Protein Alignment smog and gpr-158

DIOPT Version :10

• Sequence 1: NP_001245881.1
• Gene: smog / 33690
• FlyBaseID: FBgn0051660
• Length: 951
• Species: Drosophila melanogaster
• Sequence 2: NP_493572.2
• Gene: gpr-158 / 3565054
• WormBaseID: WBGene00009558
• Length: 594
• Species: Caenorhabditis elegans
• Alignment Length: 746
• Identity: 190/746 - (25%)
• Similarity: 294/746 - (39%)
• Gaps: 185/746 - (24%)

  Fly   225 PTTPATAAG----------VTSLDVATAAAAATDAAAKDAGSGKKPEEKCEPKVLETLPDEPFYD 279
            |||..:::.          :..|..:....:.|..|......|.:|    ..::|.:| |:| |.
 Worm     4 PTTTTSSSSSYTPWYHHIFIIFLQYSLFHISPTFGARNTVTEGGQP----LTELLSSL-DQP-YP 62

  Fly   280 YTDIAEDAARQFIEFLSGKFPNANTPIAIDEPTRAEVSRRANGIASYALNEDDNLLAFAIAAPSI 344
            ...:.|  |..|:          :|.:|:..|...::   |:..|:::.|.|..||..:
 Worm    63 CGHVVE--AEHFL----------STAVALKFPRLIQL---AHFFANHSKNFDPQLLDKS------ 106

  Fly   345 HTVVVKFRDNVTIPPDQVHNKAYLGSYWRELGAAWNSTDGTQEWGAPFRDCNLLTRRWLWPFRIS 409
                 .|:.   |||..|       |:.|.          |..:|... :|.....||| | |:.
 Worm   107 -----SFQQ---IPPFDV-------SFARR----------THFYGLQL-NCTGNNHRWL-P-RLV 143

  Fly   410 FSEHRIKVVAAAFIAADEDVCNDGLEEVFGRRHGCDRNTTFCLLTENKPAATR------DVYTCL 468
            |..|                               |.|.:      ||.|...      ||..|.
 Worm   144 FVSH-------------------------------DPNNS------NKKAYLTLQLDQFDVDMCS 171

  Fly   469 CRESYYLPNSTLQGFRGDRVELSEGYDNYSCIPCPGGCTNCDSNGVCLTFQEEEVLNVDACLRLL 533
            ....:.....|:.|  |.||...             .|.|.|...:|.|..|..        |.:
 Worm   172 AVNCHTKCTWTVHG--GLRVSAK-------------ACCNSDDVILCRTDAERG--------RHM 213

  Fly   534 VAIVLGACILCCIVLGVIVFRQRKCKAIASGMWTVLETILLGIVLLYASVAVHFFPASTERCLLE 598
            :......|.|.||.|..||..|||.:..|.| |.::|..|:|..:||:.:.:.|.......|.:.
 Worm   214 LLAFNSICALICIALIPIVCYQRKRQHEARG-WALMELFLIGASILYSVLFLDFVAPPEYGCCVA 277

  Fly   599 PWLRELGFITCYGAIILKLYRHLVDFRTRKAHRWVLRDVDLLKYLGTMVFAVICYMAAFTASS-- 661
            .|||::||...||:|:||:||:|.::|.|||....:|:.|:||||..|:...|..:.|:|..|
 Worm   278 VWLRQIGFSIFYGSIVLKIYRNLQEYRVRKAQHVSVREQDMLKYLAAMLALTITGLMAWTVGSWG 342

  Fly   662 -LDLLESAQLESLREADTNTCHPLKWELVTQTSEMLILCFGLHLSIASRNANTQFRERQFLVTAL 725
             ..|..:|..:.|.:.         |.::....|:|.|.:.:.|...:||::  :.||.....|:
 Worm   343 DTALWRTAWPQCLMQG---------WHVIWHGYELLFLLYAVRLCYKARNSD--WLERWQFTVAV 396

  Fly   726 TLEFLVSSSFYFLRFVYLPEMSPSAILLALFIRSQLTNSFALGLIFVPKLWYQHKQV--RSLAYD 788
            .||.:::.....:|:..........:.:..|:..|||.|..:.:|..||.:..:.:.  ||:.
 Worm   397 CLEAVITLMANLIRYSIRNSGRADTLFIVSFVHLQLTVSVNIVIIVAPKFYLSNGEPSRRSMT-- 459

  Fly   789 LSIRLPVDAFKGTSHDAGQRLGGGYAGLCLGDPDIGELTISEMSPEDIRAELKRLYTQLEIMKNK 853
                  :....|.:|.:..:|..   .:..|..|..|:.|::|:||||||||||:||||.:.|.|
 Worm   460 ------LGGHSGRAHPSLAKLRD---NILNGTIDFAEVPIADMNPEDIRAELKRVYTQLRMYKLK 515

  Fly   854 TLRQDNPHISKRRGGRKAGHRRFSLQKKGSKDKALSAKHRSNKHHQDIEITEAEP--SRTPED-- 914
            .|.||||||||:|||:|            ..||...|..|       |.|....|  .|..||
 Worm   516 NLYQDNPHISKKRGGKK------------WSDKNTKATRR-------ISIPSCSPQTKRIEEDEK 561

  Fly   915 -SVCSAEGPTDTY-AEISGVS-HSMLSHSMV 942
             .:.....|.:.| :...||: :|:..|:.|
 Worm   562 SDLTVESSPHNIYLSNFKGVNVNSIEQHNSV 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smog	NP_001245881.1	7tmC_GPR158-like	529..780	CDD:320420	73/253 (29%)
		TM helix 1	529..554	CDD:320420	8/24 (33%)
		TM helix 2	566..587	CDD:320420	6/20 (30%)
		TM helix 3	596..620	CDD:320420	11/23 (48%)
		TM helix 4	639..659	CDD:320420	7/19 (37%)
		TM helix 5	683..709	CDD:320420	5/25 (20%)
		TM helix 6	717..740	CDD:320420	5/22 (23%)
		TM helix 7	749..774	CDD:320420	6/24 (25%)
gpr-158	NP_493572.2	7tm_GPCRs	211..448	CDD:475119	73/248 (29%)
		TM helix 1	211..233	CDD:320420	7/21 (33%)
		TM helix 2	245..266	CDD:320420	6/20 (30%)
		TM helix 3	275..297	CDD:320420	10/21 (48%)
		TM helix 4	320..336	CDD:320420	5/15 (33%)
		TM helix 5	356..379	CDD:320420	5/31 (16%)
		TM helix 6	389..411	CDD:320420	4/21 (19%)
		TM helix 7	420..445	CDD:320420	6/24 (25%)