DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment smog and Gpr158

DIOPT Version :10

Sequence 1:NP_001245881.1 Gene:smog / 33690 FlyBaseID:FBgn0051660 Length:951 Species:Drosophila melanogaster
Sequence 2:NP_001163797.1 Gene:Gpr158 / 291352 RGDID:1305841 Length:1206 Species:Rattus norvegicus


Alignment Length:905 Identity:232/905 - (25%)
Similarity:361/905 - (39%) Gaps:189/905 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 YSLLVLLI---VGLATATAS--PS-------------------------PSPSHAPFGRESRRDA 162
            ||||:.|:   :||....||  ||                         |.|| .|:.| |....
  Rat     6 YSLLLCLLLAHLGLGEVGASLDPSERPDSSRERTSRGKQHGQQLPRASAPDPS-IPWSR-STDGT 68

  Fly   163 LLAYYKRAHLPQSSSSGISLGHKYHLLHDANGLDFDELTPTASSVSALSRAERFRLRKRSATPTT 227
            :||......:|...:|.:..| .:|.|..||               ...|.|...|..:|     
  Rat    69 ILAQKLAEEVPMDVASYLYTG-DFHQLKRAN---------------CSGRYELAGLPGKS----- 112

  Fly   228 PATAAGVTSLDVA-TAAAAATDAAAKDAGSGKKPEEKCEPK-------VLETLPDEPFYDYTDIA 284
            |:.|:...||..| .....||:.......|.|..|:..:..       |...|..||        
  Rat   113 PSLASSHPSLHGALDTLTHATNFLNMMLQSNKSREQTVQDDLQWYQALVRSLLEGEP-------- 169

  Fly   285 EDAARQFIEFLSGKFPNANTPIAIDEPTRAEVSRRANGIASYALNEDDNLLAFAIAAPSIHTVVV 349
             ..:|..|.|.:   .:.:||              |..:...|..|:..:|...:::.:.|..  
  Rat   170 -SISRAAITFST---ESLSTP--------------APQVFLQATREESRILLQDLSSSAHHLA-- 214

  Fly   350 KFRDNVTIPPDQVHNKAYLGSYWRE-------------LGAAWNSTDGT------QEWGAPFRDC 395
                |.|:..:..|.   |...||.             ||.:|...||.      .:|..||.:|
  Rat   215 ----NATLETEWFHG---LRRKWRPHLHRRGSNQGPRGLGHSWRRRDGLGGDRSHVKWSPPFLEC 272

  Fly   396 NLLTRR--WLWPFRISF--------SEHR-IKVVAAAFIAADEDVC-NDGLEEVFGRRHGCDRNT 448
            ...:.:  ||.....:|        .|.| :..|.......|.|.| :||.   |...|.|..|.
  Rat   273 ENGSYKPGWLVTLSAAFYGLQPNLVPEFRGVMKVDINLQKVDIDQCSSDGW---FSGTHKCHLNN 334

  Fly   449 TFCLLTENKPAATRDVYTCLCRESYYLP------NSTLQG----FRGDRVELSEGYDNYSCIPCP 503
            :.|:..:.. ......|.|:|:..:|.|      |...:|    |.|...::||  :.:.|:||.
  Rat   335 SECMPIKGL-GFVLGAYQCVCKAGFYHPRVFSVNNFQRRGPDHHFSGSTKDVSE--EAHVCLPCR 396

  Fly   504 GGCTNCDSNGVCLTFQEEEVLNVDACLRLLVAIVLGACILCCIVLGVIVFRQRKCKAI-ASGMWT 567
            .||..|..:..|  |.:|     |..|||.:......|:|...|..::|:..||.|:| |||: .
  Rat   397 EGCPFCADDRPC--FVQE-----DKYLRLAIISFQALCMLLDFVSMLVVYHFRKAKSIRASGL-I 453

  Fly   568 VLETILLGIVLLYASVAVHFFPASTERCLLEPWLRELGFITCYGAIILKLYRHLVDFRTRKAHRW 632
            :|||||.|.:|||..|.:.:|..||.||:|..|:|.|||.|.||.:.|||:|.|..|.:|.|.|.
  Rat   454 LLETILFGSLLLYFPVVILYFEPSTFRCILLRWVRLLGFATVYGTVTLKLHRVLKVFLSRTAQRI 518

  Fly   633 -VLRDVDLLKYLGTMVFAVICYMAAFTAS-----SLDLLESAQLESLREADTNTCHPLKWELVTQ 691
             .:....:::.|..:|..|..::..:|:|     ..|:|...|.::......|.|...:|:.:|.
  Rat   519 PYMTGGRVMRMLAVIVLVVFWFLVGWTSSMCQNLERDILLVGQGQTSDNLTFNMCLIDRWDYMTA 583

  Fly   692 TSEMLILCFGLHLSIASRNANTQFRERQFLVTALTLEFLVSSSFYFLRFVYLPEMSPSAILLALF 756
            .:|.|.|.:|::|..|.|...:.|.|.:::..|:..|.::::.|:.:|||....:.|..:|:..|
  Rat   584 VAEFLFLLWGIYLCYAVRTVPSAFHEPRYMAVAVHNELIITAIFHTIRFVLASRLQPDWMLMLYF 648

  Fly   757 IRSQLTNSFALGLIFVPKLWYQHKQVRSLAYDLSIRLPVDAFKGTSHDAGQRLGGGYAGLCLGDP 821
            ..:.||.:..:||:.:||..:.....|.   |::    .:|::       ..|..|.:|..|...
  Rat   649 AHTHLTVTVTIGLLLIPKFSHSSNNPRD---DIA----TEAYE-------DELDMGRSGSYLNSS 699

  Fly   822 DIGELTISEMSPEDIRAELKRLYTQLEIMKNKTLRQDNPHISKRRGGRKAGHRRF---------S 877
            .....:...:.|||||.|||:||.||||.|.|.:..:|||:.|:|..:|...|..         :
  Rat   700 INSAWSEHSLDPEDIRDELKKLYAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPET 764

  Fly   878 LQKKGSKDKALSAKHRSNKHHQDIEITEAEPS----RTPEDS----VCSAEGPTDTYAEI 929
            :.::.||:......|.:.|....:.....|.|    |..|:|    |.|.:....||..:
  Rat   765 VSRQCSKEDKEGTDHSAAKGTGLVRKNPTESSGNTGRPKEESLKNRVFSLKKSHSTYDHV 824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
smogNP_001245881.1 7tmC_GPR158-like 529..780 CDD:320420 83/257 (32%)
TM helix 1 529..554 CDD:320420 7/24 (29%)
TM helix 2 566..587 CDD:320420 10/20 (50%)
TM helix 3 596..620 CDD:320420 12/23 (52%)
TM helix 4 639..659 CDD:320420 3/19 (16%)
TM helix 5 683..709 CDD:320420 8/25 (32%)
TM helix 6 717..740 CDD:320420 4/22 (18%)
TM helix 7 749..774 CDD:320420 6/24 (25%)
Gpr158NP_001163797.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 25..62 7/37 (19%)
Cache-like region. /evidence=ECO:0000250|UniProtKB:Q5T848 85..281 48/251 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 234..253 3/18 (17%)
7tmC_GPR158-like 415..672 CDD:320420 83/257 (32%)
TM helix 1 415..440 CDD:320420 7/24 (29%)
TM helix 2 452..473 CDD:320420 10/21 (48%)
TM helix 3 482..506 CDD:320420 12/23 (52%)
TM helix 4 526..546 CDD:320420 3/19 (16%)
TM helix 5 575..601 CDD:320420 8/25 (32%)
TM helix 6 609..632 CDD:320420 4/22 (18%)
TM helix 7 641..666 CDD:320420 6/24 (25%)
DUF612 704..>1056 CDD:282585 36/121 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..899 13/68 (19%)
VCPWE motif 1. /evidence=ECO:0000250|UniProtKB:Q5T848 1006..1010
VCPWE motif 2. /evidence=ECO:0000250|UniProtKB:Q5T848 1071..1075
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1136..1166
VCPWE motif 3. /evidence=ECO:0000250|UniProtKB:Q5T848 1171..1175
Blue background indicates that the domain is not in the aligned region.

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