822
            .:.||.:..:||:.:||..:.....|.   |::    .:|::       ..|..|.:|..|....
Human   650 HTHLTVTVTIGLLLIPKFSHSSNNPRD---DIA----TEAYE-------DELDMGRSGSYLNSSI 700

  Fly   823 IGELTISEMSPEDIRAELKRLYTQLEIMKNKTLRQDNPHISKRRGGRKAGHRRF---------SL 878
            ....:...:.|||||.|||:||.||||.|.|.:..:|||:.|:|..:|...|..         ::
Human   701 NSAWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETV 765

  Fly   879 QKKGSKDKALSAKHRSNKHHQDIEITEAEPSRTPEDSVCSAEGPTDTYAEISGVSHSMLSHSMVS 943
            .::.||:....|.|.:.|.      |.......||.|..:.:...:|..  :.|.....|||...
Human   766 SRQCSKEDKEGADHGTAKG------TALIRKNPPESSGNTGKSKEETLK--NRVFSLKKSHSTYD 822

  Fly   944 H 944
            |
Human   823 H 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smog	NP_001245881.1	7tm_3	542..776	CDD:278433	79/241 (33%)
GPR158	NP_065803.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..66		9/43 (21%)
		7tm_3	428..667	CDD:278433	78/240 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	757..999		15/75 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1164
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4982
eggNOG	1	0.900	-	-		E1_KOG4418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7472
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103956
Panther	1	1.100	-	-	O	PTHR32546
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3555
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.790