DRSC/TRiP Functional Genomics Resources

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Protein Alignment smog and GPR179

DIOPT Version :10

Sequence 1:NP_001245881.1 Gene:smog / 33690 FlyBaseID:FBgn0051660 Length:951 Species:Drosophila melanogaster
Sequence 2:NP_001004334.3 Gene:GPR179 / 440435 HGNCID:31371 Length:2367 Species:Homo sapiens


Alignment Length:415 Identity:84/415 - (20%)
Similarity:155/415 - (37%) Gaps:112/415 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 KKSQDDPHAR-------EITTLKME------IQQIMKG------NYRYFMQKEIFEQP----ESV 332
            :||.:..|.|       ||.|||.|      :..::|.      |.:.||:.....|.    |::
Human    66 RKSFNFRHQRMIAGQYKEIETLKAEQAETTMLLSLVKSPKNLDINQKNFMELRFLLQTKGDYEAL 130

  Fly   333 INTMRGRVNFESKKVTLGGIKDYIPEIKR----CRRLMLIACGTSYHSAVATRQLLEELTELPVM 393
            |::|         ||.||.:.|.|.:::|    .|:|.|     ....|...::|..::..|...
Human   131 ISSM---------KVLLGELDDKIVQMERKITNQRQLFL-----RTQEANNPKRLQRQIHVLESR 181

  Fly   394 VELAS----DFLDRNTPIYR--DDVCFFISQSGETADTLMALRYCKQRGALIVGITNTVGSSICR 452
            :.|.:    ..|..|:.:.:  :|:.|..:........|.. |...|:..:.|.|..        
Human   182 LNLVTVHFDTMLTSNSQLRKEIEDLLFEKAAYDHVYQQLQR-RLQTQKKTMNVAIEQ-------- 237

  Fly   453 ESHCGVHVNAGPEIGVASTKAYTSQFISLVMFALVMSEDRLSLQNRRLEI--IEGLRNLDAHIKQ 515
                             |.:||..:..::...|.:....:..:....|||  :|.|.:.:..:|.
Human   238 -----------------SAQAYEQRVEAMARMAAMKDRQQKDISQYNLEIRELERLYDHETKLKS 285

  Fly   516 VLML---DQRVLE---IAQDLYQQKSLLIMGRGYNFATCMEGALKVKELT-----YMHSEGIMAG 569
            .|:.   |:...|   ..|:..:.|.|...|:|.:||:.....|::.:|.     ...:|..:|.
Human   286 FLLAKLNDRSEFEDQAKKQEDVKSKKLGKKGKGESFASYEVAHLRLLKLAENGDLNQLTEDFLAK 350

  Fly   570 ELKHGP----LALVDDTMPIVMIIMRDPVHQKCMN--------ALQQVTAREGRPIII--CEEGD 620
            |.|:..    :..:::.|        :.:|:|...        ..||.|:.||...|:  .||..
Human   351 EEKNFARFTYVTELNNDM--------ETMHKKTQRIQDDIINLRSQQQTSHEGTRSILKQMEEKL 407

  Fly   621 RETM----AFASKALEIPRTVDALQ 641
            |:|.    .:.:|..|:.:|::.|:
Human   408 RKTTQEADIYETKYKEMSKTLEYLK 432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smogNP_001245881.1 7tmC_GPR158-like 529..780 CDD:320420 29/136 (21%)
TM helix 1 529..554 CDD:320420 6/24 (25%)
TM helix 2 566..587 CDD:320420 4/24 (17%)
TM helix 3 596..620 CDD:320420 9/33 (27%)
TM helix 4 639..659 CDD:320420 1/3 (33%)
TM helix 5 683..709 CDD:320420
TM helix 6 717..740 CDD:320420
TM helix 7 749..774 CDD:320420
GPR179NP_001004334.3 Cache-like region. /evidence=ECO:0000250|UniProtKB:Q5T848 62..245 44/218 (20%)
EGF_CA 278..327 CDD:238011 11/48 (23%)
7tmC_GPR158-like 387..635 CDD:320420 14/46 (30%)
TM helix 2 416..437 CDD:320420 4/17 (24%)
TM helix 3 446..470 CDD:320420
TM helix 4 490..510 CDD:320420
TM helix 5 539..565 CDD:320420
TM helix 6 573..596 CDD:320420
TM helix 7 605..630 CDD:320420
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..818
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 869..932
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1039..1083
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1098..1198
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1247..1431
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1537..1557
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1577..1672
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1723..1757
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1823..1852
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1886..2108
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2133..2212
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2308..2367
Blue background indicates that the domain is not in the aligned region.

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